Results 61 to 70 of about 255,317 (292)

Characterization of Phase I and Glucuronide Phase II Metabolites of 17 Mycotoxins Using Liquid Chromatography—High-Resolution Mass Spectrometry

Toxins, 2019
Routine mycotoxin biomonitoring methods do not include many mycotoxin phase I and phase II metabolites, which may significantly underestimate mycotoxin exposure especially for heavily metabolized mycotoxins. Additional research efforts are also needed to
Irina Slobodchikova, Reajean Sivakumar, Md Samiur Rahman, Dajana Vuckovic   +3 more
doaj   +1 more source

Overcoming challenges in untargeted LC-HRMS-based metabolomics approaches

, 2021
Die Flüssigkeitschromatografie – Hochauflösungs-Massenspektrometrie (LC-HRMS) wird in Metabolomstudien für den ungerichteten Nachweis einer möglichst großen Metabolitzahl in biologischen Proben eingesetzt.
Ceranic, Asja
core  

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source

Identification and Initial Testing of Anticancer Compounds from Marine Sponge Extract Clathria sp. From Padamarang Island, Kolaka Regency [PDF]

BIO Web of Conferences
A study has been conducted on the identification and initial testing of anticancer compounds from the sponge extract of Clathria sp. from the waters of Padamarang Island, Kolaka Regency. This study aims to identify compounds and conduct toxicity tests of
Zahwa Kirana Danya, Syam Ainul Mardiah, Hasmidar, Ramadhan Muhammad Fajri, Arami Hasnia, Sari Rina Sardiana   +5 more
doaj   +1 more source

LC-HRMS-Database Screening Metrics for Rapid Prioritization of Samples to Accelerate the Discovery of Structurally New Natural Products [PDF]

, 2019
In order to accelerate the isolation and characterization of structurally new or novel secondary metabolites, it is crucial to develop efficient strategies that prioritize samples with greatest promise early in the workflow so that resources can be ...
Daniel Butler (6316787), Alan James Smith (6316778), Feussner, Klaus, Hai Deng (1508176), Pellissier, Léonie, Hardy, David, Butler, Daniel, Montesanto, Federica, Edward J. Milton (6316790), David Hardy (848279), Milne, Bruce F., Ebel, Rainer, Rainer Ebel (1508158), Subko, Karolina, Deng, Hai, Carmela Gissi (55058), Marika Salonna (6316793), Kidd, Richard, Richard Kidd (393807), Milne, Bruce F, Tabudravu, Jioji N., Jioji N. Tabudravu (2206303), Sharon M. Kelly (132485), Karolina Subko (6316781), Léonie Pellissier (6239507), Caroline Autréau (6316784), Klaus Feussner (2352517), Salonna, Marika, Autréau, Caroline, Bruce F. Milne (1273305), Cimpan, Gabriela, Kelly, Sharon M, Gissi, Carmela, Tabudravu, Jioji, Smith, Alan James, Marcel Jaspars (14663), Milton, Edward J., Gabriela Cimpan (3963821), Milton, Edward J, Federica Montesanto (6316796), Jaspars, Marcel, Kelly, Sharon M.   +41 more
core   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Major metabolites detected in Yucca aloifolia fruits via nano LC-HRMS/MS.

, 2023
Major metabolites detected in Yucca aloifolia fruits via nano LC-HRMS/MS.
Esraa S. Habiba (14691631), Dalia E. Ali (14691625), Eman M. Omar (14691637), Shaymaa A. Abdulmalek (4025555), Eman A. Allam (14691634), Samar M. Bassam (14691628), Soha Elatrebi (12345537), Essam Abdel-Sattar (624345), Doaa A. Ghareeb (9267671)   +8 more
core   +1 more source

Efficient Concentration and Complete Destruction of Short‐Chain and Emerging PFAS in Contaminated Water via Integrated Interface Engineering‐Enhanced Carbon Felt Sorption and Photochemical Processes

Advanced Science, EarlyView.
A closed‐loop “Concentrate‐Destroy” strategy is presented for completely eliminating short‐chain and emerging PFAS, in which the new 3D PPy@P‐CF is used for efficiently concentrating PFAS and Cu2+‐mediated photodegradation is applied for the completely destroying PFAS in the sorbent regeneration eluent.
Hao Yu, Jialei Guo, Peng Zhang, Hongyi Li, Feng He, Hongwen Sun   +5 more
wiley   +1 more source

Semiquantitation of Paralytic Shellfish Toxins by Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry Using Relative Molar Response Factors

Toxins, 2020
Paralytic shellfish toxins (PSTs) are a complex class of analogs of the potent neurotoxin saxitoxin (STX). Since calibration standards are not available for many PSTs, including C-11 hydroxyl analogs called M-toxins, accurate quantitation by liquid ...
Jiangbing Qiu, Elliott J. Wright, Krista Thomas, Aifeng Li, Pearse McCarron, Daniel G. Beach   +5 more
doaj   +1 more source

Untargeted Metabolomic Approach to Study the Impact of Aging on Salivary Metabolome in Women

Metabolites, 2022
Despite the growing interest in salivary metabolomics, few studies have investigated the impact of aging on the salivary metabolome. The alterations in metabolic pathways that occur with aging are likely to be observed in pathologies affecting older ...
Pauline Bosman, Valérie Pichon, Ana Carolina Acevedo, Laëtitia Le Pottier, Jacques Olivier Pers, Hélène Chardin, Audrey Combès   +6 more
doaj   +1 more source