Results 131 to 140 of about 61,903 (248)

Pharmacokinetics and Acute Safety Evaluation of Tryptanthrin, A Bioactive Constituent of Indigo naturalis, Following Intravenous Administration in Mice

Journal of Applied Toxicology, Volume 46, Issue 10, Page 3498-3505, October 2026.
ABSTRACT The use of Indigo naturalis in treating inflammatory diseases is clinically restricted by severe adverse events, including pulmonary arterial hypertension and hepatotoxicity. Tryptanthrin, a major indoloquinazoline alkaloid of Indigo naturalis, exhibits potent anti‐inflammatory activity; however, its specific safety profile relative to the ...
Hyung Jin Kim, Gabsik Yang, Jun Ho Lee
wiley   +1 more source

Bio‐guided fractionation of (9Z )‐5,8,11‐trihydroxyoctadec‐9‐enoic acid from Abelmoschus sagittifolius root as a potent α‐glucosidase inhibitor: An integrated in vitro and in silico study

Journal of the Science of Food and Agriculture, Volume 106, Issue 13, Page 7735-7746, October 2026.
Abstract BACKGROUND Abelmoschus sagittifolius stands out as a valuable medicinal source for developing functional food targeting type 2 diabetes. This study investigated the α‐glucosidase inhibitory potential of an active fraction obtained from A. sagittifolius roots (ASR), enriched in (9Z)‐5,8,11‐trihydroxyoctadec‐9‐enoic acid (OA), using both enzyme ...
Nguyen Phuong Mai, Nguyen Van Quan, Nguyen Dang Duc, Tran Dang Xuan   +3 more
wiley   +1 more source

A Trp574–Leu substitution confers resistance to three classes of acetolactate synthase inhibitors in Australian brome grass (Bromus diandrus)

Pest Management Science, Volume 82, Issue 10, Page 9437-9443, October 2026.
Target‐site based imidazolinone resistance in brome grass was found to be conferred by a mutation at position 574 in the ALS gene and to severely impact the efficacy of the herbicide Intervix®, a co‐formulation of imazamox and imazapyr. Abstract BACKGROUND Brome grass (Bromus diandrus) is a prevalent weed in southern Australian cropping regions which ...
Roberto Busi, Danica Goggin, Nick Eyres, Fabian Runge, Aimone Porri, Ken Flower   +5 more
wiley   +1 more source

Synergistic transition from type‐I‐like to type‐II‐like symptomology in a pyrethroid mixture and its impact on knockdown–mortality relationships in Musca domestica L

Pest Management Science, Volume 82, Issue 10, Page 9614-9627, October 2026.
In the present study, relationship between knockdown and mortality of insecticides was examined against the adult female housefly, Musca domestica. Type‐I pyrethroid insecticides showed a weak linkage, as early knocked down flies did not always result in mortality, while type‐II pyrethroids and organophosphates exhibited strong correlation between the ...
Junho Yoon, Jun‐Hyung Tak
wiley   +1 more source

Can pesticide acute toxicity for bumblebees be derived from honeybee LD50 values?

, 2009
contribution to session II 'Bumblebees and other bee species'International audiencePesticide acute toxicity towards animals is commonly assessed using lethal doses (LD50).
van der Steen, Joseph, Chauzat, Marie-Pierre, Bortolotti, Laura   +2 more
core   +1 more source

Cyanopeptide Mixtures Induce Variable Synergistic and Antagonistic Effects Across Diverse Human Cell Lines

Environmental Toxicology, Volume 41, Issue 10, Page 807-821, October 2026.
ABSTRACT Cyanobacterial harmful algal blooms (cyanoHABs) threaten human, animal, and ecosystem health and safety through production of toxic secondary metabolites. Microcystis, a cosmopolitan bloom‐forming cyanobacterial genus, is well‐known for producing hepatotoxic microcystins (MCs), but it can produce many other bioactive cyanopeptides, such as ...
Lauren N. Hart, Katherine L. Lev, Sierra Hefferan, Sanduni H. Premathilaka, Sharmila I. Thenuwara, Dragan Isailovic, David H. Sherman, Gregory J. Dick   +7 more
wiley   +1 more source

Uji Toksisitas Akut (LD50) Infusa Daun Kembang Mentega (Nerium Oleander Linn) Pada Mencit Jantan Secara Intraperitonial [PDF]

, 1998
Uji toksisitas akut infusa daun kembang mentega dilakukan melalui parameter LD50 untuk mengetahui besarnya dosis yang dapat menyebabkan kematian separuh dari jumlah mencit jantan dengan pemberian secara intraperitonial.
Suwardhany, Neny
core  

Rosemary metabolite carnosic acid opens Kv1.1 via its voltage sensor and corrects Kv1.1‐linked episodic ataxia in mice

British Journal of Pharmacology, Volume 183, Issue 20, Page 6179-6198, October 2026.
Background and Purpose Episodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder caused primarily by loss‐of‐function mutations in the voltage‐gated potassium channel Kv1.1 (KCNA1). Small molecules that restore Kv1.1 activity hold promise as targeted therapies for EA1, yet current pharmacological strategies remain limited ...
Rían W. Manville, Ryan F. Yoshimura, Hanh A. Nguyen, Ruiming Zhao, Derk J. Hogenkamp, Steve A. N. Goldstein, Geoffrey W. Abbott   +6 more
wiley   +1 more source

Nutritional composition of pollen stores in managed bees across European agro‐ecosystems reveals species‐specific differences but limited pesticide effects

Ecological Entomology, Volume 51, Issue 5, Page 853-865, October 2026.
In the pollen stores of three bee species deployed across 128 European sites, bumble bees harboured lower lipid content and higher protein‐to‐lipid ratios than honey bees and mason bees. Toxicity‐weighted pesticide risk did not alter protein‐to‐lipid ratios, but higher risk was associated with reduced protein and lipid content in the pollen stores of ...
Antoine Gekière, Clément Tourbez, Maryse Vanderplanck, Tomasz Kiljanek, Guillaume Ghisbain, Elif Kardas, Irene Bottero, Marie‐Pierre Chauzat, Elena Cini, Francesca Corvucci, Joachim R. de Miranda, Gennaro Di Prisco, Christophe Dominik, Francesca V. Grillenzoni, Simon Hodge, Anina Knauer, Marion Laurent, Vicente Martínez‐López, Risto Raimets, Janine M. Schwarz, Deepa Senapathi, Giorgia Serra, Giovanni Tamburini, Dimitry Wintermantel, Mark J. F. Brown, Matthias Albrecht, Cecilia Costa, Pilar De la Rúa, Alexandra‐Maria Klein, Marika Mänd, Simon G. Potts, Maj Rundlöf, Oliver Schweiger, Jane C. Stout, Denis Michez   +34 more
wiley   +1 more source

Chronic LD50 of Coconut Oil

Sokoto Journal of Medical Laboratory Science, 2019
Coconut oil is edible and it is obtained from the kernel of mature coconuts of the coconut palm. It has been used in skin and hair care products as well as for the relief of stress, weight loss, cholesterol level maintenance, cardiovascular diseases and ...
Ojianwuna, C.C. , Mokogwu A.T.H. , Avwioro O.G.* , Nwambuonwor C.C. , Ojidere, C.H.
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