Results 71 to 80 of about 255,317 (292)

Exploring the Occurrence of Organic Contaminants in Human Semen through an Innovative LC-HRMS-Based Methodology Suitable for Target and Nontarget Analysis

, 2023
Understanding the potential impact of organic contaminants on male fertility is crucial, yet limited studies have examined these chemicals in semen, with most focusing on urine and blood.
Elena Sánchez-Resino (17350323), Montse Marquès (17350326), Rubén Gil-Solsona (17350338), Nancy Babio (311717), Pablo Gago-Ferrero (1506517), Daniel Gutiérrez-Martín (17350329), Albert Salas-Huetos (7863254), Esteban Restrepo-Montes (17350332), María Ángeles Martínez (17350335), Jordi Salas-Salvadó (1696228)   +9 more
core   +1 more source

Non-target LC-HRMS to Study the Exposome of Mild Cognitive Impairment and Alzheimer’s Disease on Cerebrospinal Fluid [PDF]

, 2023
Alzheimer’s Disease (AD) is a complex and multifactorial neurodegenerative disease. The current diagnosis relies on non-specific biomarkers (Aβ1-42, t-Tau, and p-Tau) measured in cerebrospinal fluid (CSF), which do not provide sufficient insights into ...
Cheng, Tiejun, MARY, Arnaud, HENEKA, Michael, SCHYMANSKI, Emma, Bolton, Evan, TALAVERA ANDUJAR, Begona, Zaslavsky, Leonid   +6 more
core   +1 more source

Tandem Duplication‐Driven Neofunctionalization of UDP‐Glycosyltransferases Shapes the Diversification of Triterpenoid Saponins in the Cucurbitaceae

Advanced Science, EarlyView.
We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.
Guangyi Wang, Mengmeng Li, Xuehui Dai, Yanchen Zhang, Yuhan Wu, Zhaotao Yan, Chenfei Tian, Hongkai Fan, Haili Liu, Xiaowei Zhang, Yiming Yang, Jiayu Lu, Yuwei Sun, Yong Wang   +13 more
wiley   +1 more source

Enhanced N-Glycan Profiling of Therapeutic Monoclonal Antibodies through the Application of Upper-Hinge Middle-Up Level LC-HRMS Analysis

Antibodies
Therapeutic monoclonal antibodies (mAbs) are crucial in modern medicine due to their effectiveness in treating various diseases. However, the structural complexity of mAbs, particularly their glycosylation patterns, presents challenges for quality ...
Natalia Mesonzhnik, Anton Belushenko, Polina Novikova, Alexey Kukharenko, Mikhail Afonin   +4 more
doaj   +1 more source

Mechanistic investigation of Liujing Toutong tablet in the treatment of cerebral ischemia–reperfusion injury in rats by the integration of serum pharmacochemistry and metabolomics

Animal Models and Experimental Medicine, EarlyView.
The research strategy for pharmacodynamics, serum pharmacochemistry, metabolomics, and network pharmacology analysis method in intervention effects of LTT are illustrated. Abstract Background Liujing Toutong tablet (LTT) is a traditional Chinese patent medicine.
Zihan Yu, Ke Pei, Xiulin Wang, Wenling Li, Hongchang Li, Wangyang Xie, Xianglong Meng, Tingting Zhao, Yan Ning, Haixin Liu, Wenbin He   +10 more
wiley   +1 more source

Phytochemical screening of Calotropis gigantea by LC- HRMS

Calotropis gigantea commonly known as ‘Shweta Arka’ is a highly medicinal drought resistant. Plant contains milky latex in the stem which is used as an antidote for snake poison in dried form. Whereas, dried leaves of the Calotropis plant are used as an expectorant and anti- inflammatory for the cure of paralysis and rheumatic pains.
Swati Tanaji Lawand, Vaishali Sangram Shewale   +1 more
openaire   +2 more sources

LC-HRMS/MS spectra of the DON biotransformation products.

