Results 121 to 130 of about 44,701 (203)

Are Tetrapleura tetraptera Phytochemicals Druggable Against SARS‐CoV‐2 Papain‐Like Protein? A Computational Approach

New Zealand Journal of Botany, Volume 64, Issue 1, March 2026.
SARS‐CoV2 Omicron and its substrains are still a critical global health issue and extremely contagious, even with widespread vaccination efforts. Hospitalizations and mortality rates linked to these variants are still prevalent. Current therapeutic options face challenges, including low effectiveness, suboptimal pharmacokinetics, and drug resistance ...
Frank Eric Tatsing Foka, Hazel Tumelo Mufhandu   +1 more
wiley   +1 more source

Dual Inhibition of COX‐2/5‐LOX Through Novel Hybrids of NSAIDs and Peptides: Insights from Molecular Dynamics Simulation and Per‐Residue Decomposition

ChemistryOpen, Volume 15, Issue 3, March 2026.
Hybrid NSAID–aminoacid molecules have demonstrated excellent activity in inhibiting the cyclooxygenase/lipoxygenase system. Accordingly, the present study describes the synthesis of molecules of this kind, examining their behavior via docking, molecular dynamics simulations and per‐residue energy decomposition analyses.
J. Carlos Jiménez‐Cruz, Ramón Guzmán‐Mejía, Pedro Navarro‐Santos, Hugo A. García‐Gutiérrez, Julio C. Ontiveros‐Rodríguez, Rafael Herrera‐Bucio, Verónica Cortés‐Muñoz, Judit A. Aviña‐Verduzco   +7 more
wiley   +1 more source

Assessing the safety of two organosulfur compounds derived from onion in western honey bee (Apis mellifera). [PDF]

Sci Rep
Falcón-Piñeiro A, Baños A, Martín-Hernández R, Higes M.   +3 more
europepmc   +1 more source

Novel Pyrimidine‐5‐Carbonitriles as Potential Green and Sustainable Corrosion Inhibitor for Mild Steel in Acidic Medium: Experimental and Theoretical Approaches

ChemistrySelect, Volume 11, Issue 11, 18 March 2026.
ABSTRACT In this study, three pyrimidine‐5‐carbonitrile derivatives (PNs) were synthesized using a one‐pot multicomponent reaction involving malononitrile, aromatic aldehydes, and an amidine derivative in an aqueous glucose solution as a fully green medium are 2,4‐diamino‐6‐phenylpyrimidine‐5‐carbonitrile (PN‐1), 2,4‐diamino‐6‐(4‐methoxyphenyl ...
Mohammad Salman, Abdelilah El‐Khlifi, Suresh Kumar Pandey, Shailendra Kumar Singh, Lebogang Katata‐Seru, Indra Bahadur   +5 more
wiley   +1 more source

The Approximate Subcutaneous LD₅₀ and Associated Lesions Induced by Ivalin, Extracted and Purified from <i>Geigeria aspera</i> Harv., in Sprague-Dawley Rats. [PDF]

Molecules
Locke S, Botha C, Clift S, Lensink A.
europepmc   +1 more source

Death-knell for LD50? [PDF]

Nature, 1989
openaire   +1 more source

Evaluation of the Use of a Medium Cut‐Off Dialyser Theranova 400 for Severe Metaldehyde Intoxication in Three Dogs: Dialytic Clearance and Therapeutic Response

Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.
Three dogs with severe neurological signs from acute metaldehyde intoxication were treated with emergent haemodialysis using a medium cut‐off (MCO) dialyser. Neurological signs resolved within a single 4‐h session without adverse effects. Dialytic clearance of metaldehyde was 12.5 times higher than intrinsic clearance, demonstrating the clinical ...
Maxime Rodary, Claudia Iannucci, Andreas F. Lehner, Birgit Puschner, John P. Buchweitz, Alessio Vigani   +5 more
wiley   +1 more source

Therapeutic Potential of GYY4137 in Reducing Oxidative Stress and Mortality in Experimental Decompression Sickness. [PDF]

Sci Rep
Daubresse L, Marlinge M, Lavner H, Dodivers JS, Bertaud A, Lledo S, Conte S, Fromonot J, Gastaldi M, Risso JJ, Rostain JC, Blatteau JE, Vallee N, Guieu R, Guieu R.   +14 more
europepmc   +1 more source

Oral Acute Toxicity and Genotoxicity of Heteroctenus junceus Scorpion Venom

Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.
The Heteroctenus junceus scorpion venom is a very popular natural extract used in traditional medicine in Cuba. In clinically relevant experimental settings, scorpion venom does not induce general toxicity or an increase in the frequency of micronucleus formation in erythrocytes.
Alexis Díaz‐García, Jenny Laura Ruiz‐Fuentes, Sophia Mejias Medina, Nicolas Zapata Guajardo, Christian Ross Skarneo   +4 more
wiley   +1 more source

A Compound Fungicide Impairs Cognitive Performance in Honey Bees (Apis mellifera). [PDF]

Insects
Zhang X, Cao Q, Sun Q, Tian Y, Du Y, Guo Y.   +5 more
europepmc   +1 more source