Results 51 to 60 of about 21,610 (241)

Affinity‐Based Interactome Mapping of Inositol Pyrophosphates Reveals 4/6‐PP‐InsP5‐Binding Proteins in Plants

Advanced Science, EarlyView.
ABSTRACT Inositol pyrophosphates (PP‐InsPs) are central regulators of eukaryotic signaling events. While certain PP‐InsP isomers have been conclusively linked to the regulation of phosphate homeostasis through interaction with SPX domain‐containing proteins in plants, the functions of the recently discovered isomer 4/6‐PP‐InsP5 remain largely unknown ...
Kevin Ritter, Verena Gaugler, Sara Christina Stolze, Riya Ghosh, Akhila Jayamon, Ranjana Yadav, Felix Wollensack, Debabrata Laha, Hirofumi Nakagami, Gabriel Schaaf, Henning Jacob Jessen   +10 more
wiley   +1 more source

Enhanced N-Glycan Profiling of Therapeutic Monoclonal Antibodies through the Application of Upper-Hinge Middle-Up Level LC-HRMS Analysis

Antibodies
Therapeutic monoclonal antibodies (mAbs) are crucial in modern medicine due to their effectiveness in treating various diseases. However, the structural complexity of mAbs, particularly their glycosylation patterns, presents challenges for quality ...
Natalia Mesonzhnik, Anton Belushenko, Polina Novikova, Alexey Kukharenko, Mikhail Afonin   +4 more
doaj   +1 more source

A Transversal Approach Combining In Silico, In Vitro and In Vivo Models to Describe the Metabolism of the Receptor Interacting Protein 1 Kinase Inhibitor Sibiriline

Pharmaceutics, 2022
Sibiriline is a novel drug inhibiting receptor-interacting protein 1 kinase (RIPK1) and necroptosis, a regulated form of cell death involved in several disease models.
Romain Pelletier, Thomas Gicquel, Mélanie Simoes Eugenio, Pierre-Jean Ferron, Isabelle Morel, Claire Delehouzé, Marie-Thérèse Dimanche-Boitrel, Morgane Rousselot, Brendan Le Daré   +8 more
doaj   +1 more source

Highly reliable LC-MS lipidomics database for efficient human plasma profiling based on NIST SRM 19501

Journal of Lipid Research
Liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS)-based methods have become the gold standard methodology for the comprehensive profiling of the human plasma lipidome. However, both the complexity of lipid chemistry and LC-HRMS-
Sara Martínez, Miguel Fernández-García, Sara Londoño-Osorio, Coral Barbas, Ana Gradillas   +4 more
doaj   +1 more source

Characterization of Ten Novel Metabolites of a PAF Antagonist SY0916 in Rats Using LC-MS and NMR

Metabolites
Background: SY0916 is a novel PAF receptor antagonist used to treat chronic immune-inflammatory diseases and is currently undergoing phase II clinical trials.
Xin He, Tingting Zhang, Hongyi Zhao, Chen Ma   +3 more
doaj   +1 more source

Novel nontarget LC-HRMS-based approaches for evaluation of drinking water treatment

Environmental Monitoring and Assessment, 2023
AbstractA conventional evaluation methodology for drinking water pollution focuses on analysing hundreds of compounds, usually by liquid chromatography–tandem mass spectrometry. High-resolution mass spectrometry allows comprehensive evaluation of all detected signals (compounds) based on their elemental composition, intensity, and numbers.
Nováková, Petra, Švecová, Helena, Bořík, Adam, Grabic, Roman   +3 more
openaire   +2 more sources

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Profiling of Organosulfur Compounds in Onions: A Comparative Study between LC-HRMS and DTD-GC-MS

Chemosensors
Onions are known not only for their culinary importance but also for their nutritional and health-promoting properties. Both properties are closely linked to their content of organosulfur compounds, which account for up to 5% of the dry weight of an ...
Ana V. González-de-Peredo, Alicia Maroto, Gerardo F. Barbero, Antony Memboeuf   +3 more
doaj   +1 more source

Clinician's attitudes & perspective on chemical adherence testing in hypertension (CATCH): A qualitative interview study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Chemical Adherence Testing (CAT) is gaining prominence as a reliable and valid clinical method to detect whether antihypertensive agents are being taken as prescribed. This study aimed to explore clinicians' attitudes and perspectives on the clinical use of CAT.
Roshan Shahab, Louise Rabbitt, Gerard J. Molloy   +2 more
wiley   +1 more source

Implementation of a community-based LC-UV drug checking service: promising preliminary findings on feasibility and validity

Harm Reduction Journal
Background The increasing diversity of psychoactive substances on the unregulated drug market poses significant health, psychological, and social risks to people who use drugs (PWUD). To address these risks, various harm reduction (HR) policies have been
Nicolas Fabresse, Eurydice Papias, Alma Heckenroth, Victor Martin, Daniel Allemann, Perrine Roux   +5 more
doaj   +1 more source