Results 71 to 80 of about 21,610 (241)

LC–HRMS determination of piperine on rat dried blood spots: A pharmacokinetic study

Journal of Pharmaceutical Analysis, 2016
A liquid chromatography–high resolution mass spectrometry (LC–HRMS) method was developed and validated for the determination of piperine (PPR) on dried blood spots (DBS).
Bokka Ramesh, P. Rajesh Rao Vadaparthi, Genji Sukumar, Nemali Manjula, Katragadda Suresh Babu, Potturi Sita Devi   +5 more
doaj   +1 more source

Bioactivation and Metabolism of Amino Acid MDMA Prodrugs in Zebrafish Embryos, Human Liver S9, Whole Blood, and Microdosed Human Urine

Drug Testing and Analysis, EarlyView.
Bioactivation and metabolism of MDMA prodrugs: MDMA‐Trp, MDMA‐Lys, MDMA‐Gly showed unique urine screening targets only for MDMA‐Trp, while biomarkers for MDMA‐Lys and MDMA‐Gly consisted of MDMA and known MDMA metabolites. Conversion of amino acid prodrugs to MDMA in pHLS9, zebrafish embryos, and humans. ABSTRACT 3,4‐Methylenedioxymethamphetamine (MDMA)
Simon K. Wellenberg, Lea Wagmann, Matthias D. Kroesen, Philip Schippers, Matthias Grill, Jennifer Herrmann, Markus R. Meyer   +6 more
wiley   +1 more source

Evaluation of Different Detection and Identification Methods of Intact Tetrahydro‐Methyltestosterone Sulfate Metabolites in Doping Control

Drug Testing and Analysis, EarlyView.
The micro‐scale synthesis of the six out of eight possible tetrahydro‐methyltestosterone sulfate metabolites was performed, and the synthesized materials were used as analytical standards. The analysis of post‐administration sample extracts from methyltestosterone excretion studies against these standards provides further experimental proof for their ...
Yiannis S. Angelis, Olga Goula, Polyxeni Kiousi, Panagiotis Sakellariou   +3 more
wiley   +1 more source

A Sensitive LC-MS/MS Method for Palytoxin Using Lithium Cationization

Toxins, 2018
Palytoxin (PlTX) and analogues are produced by certain dinoflagellates, sea anemones, corals and cyanobacteria. PlTX can accumulate in the food chain and when consumed it may cause intoxication with symptoms like myalgia, weakness, fever, nausea, and ...
Mirjam D. Klijnstra, Arjen Gerssen
doaj   +1 more source

High atmospheric pressure rescues plant growth under humidity stress: A model for climate‐resilient deep underground agriculture

Deep Underground Science and Engineering, EarlyView.
High atmospheric pressure (120 kPa) in deep underground counteracts humidity‐induced physiological stress in plants, stabilizing water balance and enhancing antioxidative defenses. This synergy boosts biomass despite elevated humidity, demonstrating sustainable deep underground agriculture potential under climate uncertainty.
Yuxin He, Linglu Xu, Xiao Tan, Wenhua Zhuang, Naiwen Li, Chao Liu, Bo Tan   +6 more
wiley   +1 more source

Targeted Isolation of Prenylated Flavonoids from Paulownia tomentosa Fruit Extracts via AI-Guided Workflow Integrating LC-UV-HRMS/MS

Metabolites
Objectives: This study presents a versatile, AI-guided workflow for the targeted isolation and characterization of prenylated flavonoids from Paulownia tomentosa (Thunb.) Steud. (Paulowniaceae). Methods: The approach integrates established extraction and
Tomas Rypar, Lenka Molcanova, Barbora Valkova, Ema Hromadkova, Christoph Bueschl, Bernhard Seidl, Karel Smejkal, Rainer Schuhmacher   +7 more
doaj   +1 more source

Synergistic Photo‐Electro‐Fenton Oxidation of Antibiotics Using a Ferrocene‐Functionalized MXene (Ti3C2Tx) Electrode

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
2D MXene (Ti3C2Tx)‐based electrode setup for hybrid photo‐electro‐Fenton degradation of antibiotic (tetracycline). The persistence of antibiotics such as tetracycline in aquatic systems poses severe environmental and health risks by potential antimicrobial resistance.
Durga Sankar Vavilapalli, Gordian Sandberg, Leiqiang Qin, Joseph Halim, Andrejs Petruhins, Daniel Dahlberg, Markus Axelsson, Anneli Kruve, Johanna Rosen   +8 more
wiley   +1 more source

Exploring the Behaviour of Emerging Contaminants in the Water Cycle using the Capabilities of High Resolution Mass Spectrometry

CHIMIA, 2014
To characterize a broad range of organic contaminants and their transformation products (TPs) as well as their loads, input pathways and fate in the water cycle, the Department of Environmental Chemistry (Uchem) at Eawag applies and develops ...
Juliane Hollender, Marc Bourgin, Kathrin B. Fenner, Philipp Longrée, Christa S. Mcardell, Christoph Moschet, Matthias Ruff, Emma L. Schymanski, Heinz P. Singer   +8 more
doaj   +1 more source

Covalent Immobilization of Laccase on Mesoporous Bismuth Silicate for High‐Performance Biodegradation of Contaminants

European Journal of Inorganic Chemistry, EarlyView.
Myceliophthora thermophila laccase covalently immobilized on bismuth silicate (BiSi‐ext) achieved synergistic adsorption–biodegradation of Tectilon Blue 4R‐01 and ibuprofen. The biocatalyst showed enhanced stability, reusability, and rapid pollutant removal via expanded active‐site accessibility, enabling efficient, eco‐friendly wastewater remediation.
Erick Paiva Cancella, Guilherme de Paula Guarnieri, Yuriy B. Lipisa, Fábio Rogério de Moraes, Adriano de Vasconcellos, Giselle Maria Maciel, José Geraldo Nery   +6 more
wiley   +1 more source

Additives Promote Divergent Reactivity in Photolytic Deoxygenation and Lactonization Reactions of Cobalt Alkoxycarbonyls

European Journal of Organic Chemistry, EarlyView.
We report a carbonylation‐homolysis process to access acyl radicals that can undergo decarboxylation or cyclization onto tethered alkenes. In both cases, ligands and additives are shown to influence the outcome to give saturated or unsaturated products, in some cases with isomerization of the initial products.
Jacob N. Hackbarth, Dana R. Chambers, Cory T. Ludwig, Tyler K. Brown, David B. C. Martin   +4 more
wiley   +1 more source