Results 71 to 80 of about 330,504 (280)

Semiquantitation of Paralytic Shellfish Toxins by Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry Using Relative Molar Response Factors

Toxins, 2020
Paralytic shellfish toxins (PSTs) are a complex class of analogs of the potent neurotoxin saxitoxin (STX). Since calibration standards are not available for many PSTs, including C-11 hydroxyl analogs called M-toxins, accurate quantitation by liquid ...
Jiangbing Qiu, Elliott J. Wright, Krista Thomas, Aifeng Li, Pearse McCarron, Daniel G. Beach   +5 more
doaj   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Structure and Biosynthesis of Mangotoxin Produced by the Plant Pathogen Pseudomonas syringae

Angewandte Chemie, EarlyView.
The structure of mangotoxin remained elusive for over two decades. Here, mangotoxin was isolated from the native producer, Pseudomonas syringae pv. syringae, and was determined to be an alkyne‐containing dipeptide. Mangotoxin inhibited the growth of multidrug‐resistant human pathogen Klebsiella pneumoniae.
Alexis H. Murray, Sohan Hazra, Ryan W. Mull, Erinn M. O'Neill, Bo Li   +4 more
wiley   +2 more sources

Enhanced N-Glycan Profiling of Therapeutic Monoclonal Antibodies through the Application of Upper-Hinge Middle-Up Level LC-HRMS Analysis

Antibodies
Therapeutic monoclonal antibodies (mAbs) are crucial in modern medicine due to their effectiveness in treating various diseases. However, the structural complexity of mAbs, particularly their glycosylation patterns, presents challenges for quality ...
Natalia Mesonzhnik, Anton Belushenko, Polina Novikova, Alexey Kukharenko, Mikhail Afonin   +4 more
doaj   +1 more source

Untargeted Metabolomic Approach to Study the Impact of Aging on Salivary Metabolome in Women

Metabolites, 2022
Despite the growing interest in salivary metabolomics, few studies have investigated the impact of aging on the salivary metabolome. The alterations in metabolic pathways that occur with aging are likely to be observed in pathologies affecting older ...
Pauline Bosman, Valérie Pichon, Ana Carolina Acevedo, Laëtitia Le Pottier, Jacques Olivier Pers, Hélène Chardin, Audrey Combès   +6 more
doaj   +1 more source

Covalently Integrated Selenoviologen–N‐Heterocyclic Carbene–Pt Nanoparticles for Visible‐Light‐Driven Hydrogen Evolution

Advanced Science, EarlyView.
A covalently integrated single‐component photocatalyst is constructed by anchoring selenoviologen to platinum nanoparticles via robust N‐heterocyclic carbene ligands. The resulting Pt─C covalent bonds function dually as protective structural scaffolds and direct channels for ultrafast intramolecular electron transfer This precise interfacial ...
Wenxi He, Guoping Li, Chenjing Liu, Yu Liu, Yawen Li, Wenxin Wei, Hairui Lei, Ni Yan, Gang He   +8 more
wiley   +1 more source

Detection and Excretion Profile of Retatrutide in Human Plasma and Urine by LC-HRMS: Implications for Antidoping Analysis. [PDF]

Rapid Commun Mass Spectrom
ABSTRACT Rationale Retatrutide (LY3437943) is a novel long‐acting triple incretin receptor agonist that targets the glucagon‐like peptide‐1 receptor (GLP‐1R), glucose‐dependent insulinotropic polypeptide receptor (GIPR), and glucagon receptor (GCGR). Its pronounced effects on body composition and metabolic health, combined with increasing off‐label use
Carneiro GRA, da Costa Nunes IK, Dos Santos Cardoso GR, Dos Santos PF, Padilha MC, Nogueira FCS, Pereira HMG.   +6 more
europepmc   +2 more sources

A C‐Nucleoside Analogue of Cordycepin With High Metabolic Stability and Potent Anti‐Psoriatic Activity via Microneedle Delivery

Advanced Science, EarlyView.
This work identified CPD3a as a potent, stable C‐nucleoside cordycepin derivative. When formulated into microneedle array for topical treatment, it ameliorated psoriasis by rebalancing immunity and enhancing antioxidant defenses. ABSTRACT Psoriasis is a chronic inflammatory disorder characterized by immune dysregulation and epidermal hyperplasia ...
Wenfang Pan, Xinyue Shao, Yuanchen Zhong, Xujie Sun, Lixuan Yin, Zongyan He, Tianqun Lang, Yuanchao Xie   +7 more
wiley   +1 more source

Phytochemical screening of Calotropis gigantea by LC- HRMS

Calotropis gigantea commonly known as ‘Shweta Arka’ is a highly medicinal drought resistant. Plant contains milky latex in the stem which is used as an antidote for snake poison in dried form. Whereas, dried leaves of the Calotropis plant are used as an expectorant and anti- inflammatory for the cure of paralysis and rheumatic pains.
Swati Tanaji Lawand, Vaishali Sangram Shewale   +1 more
openaire   +2 more sources

Prioritization of Unknown LC-HRMS Features Based on Predicted Toxicity Categories

Environmental Science & Technology
Complex environmental samples contain a diverse array of known and unknown constituents. While liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS) nontargeted analysis (NTA) has emerged as an essential tool for the comprehensive study of such samples, the identification of individual constituents remains a significant ...
Viktoriia Turkina, Jelle T. Gringhuis, Sanne Boot, Annemieke Petrignani, Garry Corthals, Antonia Praetorius, Jake W. O’Brien, Saer Samanipour   +7 more
openaire   +4 more sources