Results 151 to 160 of about 239,372 (260)

Low LDL-Cholesterol and Hemorrhagic Risk: Mechanistic Insights and Clinical Perspectives. [PDF]

Int J Mol Sci
Siniscalchi C, Basaglia M, Meschi T, Imbalzano E, Futura Bernardi F, Perrella A, Trama U, Passannanti A, Di Micco P, Schiano C.   +9 more
europepmc   +1 more source

The Role and Therapeutic Potential of Voltage‐Gated Potassium Channel Kv1.3 in Metabolism‐Related Disorders

iNew Medicine, EarlyView.
ABSTRACT Over the past three decades, the global burden of common metabolic diseases such as obesity, diabetes, and atherosclerosis has steadily increased, becoming a serious public health issue that poses a major threat to human health worldwide. Potassium channels, particularly the voltage‐gated Kv1.3 subtype, serve as critical regulators of cellular
Wenjun Zhen, Junda Liu, Xixi Chen, Shi Chen, Yuanyuan Tian, Baoming Wu, Fengxia Yan   +6 more
wiley   +1 more source

Neural network model outperforms conventional equations in LDL cholesterol estimation: A comparative study of 188,887 Chinese individuals with focus on hypertriglyceridemia. [PDF]

Atheroscler Plus
Xue H, Lin Y, Liu Y, Li L, Chen P, Li M, Ji L, Xia Y.   +7 more
europepmc   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Safety and Efficacy of Achieving Very Low LDL Cholesterol Concentrations with PCSK9 Inhibitors. [PDF]

J Clin Med
Machanahalli Balakrishna A, Kaushik S, Tandalam Palanivelu S, Monther N, Ponamgi SP, Alla VM, Patil SM.   +6 more
europepmc   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, EarlyView.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

PCSK9 and coronary atherosclerosis progression beyond LDL-cholesterol in coronary artery disease patients. [PDF]

Eur J Clin Invest
Ragusa R, Rocchiccioli S, Del Turco S, Morlando A, Basta G, Scholte A, Neglia D, Caselli C.   +7 more
europepmc   +1 more source

Adipose‐derived small extracellular vesicles exacerbate microvascular dysfunction in heart failure with preserved ejection fraction via mmu‐miR‐582‐3p‐mediated Rap1b suppression

Interdisciplinary Medicine, EarlyView.
This study reveals that small extracellular vesicles (sEVs) from visceral fat compromise coronary microcirculation in a mouse model of heart failure with preserved ejection fraction (HFpEF). The SGLT2 inhibitor canagliflozin emerges as a therapeutic strategy, improving cardiac function and endothelial health.
Lu Chen, Qiuhan Wang, Mengjia Shen, Mingjue Li, Yingqi Zhu, Cankun Zheng, Siyuan Ma, Hairuo Lin, Xiaokang Fu, Rui Zhang, Jianping Bin, Yulin Liao, Qiancheng Wang   +12 more
wiley   +1 more source

Cholesterol LDL-C

, 2021
openaire   +3 more sources

A six-year longitudinal study identifies a statin-independent association between low LDL-cholesterol and risk of type 2 diabetes. [PDF]

Cardiovasc Diabetol
Lembo M, Trimarco V, Pacella D, Izzo R, Jankauskas SS, Piccinocchi R, Gallo P, Bardi L, Piccinocchi G, Morisco C, Cristiano S, Esposito G, Giugliano G, Manzi MV, Santulli G, Trimarco B.   +15 more
europepmc   +1 more source