, 2015
a) DON-malonylglucoside, b) 15-acetyl-DON-3-β-D-glucoside and c) “DON-2H”-S glutathione (GSH), all LC-HRMS/MS spectra are shown with a proposed structure formula.
Imer Maloku (702454), Rudolf Krska (702455), Alexandra Malachova (702452), Marc Lemmens (702450), Herbert Michlmayr (702451), Andrea Koutnik (702453), Franz Berthiller (645066), Christoph Bueschl (702449), Gerhard Adam (645067), Rainer Schuhmacher (702456), Bernhard Kluger (702448)   +10 more
core   +1 more source

Additional file 1 of Symphytum ibericum Steven: LC–HRMS/MS-based phytochemical profile, in vitro antioxidant and enzyme inhibitory potential

, 2022
Additional file 1: Figure S1. LC–HRMS/MS chromatograms (base peak chromatograms) of Symphytum ibericum LEAF extracts. Figure S2. LC–HRMS/MS chromatograms (base peak chromatograms) of Symphytum ibericum ROOT extracts. Figure S3.
Adriana Trifan (578311), Kouadio Ibrahime Sinan (9284295), Krystyna Skalicka-Woźniak (625326), Gokhan Zengin (663484), Simon Vlad Luca (12968070), Mirjana Minceva (2571724)   +5 more
core   +1 more source

Highly reliable LC-MS lipidomics database for efficient human plasma profiling based on NIST SRM 19501

Journal of Lipid Research
Liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS)-based methods have become the gold standard methodology for the comprehensive profiling of the human plasma lipidome. However, both the complexity of lipid chemistry and LC-HRMS-
Sara Martínez, Miguel Fernández-García, Sara Londoño-Osorio, Coral Barbas, Ana Gradillas   +4 more
doaj   +1 more source

Quantification Approaches in Non-Target LC/ESI/HRMS Analysis:An Interlaboratory Comparison [PDF]

Nontargeted screening (NTS) utilizing liquid chromatography electrospray ionization high-resolution mass spectrometry (LC/ESI/HRMS) is increasingly used to identify environmental contaminants.
Malm, Louise, Chrastina, David, Luckute, Austeja, Caupos, Emilie, van der Neut-Marchand, Carla, Roscioli, Claudio, Valdecanas, Belinda, Abis, Pier Paolo, Arturi, Katarzyna, Frigerio, Gianfranco, Fildier, Aurélie, Joerss, Hanna, Peruzzo, Massimo, Garcia-Vara, Manuel, Soulier, Coralie, Christensen, Jan, H, Rostkowski, Pawel, Davis, W. Clay, Mazzetti, Michele, Coppola, Gianluca, Thomaidis, Nikolaos, S, Kochmann, Sven, Aalizadeh, Reza, Wiest, Laure, Thomaidis, Nikolaos S., Verwoert, Milan, Steininger-Mairinger, Teresa, Haelewyck, Niels, Pieke, Eelco, N, SCHYMANSKI, Emma, Plassmann, Merle, Vulliet, Emmanuelle, Nanusha, Mulatu Yohannes, Mebold, Emmanuelle, Christensen, Jan H., Pijnappels, Martijn, Nanusha, Mulatu, Yohannes, Fro̷kjær, Emil Egede, Tisler, Selina, Hollender, Juliane, Talavera Andújar, Begoña, Kunkel, Uwe, Hansen, Martin, Le Roux, Julien, Esperanza, Mar, Kruve, Anneli, Pieke, Eelco N., Davis, W Clay, Fro̷kjær, Emil, Egede, Kumari, Sangeeta, Covaci, Adrian, Letzel, Thomas, Bieber, Stefan, Balest, Lydia, Belova, Lidia, López de Alda, Miren, Gundersen, Hans, Macan Schönleben, Alicia, Helmus, Rick, Murgolo, Sapia, Celma, Alberto, Bijlsma, Lubertus, Davis, W, Clay, Alygizakis, Nikiforos, Schymanski, Emma, L, Valsecchi, Sara, Liigand, Jaanus, Kaserzon, Sarit, Gago-Ferrero, Pablo, Fro Kjær, Emil Egede, Kasprzyk-Hordern, Barbara, Troia, Eugenie, Licul-Kucera, Viktória, Ng, Kelsey, Gil-Solsona, Ruben, Leroy, Gaëla, Vughs, Dennis, Bader, Tobias, Aurich, Dagny, Macherius, André, Pieke, Eelco N, Meekel, Nienke, de Rijke, Eva, Thomaidis, Nikolaos S, Mascolo, Giuseppe, Schulze, Bastian, Abis, Pier, Paolo, Ceolotto, Nicola, Hann, Stephan, Christensen, Jan H, Schymanski, Emma L, Schymanski, Emma L.   +91 more
core   +1 more source