Results 71 to 80 of about 405,931 (255)

Isolation and in-vitro oxidation of human low density lipoproteins

International Journal of Medicine and Health Development, 1998
The role of low density lipoproteins (LDL) in the pathogensis of atherosclerosis has been gaining increasing importance. It is well accepted that LDL in their modified (i.e.
J C Igweh, N Leitinger, Rodregues Magarida, H Sinzinger   +3 more
doaj  

Towards an Open Architecture for LDL

, 1989
We extend LDL to allow programs to call external procedures and vice versa. This extension allows the modularization of LDL, since external predicates are equivalent to external procedures written in LDL.
Ravi Krishnamurthy, An Ldl, Danette Chimenti, Ruben Gamboa   +3 more
core  

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Beneficial influence of low-density lipoprotein cholesterol on the endothelium in relation to endothelial repair

Environmental Health and Preventive Medicine
Background: Low-density lipoprotein cholesterol (LDLc) is regarded as a risk factor for endothelial dysfunction. However, LDLc stimulates the proliferation of hematopoietic stem cells (CD34-positive cells), which contribute to endothelial repair ...
Yuji Shimizu, Shin-Ya Kawashiri, Hirotomo Yamanashi, Seiko Nakamichi, Naomi Hayashida, Yasuhiro Nagata, Takahiro Maeda   +6 more
doaj   +1 more source

Honey improves lipid profile of diet-induced hypercholesterolemic rats

Universa Medicina, 2016
Background Coronary heart disease (CHD) is a major cause of morbidity and mortality throughout the world, including Indonesia. One of the risk factors for CHD is hypercholesterolemia.
Titis Nurmasitoh, Miranti Dewi Pramaningtyas   +1 more
doaj   +1 more source

Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo

Advanced Science, EarlyView.
As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao, Zhijin Tian, Luqi Weng, Kun Xu, Dingyi Han, Zhaowei Wu, Junnan Li, Shangpu Li, Qijing Zhang, Xiaohui Zhao, Guoling Li, Yinghui Wei, Zhen Gu   +12 more
wiley   +1 more source

Efek minyak ikan toman (Channa micropeltes) terhadap kadar profil lipid mencit jantan (Mus musculus) model dislipidemia

Majalah Kedokteran Andalas, 2019
Tujuan: Untuk mengetahui efek minyak ikan toman (Channa micropeltes) terhadap profil lipid pada mencit jantan (Mus musculus). Metode: Penelitian ini adalah eksperimental laboratorium menggunakan rancangan randomized pre- dan post-test dengan menggunakan ...
Sadakata Sinulingga, Aprilia Putri, Intan Rahma Dewi, Melina Indah Sari, Mutiara Budi Azhar, Tri Suciati, Mariana Mariana, Subandrate Subandrate   +7 more
doaj   +1 more source

DataSheet1_Diterpenoids inhibit ox-LDL-induced foam cell formation in RAW264.7 cells by promoting ABCA1 mediated cholesterol efflux.PDF

, 2023
Introduction: Atherosclerosis is the main cause of many cardiovascular diseases and contributes to morbidity and mortality worldwide. The formation of macrophage-derived foam cells plays a critical role in the early stage of atherosclerosis pathogenesis.
Xuewen Wu (11766797), Ruipu Zhang (4485034), Weilie Xiao (2735008), Guang Cao (2165698), Pengmin Shi (14392119), Qianlang Feng (14392122), Jinyuan Huang (14392125), Cheng Zhang (70708), Hongyu Ma (212546), Fei Fang (64051), Shuang Zhao (484057), Xinting Xu (14392128), Xu Ji (343848)   +12 more
core   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

THE ROLE OF HYPERLIPIDEMIA AND HYPERGLICEMIA IN THE DEVELOPMENT OF CORONARY HEART DISEASE IN YOUNG POPULATION

Атеросклероз, 2018
In the review, modern views on the significant role of hypercholesterolemia (HCH), especially familial HCH, hypertriglyceridemia and hyperglycemia in the onset and development of coronary heart disease (CHD) and its complications (myocardial infarction ...
M. P. Yachmeneva, Yu. I. Ragino
doaj   +1 more source