Results 61 to 70 of about 750,498 (385)

Generic mechanism for generating a liquid-liquid phase transition [PDF]

, 2001
Recent experimental results indicate that phosphorus, a single-component system, can have two liquid phases: a high-density liquid (HDL) and a low-density liquid (LDL) phase.
A Voronel, AK Soper, Anna Skibinsky, C Caccamo, D Levesque, DJ Lacks, E Velasco, EA Jagla, FH Stillinger, G Stell, Giancarlo Franzese, Gianpietro Malescio, H. Eugene Stanley, HJC Berendsen, I Saika-Voivod, JM Kincaid, JN Glosli, KK Mon, M Silbert, M van Thiel, M-C Bellissent-Funel, MHJ Hagen, MR Sadr-Lahijany, O Mishima, P Rein ten Wolde, PG Debenedetti, PG Debenedetti, PH Poole, PT Cummings, Sergey V. Buldyrev, SH Behrens, VV Brazhkin, VV Brazhkin, Y Katayam   +33 more
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials [PDF]

, 2010
Background: Lowering of LDL cholesterol with standard statin regimens reduces the risk of occlusive vascular events in a wide range of individuals. We aimed to assess the safety and efficacy of more intensive lowering of LDL cholesterol with statin ...
Alsheikh-Ali, Ara, Armitage, Athyros, Ben-Yehuda, Cannon, Cannon, Chen, Colhoun, Davidson, Davidson, de Lemos, Downs, Fellstrom, Goldstein, Grundy, Holdaas, Iso, Kjekshus, Knopp, Koren, LaRosa, Nakamura, Pedersen, Pedersen, Ridker, Ridker, Sacks, Serruys, Sever, Shepherd, Shepherd, Stamler, Wanner   +33 more
core   +2 more sources

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Comparison of common cardiac factors among addicted and non-addicted older adults in Birjand

مجله دانشگاه علوم پزشکی بیرجند, 2023
Background and Aims: Age-related aspects of addiction are one of the most important public health challenges in the world and also in Iran. Therefore, the present study aimed to compare the level of common cardiac factors in addicted and non-addicted ...
Zeinab Arezomandanmofrad, Fatemeh Salmani, Farshad Sharifi, Mitra Moodi, Zoya Tahergorabi   +4 more
doaj  

Investigation of oxidative stress index and lipid profile in cattle with brucellosis [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2017
The aim of this study was to define the oxidative-antioxidative capacity and lipid profile in cattle with brucellosis. A total of 32 cattle of Simmental breed were used in the study, among those, 22 demonstrated microbiologically positive for brucellosis
Oğuz MERHAN, Kadir BOZUKLUHAN, Mushap KURU, Fatih BÜYÜK, Özkan ÖZDEN, Abdulsamed KÜKÜRT   +5 more
doaj   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

High-Fat Diet Increases Serum HDL, but Not for LDL and HDL/LDL Ratio in MICE

Folia Medica Indonesiana, 2021
The use of a ketogenic diet with an increased proportion of fat is rampant lately, both as a therapy or even lifestyle. The use of a ketogenic diet is feared to cause dyslipidemia. It will also lead to atherosclerosis and thrombosis.
Iqbal Laksana, Purwo Sri Rejeki, Lilik Herawati, Mohammad Anam Al Arif, Indrayuni Lukitra Wardhani   +4 more
doaj   +1 more source

The Prevalence of Meeting A1C, Blood Pressure, and LDL Goals Among People With Diabetes, 1988–2010

Diabetes Care, 2013
OBJECTIVE To determine the prevalence of people with diabetes who meet hemoglobin A1c (A1C), blood pressure (BP), and LDL cholesterol (ABC) recommendations and their current statin use, factors associated with goal achievement, and changes in the ...
Sarah Stark Casagrande, J. Fradkin, S. Saydah, Keith F. Rust, C. Cowie   +4 more
semanticscholar   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

FEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna, Richard Buchal, Martin Leníček, Amit Shachak, Jan Pláteník   +4 more
wiley   +1 more source