Results 41 to 50 of about 6,793 (233)

MEN1 Gene mutation and reduced expression are associated with poor prognosis in pulmonary carcinoids [PDF]

, 2014
Context: MEN1 gene alterations have been implicated in lung carcinoids, but their effect on gene expression and disease outcome is unknown. Objective: Our objective was to analyze MEN1 gene and expression anomalies in lung neuroendocrine neoplasms and ...
Corbo, Vicenzo, Gatti, Gaia, Henfling, Mieke ER, Papotti, Mauro, Perren, Aurel, Ramaekers, Frans CS, Scarpa, Aldo, Speel, Ernst-Jan M, Swarts, Dorian RA, Van Criekinge, Wim, van Engeland, Manon, Volante, Marco   +11 more
core   +3 more sources

"Pure" large cell neuroendocrine carcinoma of the gallbladder. Report of a case and review of the literature [PDF]

, 2016
Primary Neuroendocrine Tumours (NETs) of the gallbladder are rare. Among all NETs of the gallbladder, large cell neuroendocrine carcinoma (LCNEC) is exceedingly rare. In most of the cases LCNECs are combined with other histological components.
BUSCEMI, Giuseppe, Buscemi, Salvatore, DAMIANO, Giuseppe, LO MONTE, Attilio Ignazio, MARRAZZO, Antonio, ORLANDO, Elisabetta, PALUMBO, Vincenzo Davide, PORTELLI, Francesca, VALENTINO, Alessandro   +8 more
core   +1 more source

Long‐term survivor of pulmonary combined large cell neuroendocrine carcinoma treated with nivolumab

Thoracic Cancer, 2020
Several authors have previously reported that patients with pulmonary combined large cell neuroendocrine cancer ( LCNEC) have a poor prognosis and there is no consensus on the treatment strategy for combined LCNEC as well as LCNEC.
Risa Oda, Katsuhiro Okuda, Yoriko Yamashita, Tadashi Sakane, Tsutomu Tatematsu, Keisuke Yokota, Katsuhiko Endo, Ryoichi Nakanishi   +7 more
doaj   +1 more source

Combined large cell neuroendocrine carcinoma, lung adenocarcinoma, and squamous cell carcinoma: a case report and review of the literature

Journal of Cardiothoracic Surgery, 2023
Background Combined large cell neuroendocrine carcinoma (C-LCNEC) has a poor prognosis and there is no consensus about the treatment regimen for both LCNEC and C-LCNEC patients. Case presentation The patient was a 47-year-old female who received surgical
Zirui Zhu, You Liu, Hengliang Xu, Haoyong Ning, Yanmin Xia, Leilei Shen   +5 more
doaj   +1 more source

Successful Treatment of ALK-Positive Large-Cell Neuroendocrine Carcinoma of the Lung With Sequential ALK Inhibitors: A Case Report

JTO Clinical and Research Reports, 2023
ALK-positive large-cell neuroendocrine carcinoma (LCNEC) is an exceptionally rare form of lung cancer. The efficacy of ALK inhibitors in treating ALK-positive LCNEC remains unclear. Here, we report a case of ALK-positive LCNEC of the lung, which revealed
Takayuki Kobayashi, MD, Yuji Uehara, MD, Kageaki Watanabe, MD, Tsunekazu Hishima, MD, Yukio Hosomi, MD   +4 more
doaj   +1 more source

Chemotherapy for pulmonary large cell neuroendocrine carcinomas: Does the regimen matter? [PDF]

, 2017
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Bakker, M.A. (Michael) den, Damhuis, R.A. (Ronald), Derks, J.L. (Jules L.), Dingemans, A.M.C. (Anne-Marie), Groen, H.J.M. (Henk), Smit, E.F. (Egbert), Speel, E.J. (Ernst-Jan), Suylen, R-J. (Robert-Jan) van, Thunnissen, E. (Erik), Van Den Broek, E.C. (Esther C.)   +9 more
core   +1 more source

N-staging in large cell neuroendocrine carcinoma of the lung: diagnostic value of [18F]FDG PET/CT compared to the histopathology reference standard

EJNMMI Research, 2021
Background Large cell neuroendocrine carcinoma of the lung (LCNEC) is a rare entity occurring in less than 4% of all lung cancers. Due to its low differentiation and high glucose transporter 1 (GLUT1) expression, LCNEC demonstrates an increased glucose ...
Hubertus Hautzel, Yazan Alnajdawi, Wolfgang P. Fendler, Christoph Rischpler, Kaid Darwiche, Wilfried E. Eberhardt, Lale Umutlu, Dirk Theegarten, Martin Stuschke, Martin Schuler, Clemens Aigner, Ken Herrmann, Till Plönes   +12 more
doaj   +1 more source

Bayesian hierarchical clustering for studying cancer gene expression data with unknown statistics [PDF]

, 2013
Clustering analysis is an important tool in studying gene expression data. The Bayesian hierarchical clustering (BHC) algorithm can automatically infer the number of clusters and uses Bayesian model selection to improve clustering quality. In this paper,
A Su, B Frey, C Nutt, C Rasmussen, C Rasmussen, D Arango, D Jiang, D Singh, David R. J. Snead, E Cooke, Ferdinando Di Cunto, G Brock, J Ihmels, J Yao, K Yeung, Korsuk Sirinukunwattana, L Hubert, L McQuitty, LF Wu, M De Souto, M Eisen, M Shipp, Muhammad F. Bari, Nasir M. Rajpoot, P D'haeseleer, P Laiho, R Neal, R Savage, R Sokal, Richard S. Savage, S Armstrong, S Datta, S Eschrich, S Falcon, S Matsui, S Pomeroy, S Ramaswamy, S Varambally, T Golub, Y Wang   +39 more
core   +4 more sources

Comparison of genomic landscapes of large cell neuroendocrine carcinoma, small cell lung carcinoma, and large cell carcinoma

Thoracic Cancer, 2019
Background The classification of large cell neuroendocrine carcinoma (LCNEC) has generated considerable debate and has been revised since its recognition as a separate entity. Although it shares clinical features with small cell lung carcinoma (SCLC) and
Zhen Zhou, Lei Zhu, Xiaomin Niu, Shengping Shen, Yi Zhao, Jie Zhang, Junyi Ye, Han Han‐Zhang, Junjun Liu, Chenglin Liu, Shun Lu   +10 more
doaj   +1 more source

Large Cell Neuro-Endocrine Carcinoma of the Lung: Current Treatment Options and Potential Future Opportunities

Frontiers in Oncology, 2021
Large-cell neuroendocrine carcinomas of the lung (LCNECs) are rare tumors representing 1–3% of all primary lung cancers. Patients with LCNEC are predominantly male, older, and heavy smokers.
Miriam Grazia Ferrara, Miriam Grazia Ferrara, Alessio Stefani, Alessio Stefani, Michele Simbolo, Sara Pilotto, Maurizio Martini, Filippo Lococo, Emanuele Vita, Emanuele Vita, Marco Chiappetta, Alessandra Cancellieri, Ettore D’Argento, Ettore D’Argento, Rocco Trisolini, Guido Rindi, Aldo Scarpa, Stefano Margaritora, Michele Milella, Giampaolo Tortora, Giampaolo Tortora, Emilio Bria, Emilio Bria   +22 more
doaj   +1 more source