Results 71 to 80 of about 12,546 (159)

CD27 and ICOS as Targets of PD‐1/PD‐L1 Signaling to Regulate Resident Memory CD8+ T‐Cell‐Mediated Pulmonary Protection and Pathology

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Here it is revealed that the costimulatory receptors CD27 and ICOS are essential for the long‐term maintenance of PD‐1high CD8+ TRM cells following influenza infection. PD‐L1 blockade enhances the proliferation and activation of these cells through Nur77 activation downstream of the CD27/ICOS signaling axis, thereby boosting host immunity against ...
Yuanyuan Chen, Zhenzhen Wang, Liqiang Song, Qianqian Chen, Hang Zhang, Tao Pan, Jianli Pan, Sheng Zhao, Ting Shang, Hong'en Xu, Xing Lv, Jing Li, Fei Kang, Yongzhan Nie, Feng Zhao, Lei Shi, Zheng Wang   +16 more
wiley   +1 more source

Type I Interferon Impairs Specific Antibody Responses Early During Establishment of LCMV Infection

Frontiers in Immunology, 2016
Elicitation of type I interferon (IFN-I) has been shown to both enhance and impair cell-mediated immune responses in acute and persistent viral infections, respectively.
Matthieu Daugan, Armstrong Murira, Barbara C Mindt, Amélie Germain, Esther Tarrab, Pascal Lapierre, Jorg Hermann Fritz, Jorg Hermann Fritz, Alain Lamarre   +8 more
doaj   +1 more source

Analysis of the Function of the Lymphocytic Choriomeningitis Virus S Segment Untranslated Region on Growth Capacity In Vitro and on Virulence In Vivo

Viruses, 2020
Lymphocytic choriomeningitis virus (LCMV) is a prototypic arenavirus. The function of untranslated regions (UTRs) of the LCMV genome has not been well studied except for the extreme 19 nucleotide residues of both the 5′ and 3′ termini. There are internal
Satoshi Taniguchi, Tomoki Yoshikawa, Masayuki Shimojima, Shuetsu Fukushi, Takeshi Kurosu, Hideki Tani, Aiko Fukuma, Fumihiro Kato, Eri Nakayama, Takahiro Maeki, Shigeru Tajima, Chang-Kweng Lim, Hideki Ebihara, Shigeru Kyuwa, Shigeru Morikawa, Masayuki Saijo   +15 more
doaj   +1 more source

NP and L Proteins of Lymphocytic Choriomeningitis Virus (LCMV) Are Sufficient for Efficient Transcription and Replication of LCMV Genomic RNA Analogs [PDF]

Journal of Virology, 2000
ABSTRACT The genome of lymphocytic choriomeningitis virus (LCMV) consists of two negative-sense single-stranded RNA segments, designated L and S. Both segments contain two viral genes in an ambisense coding strategy, with the genes being separated by an intergenic region (IGR).
K J, Lee, I S, Novella, M N, Teng, M B, Oldstone, J C, de La Torre   +4 more
openaire   +2 more sources

Overcoming challenges in CAR‐T therapy for malignancies: Mechanisms and strategies

Clinical and Translational Discovery, Volume 6, Issue 1, February 2026.
Chimeric antigen receptor T (CAR‐T) cell therapy faces three major challenges: tumour‐intrinsic resistance mechanisms, limitations in CAR‐T cell efficacy and immunosuppressive tumour microenvironment (TME) effects. Emerging strategies address these hurdles through precision targeting enhancement, optimised CAR‐T cell persistence/functionality and TME ...
Yushan Huang, Jun Long, Changpeng Yang, Wang Lu, Husheng Mei, Wenbin Qian, Jing Yang, Aibin Liang   +7 more
wiley   +1 more source

Quantitative and qualitative analysis of bone marrow CD8+ T cells from different bones uncovers a major contribution of the bone marrow in the vertebrae.

Frontiers in Immunology, 2016
Bone marrow (BM) plays an important role in the long-term maintenance of memory T cells. Yet, BM is found in numerous bones throughout the body, which are not equal in structure, as they differ in their ratio of cortical and trabecular bone. This implies,
Sulima eGeerman, Sarah eHickson, Giso eBrasser, Maria Fernanda Pascutti, Martijn A. Nolte   +4 more
doaj   +1 more source

A specific microbial consortium enhances Th1 immunity, improves LCMV viral clearance but aggravates LCMV disease pathology in mice

Nature Communications
Abstract Anti-viral immunity can vary tremendously from individual to individual but mechanistic understanding is still scarce. Here, we show that a defined, low complex bacterial community (OMM12) but not the general absence of microbes in germ-free mice leads to a more potent immune response compared to the microbiome of specific-pathogen ...
Daphne Kolland, Miriam Kuhlmann, Gustavo P. de Almeida, Amelie Köhler, Anela Arifovic, Alexandra von Strempel, Mohsen Pourjam, Silvia Bolsega, Christine Wurmser, Katja Steiger, Marijana Basic, Klaus Neuhaus, Carsten B. Schmidt-Weber, Bärbel Stecher, Dietmar Zehn, Caspar Ohnmacht   +15 more
openaire   +3 more sources

Independent Lineage of Lymphocytic Choriomeningitis Virus in Wood Mice (Apodemus sylvaticus), Spain

Emerging Infectious Diseases, 2009
To clarify the presence of lymphocytic choriomeningitis virus (LCMV) in Spain, we examined blood and tissue specimens from 866 small mammals. LCMV RNA was detected in 3 of 694 wood mice (Apodemus sylvaticus).
Juan Ledesma, Cesare Giovanni Fedele, Francisco Carro, Lourdes Lledó, María Paz Sánchez-Seco, Antonio Tenorio, Ramón Casimiro Soriguer, José Vicente Saz, Gerardo Domínguez, María Flora Rosas, Jesús Félix Barandika, María Isabel Gegúndez   +11 more
doaj   +1 more source

Decoding the Self: Single‐Trial Prediction of Self‐Boundary Meditation States From Magnetoencephalography Recordings

Human Brain Mapping, Volume 47, Issue 1, January 2026.
Meditation‐induced self‐boundary dissolution can be predicted from magnetoencephalography recordings using Lempel‐Ziv complexity and oscillatory power as neural markers. We demonstrate significantly above‐chance classification of altered self‐experience on a single‐trial basis and show that it is mediated by complex activation patterns across brain ...
Henrik Röhr, Daniel A. Atad, Fynn‐Mathis Trautwein, Pedro A. M. Mediano, Yair Dor‐Ziderman, Yoav Schweitzer, Aviva Berkovich‐Ohana, Stefan Schmidt, Marieke K. van Vugt   +8 more
wiley   +1 more source

The re-emergence and evolution of lymphocytic choriomeningitis virus in Germany

International Journal of Infectious Diseases
Introduction: Lymphocytic choriomeningitis virus (LCMV; species Mammarenavirus choriomeningitidis), a zoonotic pathogen transmitted by house mice (Mus musculus), is the only globally distributed arenavirus.
Mr Calvin Mehl, Claudia Wylezich, Olayide Abraham Adeyemi, Fiona Joana Möhrer, Romy Kerber, Daniel Cadar, Lisa Oestereich, Christina Geiger, Nicole Schauerte, Kerstin Mätz-Rensing, Anne Nesseler, Katja Schmidt, Dirk Höper, Miriam Linnenbrink, Martin Beer, Gerald Heckel, Rainer G. Ulrich   +16 more
doaj   +1 more source