Results 91 to 100 of about 370,495 (313)
Efficacy and Safety of Alirocumab as Add-on Therapy in High–Cardiovascular-Risk Patients With Hypercholesterolemia Not Adequately Controlled With Atorvastatin (20 or 40 mg) or Rosuvastatin (10 or 20 mg)::Design and Rationale of the ODYSSEY OPTIONS Studies [PDF]
, 2014 The phase 3 ODYSSEY OPTIONS studies (OPTIONS I, NCT01730040; OPTIONS II, NCT01730053) are multicenter, multinational, randomized, double-blind, active-comparator, 24-week studies evaluating the efficacy and safety of alirocumab, a fully human monoclonal ...
Peter H. Jones +13 more
core +1 more source
Advanced Science, EarlyView.A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang +10 more
wiley +1 more source
Атеросклероз, 2018 In the review, modern views on the significant role of hypercholesterolemia (HCH), especially familial HCH, hypertriglyceridemia and hyperglycemia in the onset and development of coronary heart disease (CHD) and its complications (myocardial infarction ...
M. P. Yachmeneva, Yu. I. Ragino
doaj +1 more source
Advanced Science, EarlyView.The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian +9 more
wiley +1 more source
The Cholesterol Lowering Effects of Eurycoma longifolia Jack (Tongkat Ali) Root Extract in Male Rats
Makara Journal of Health Research, 2017 Background: To investigate the effect of Eurycoma longifolia Jack root extract on serum lipids in rats. Methods: Twenty-six mature male albino Wistar rats were used in this study.
Ghasak G. Faisal +3 more
doaj +1 more source
SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition
Advanced Science, EarlyView.Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo +14 more
wiley +1 more source
Advanced Science, EarlyView.The TPR‐LYTACs nanomaterial offers a dual‐pathway strategy for precise gouty arthritis treatment by targeting and degrading the ROS‐producing enzyme NOX2 inside macrophages while its antioxidant core clears accumulated ROS outside. This “source inhibition and microenvironment scavenging” approach, guided by NIR‐II imaging, effectively controls local ...
Jian Zhang +15 more
wiley +1 more source
LDL-c and NAFLD in the non-obese population
, 2016 data about NAFLD within the normal LDL-c range in non-obese subjects in cross-sectional and longitudinal population from 2010 to ...
Li-Ren Wang (3349052) +19 more
core +1 more source
Silicon Nitride Resistive Memories
Advanced Electronic Materials, EarlyView.Amorphous SiNx is an attractive resistance switching material for ReRAM applications due to its physicochemical properties, such as humidity resistance, low oxygen diffusivity, and is used as a metal diffusion blocker. By modifying the ratio between N and Si atoms, the microstructure of the SiNx is affected, rendering it possible to change the ...
Alexandros‐Eleftherios Mavropoulis +7 more
wiley +1 more source
فصلنامه دانشگاه علوم پزشکی جهرم, 2011 Introduction: Oxidation of low-density lipoprotein (LDL) has been strongly implicated in the pathogenesis of atherosclerosis. The use of antioxidant compounds in dietary food stuff including vitamin E and herbal extract such as Walnut (Juglansregia L ...
Hassan Ahmadvand +5 more
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