Results 1 to 10 of about 6,793 (233)

Exploring imaging features of molecular subtypes of large cell neuroendocrine carcinoma (LCNEC) [PDF]

Lung Cancer, 2020
Radiological characteristics and radiomics signatures can aid in differentiation between small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC). We investigated whether molecular subtypes of large cell neuroendocrine carcinoma (LCNEC), i.e. SCLC-like (with pRb loss) vs.
Casale, R, Derks, JL, Dingemans, AMA, Gietema, HA, Hekkelman - Ten Berge, Deirdre, Hermans, BCM, Hillen, LM, Hoesein, FM, Jong, EM, Lambin, P, Sanduleanu, S, Speel, EJ, Woodruff, H   +12 more
core   +9 more sources

Treatment of Advanced-Stage Large Cell Neuroendocrine Cancer (LCNEC) of the Lung: A Tale of Two Diseases [PDF]

Frontiers in Oncology, 2021
LCNEC of the lung comprises a small proportion of pulmonary malignancies. Traditionally, they have been classified based on histologic and immunohistochemistry characteristics with features of small cell and non-small cell lung cancer.
Tahani Atieh, Chao H. Huang, Chao H. Huang   +2 more
doaj   +2 more sources

Large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder: a case report [PDF]

Diagnostic Pathology, 2013
Abstract Neuroendocrine carcinoma of the urinary bladder is a rare entity, accounting less then 1% of urinary bladder malignancies. The vast majority of the neuroendocrine carcinoma of the urinary bladder is represented by small cell neuroendocrine carcinoma while just few cases of large cell neuroendocrine carcinoma (LCNEC) have been ...
Cristina Colarossi, Piero Pino, Dario Giuffrida, Eleonora Aiello, Rosario Costanzo, Daniela Martinetti, Lorenzo Memeo   +6 more
openalex   +4 more sources

Large Cell Neuroendocrine Cancer (LCNEC) of Uterine Cervix

Ibrahim Medical College Journal, 1970
A rare type of cervical cancer was encountered as a neuroendocrine cancer of cervix. Clinically, the patient presented with bleeding per vagina. She refused biopsy in her first visit and did not come for follow up. However, after few months she came and since there was a polypoid growth from cervix, she was advised to undergo hysterectomy ...
Gehanath Baral, Reetu Sharma
openalex   +4 more sources

Clinicopathologic Disease Characteristics and Their Association with Adjuvant Chemotherapy Outcomes in Pulmonary Large-Cell Carcinoma Patients with or Without Neuroendocrine Features [PDF]

Diagnostics
Background: Large-cell carcinoma (LCC) and large-cell neuroendocrine carcinoma (LCNEC) are kinds of rare lung tumors classified as distinct forms of non-small-cell lung cancer (NSCLC).
Doğan Bayram, Oznur Bal, Efe Cem Erdat, Serhat Sekmek, Saliha Yılmaz, Perihan Perkin, Süleyman Gökalp Güneş, Efnan Algin, Bülent Mustafa Yenigün   +8 more
doaj   +2 more sources

Is CK7 a Prognostic Marker in Pulmonary LCNEC? Evidence from a Limited Cohort Study [PDF]

Journal of Personalized Medicine
Objectives: While the treatment of non-small-cell lung carcinoma has improved rapidly, the treatment of pulmonary large-cell neuroendocrine carcinoma (LCNEC) remains underdeveloped. The use of immunohistochemistry allows for accurate risk stratification.
Hruy Menghesha, D Zalepugas, Amina Camo, Georg Schlachtenberger, Konstantinos Grapatsas, Andres Amorin Estremadoyro, Fabian Doerr, Matthias Heldwein, Alexander Quaas, Servet Bölükbas, Gerardus Bennink, Joachim Schmidt, Khosro Hekmat   +12 more
openalex   +3 more sources

DLL3 expression in large cell neuroendocrine carcinoma (LCNEC) and association with molecular subtypes and neuroendocrine profile [PDF]

Lung Cancer, 2019
For stage IV pulmonary large cell neuroendocrine carcinoma (LCNEC), the only therapeutic option is palliative chemotherapy. DLL3 is a new therapeutic target, which seems to be often expressed in SCLC and LCNEC. It has recently been reported that DLL3 mRNA expression is particularly upregulated in the LCNEC subgroup with STK11/KEAP1 and TP53 co ...
B.C.M. Hermans, Jules L. Derks, Erik Thunnissen, Robert Jan van Suylen, Michael A. den Bakker, Harry J.M. Groen, Egbert F. Smit, Ronald Damhuis, Esther C. van den Broek, Andrea Rüland, Ernst‐Jan M. Speel, Anne‐Marie C. Dingemans   +11 more
openalex   +6 more sources

Gynecologic large cell neuroendocrine carcinoma: A review [PDF]

Rare Tumors, 2020
Large cell neuroendocrine carcinomas (LCNEC) are rare, aggressive high-grade neuroendocrine neoplasms within the neuroendocrine cell lineage spectrum. This manuscript provides a detailed review of published literature on LCNEC of gynecological origin. We
Grant Burkeen, Aman Chauhan, Rohitashva Agrawal, Riva Raiker, Jill Kolesar, Lowell Anthony, B. Mark Evers, Susanne Arnold   +7 more
doaj   +3 more sources

DLL3 expression is a predictive marker of sensitivity to adjuvant chemotherapy for pulmonary LCNEC [PDF]

Thoracic Cancer, 2020
Background The mammalian Notch family ligands delta‐like 3 (DLL3) is reported to be a potential therapeutic target for large cell neuroendocrine carcinomas (LCNEC). The effect of DLL3 expression on LCNEC prognosis has not yet been elucidated.
Hiroyuki Ogawa, Yasuhiro Sakai, Wataru Nishio, Yusuke Fujibayashi, Megumi Nishikubo, Yuki Nishioka, Shinya Tane, Yoshitaka Kitamura, Tamotsu Sudo, Toshiko Sakuma, Masahiro Yoshimura   +10 more
doaj   +3 more sources

Management of Large Cell Neuroendocrine Carcinoma [PDF]

Frontiers in Oncology, 2021
BackgroundLarge cell neuroendocrine carcinoma (LCNEC) is a rare, aggressive cancer with a dismal prognosis. The majority of cases occur in the lung and the gastrointestinal tract; however, it can occur throughout the body.
Virginia Corbett, Susanne Arnold, Lowell Anthony, Aman Chauhan   +3 more
doaj   +3 more sources