Results 11 to 20 of about 726,279 (98)

LDL-Cholesterol Lowering of Plant Sterols and Stanols—Which Factors Influence Their Efficacy?

Nutrients, 2018
The LDL-cholesterol (LDL-C) lowering effect of plant sterols/stanols (PSS) is summarized in several meta-analyses showing a dose-response relationship with intakes of 1.5 to 3 g/day lowering LDL-C by 7.5% to 12%.
E. Trautwein, M. Vermeer, H. Hiemstra, R. T. Ras   +3 more
semanticscholar   +1 more source

Remnant cholesterol predicts cardiovascular disease beyond LDL and ApoB: a primary prevention study.

European Heart Journal, 2021
AIMS Emerging evidence suggests that remnant cholesterol (RC) promotes atherosclerotic cardiovascular disease (ASCVD). We aimed to estimate RC-related risk beyond low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apoB) in patients without
Renato Quispe, S. Martin, E. Michos, Isha Lamba, R. Blumenthal, Anum Saeed, J. Lima, R. Puri, Sarah O. Nomura, M. Tsai, J. Wilkins, C. Ballantyne, S. Nicholls, S. Jones, M. Elshazly   +14 more
semanticscholar   +1 more source

A LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption

Science, 2018
A missing link in cholesterol absorption Cholesterol is important for general health, but too much can build up in artery walls and cause cardiovascular disease.
Ying-Yu Zhang, Z. Fu, Jian Wei, Wei Qi, Gulinaer Baituola, Jie Luo, Ya-Jie Meng, Shu-Yuan Guo, H. Yin, Shi-You Jiang, Yun-Feng Li, H. Miao, Yong Liu, Yan Wang, Bo-Liang Li, Yi-tong Ma, B. Song   +16 more
semanticscholar   +1 more source

PCSK9 R46L Loss-of-Function Mutation Reduces Lipoprotein(a), LDL Cholesterol, and Risk of Aortic Valve Stenosis.

Journal of Clinical Endocrinology and Metabolism, 2016
CONTEXT Novel, low-density lipoprotein (LDL) cholesterol-lowering proprotein convertase subtilisin/kexin type-9 (PCSK9) inhibitors also lower lipoprotein(a) levels, but the effect on aortic valve stenosis and myocardial infarction is unknown ...
A. Langsted, B. Nordestgaard, M. Benn, A. Tybjærg‐Hansen, P. Kamstrup   +4 more
semanticscholar   +1 more source

A systematic review and meta-analysis of randomized controlled trials of the effect of konjac glucomannan, a viscous soluble fiber, on LDL cholesterol and the new lipid targets non-HDL cholesterol and apolipoprotein B.

American Journal of Clinical Nutrition, 2017
Background: Evidence from randomized controlled trials (RCTs) suggests the consumption of konjac glucomannan (KJM), a viscous soluble fiber, for improving LDL-cholesterol concentrations.
H. Ho, E. Jovanovski, A. Zurbau, S. Blanco Mejia, J. Sievenpiper, F. Au‐Yeung, A. Jenkins, L. Duvnjak, Lawrence A Leiter, V. Vuksan   +9 more
semanticscholar   +1 more source

LDL–cholesterol transport to the endoplasmic reticulum: current concepts

Current Opinion in Lipidology, 2016
Purpose of review In this article, we summarize the present information related to the export of LDL-derived cholesterol from late endosomes, with a focus on Nieman-Pick disease, type C1 (NPC1) cholesterol delivery toward the endoplasmic reticulum (ER ...
S. Pfisterer, J. Peränen, E. Ikonen
semanticscholar   +1 more source

Palm Oil Consumption Increases LDL Cholesterol Compared with Vegetable Oils Low in Saturated Fat in a Meta-Analysis of Clinical Trials.

Journal of NutriLife, 2015
BACKGROUND Palm oil contains a high amount of saturated fat compared with most other vegetable oils, but studies have reported inconsistent effects of palm oil on blood lipids.
Ye Sun, N. Neelakantan, Yi Wu, Rashmi Lote-Oke, A. Pan, R. V. van Dam   +5 more
semanticscholar   +1 more source

Extreme nonfasting remnant cholesterol vs extreme LDL cholesterol as contributors to cardiovascular disease and all-cause mortality in 90000 individuals from the general population.

Clinical Chemistry, 2015
BACKGROUND Increased nonfasting remnant cholesterol, like increased LDL cholesterol, is causally associated with increased risk for ischemic heart disease (IHD).
A. Varbo, J. Freiberg, B. Nordestgaard
semanticscholar   +1 more source

Proof That Lower Is Better--LDL Cholesterol and IMPROVE-IT.

New England Journal of Medicine, 2015
The so-called LDL hypothesis is the concept that excess low-density lipoprotein (LDL) cholesterol is a causal factor in the development of atherosclerotic vascular disease.
J. Jarcho, J. Keaney
semanticscholar   +1 more source

Influence of physiological changes in endogenous estrogen on circulating PCSK9 and LDL cholesterol

Journal of Lipid Research, 2015
Pharmacologically increased estrogen levels have been shown to lower hepatic and plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) levels in animals and humans.
M. Ghosh, Cecilia Gälman, M. Rudling, B. Angelin   +3 more
semanticscholar   +1 more source