Results 141 to 150 of about 4,803 (181)

Estimating Short-Term LC50 Values

Fire Technology, 1976
The authors discuss correlations of LC50 data and suggest that one possible use of them may be in the design of toxicity test procedures.
Carlos J. Hilado, Arthur Furst
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Correlation between LC50 for Adult Fish and Fish Embryos

Bulletin of Experimental Biology and Medicine, 2017
Testing for substance toxicity for living organisms is an important step in the development and adaptation of new drugs for various purposes. Analysis of the dependences between toxicological parameters of chemical substances for various test objects and physicochemical properties of these agents is a promising trend. Partition coefficient logP (logKow)
K V, Zolotarev, K V, Nakhod, A N, Mikhailov, M V, Mikhailova   +3 more
openaire   +2 more sources

A QSAR model for predicting toxicity (LC50) to rainbow trout

Water Research, 2002
A fragment constant method for prediction of toxicity (LC50) to rainbow trout was developed based on the experimental LC50 values of 258 chemicals obtained from the literature. The dataset was randomly divided into a training set and a validation set for purposes of model development and validation.
S, Tao, Xiaohuan, Xi, Fuliu, Xu, Richard, Dawson   +3 more
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Determination of LC50 and sub-chronic neurotoxicity of diesel exhaust nanoparticles

Environmental Toxicology and Pharmacology, 2015
Air pollution is a major problem faced globally and is seen associated with central nervous system (CNS) disorders like neuropathology and neuro-inflammation. Here, we investigated the CNS disorders as a result of sub-chronic exposure (90 days) to diesel exhaust nanoparticles (DENPs) and explored the minimal levels of DENPs needed to exhibit the early ...
M, Durga, T, Devasena, A, Rajasekar
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Estimators for the LC50

1988
Dit rapport geeft een kritisch overzicht van statistische methoden voor het schatten van de LC50. Met name wordt aandacht besteed aan de bruikbaarheid van deze methoden bij het type gegevens dat bij toxiciteitstoetsen vaak voorkomt.
Hoekstra, JA
openaire   +3 more sources

Chlorosilane Acute Inhalation Toxicity and Development of an LC50 Prediction Model

Inhalation Toxicology, 2006
The acute inhalation toxicity of 10 chlorosilanes was investigated in Fischer 344 rats using a 1-h whole-body vapor inhalation exposure and a 14-day recovery period. The median lethal concentration (LC50(1)) for each material was calculated from the nominal exposure concentrations and mortality.
Paul A, Jean, Robert H, Gallavan, Gary B, Kolesar, Waheed H, Siddiqui, Jon A, Oxley, Robert G, Meeks   +5 more
openaire   +2 more sources

Methods for Calculating an LC50

1977
A variety of graphical and computational methods can be used to derive a median lethal concentration (LC50) from concentration-mortality data produced by an acute mortality test. In the selection of a method, practical considerations should receive as much attention as the usual theoretical and statistical considerations.
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Measuring cytotoxicity: a new perspective on LC50.

Anticancer research, 2007
Cytotoxicity in cell culture is typically expressed as LC50 the concentration of a given agent which is lethal to 50% of the cells. This number is dependent on the incubation time with the agent. Previously, a two-term exponential model has been proposed to describe cell growth after a cytotoxic event: y(t) = k, * exp(-d(1)*t) + k2 * exp(d(2)*t).
Ming, Zhang, Dolly, Aguilera, Chandra, Das, Hernan, Vasquez, Peter, Zage, Vidya, Gopalakrishnan, Johannes, Wolff   +6 more
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Dependence between LD50 for Rodents and LC50 for Adult Fish and Fish Embryos

Bulletin of Experimental Biology and Medicine, 2017
We revealed empirical dependences between common logarithm of a ratio of rat oral LD50 to LCa50 for adult fish and lgP for 50 different chemicals; and common logarithm of a ratio of the oral LD50 in rodents to LCe50 for fish embryos and lgP for 30 different chemicals.
K V, Zolotarev, N F, Belyaeva, A N, Mikhailov, M V, Mikhailova   +3 more
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The utility of computed superdelocalizability for predicting the LC50 values of epoxides to guppies

Science of The Total Environment, 1991
A quantitative structure-activity relationship (QSAR) was found for predicting the pseudo-first-order reaction rate constant of the alkylating chemical 4-nitrobenzylpyridine with a set of epoxides. The superdelocalizability of the unoccupied levels of the orbital along the carbon-oxygen bond of the least substituted carbon was found to be an excellent ...
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