Results 31 to 40 of about 965,123 (374)

Low LDL cholesterol, PCSK9 and HMGCR genetic variation, and risk of Alzheimer’s disease and Parkinson’s disease: Mendelian randomisation study

British medical journal, 2017
Objective To test the hypothesis that low density lipoprotein (LDL) cholesterol due to genetic variation in the genes responsible for LDL cholesterol metabolism and biosynthesis(PCSK9 and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), respectively) is
M. Benn, B. Nordestgaard, R. Frikke-Schmidt, A. Tybjærg-Hansen   +3 more
semanticscholar   +2 more sources

Differences in the metabolism of oxidatively modified low density lipoprotein and acetylated low density lipoprotein by human endothelial cells: inhibition of cholesterol esterification by oxidatively modified low density lipoprotein.

Journal of Lipid Research, 1989
The rate of degradation of oxidatively modified low density lipoprotein (Ox-LDL) by human endothelial cells was similar to that of unmodified low density lipoprotein (LDL), and was approximately 2-fold greater than the rate of degradation of acetylated ...
I Jialal, A Chait
doaj   +1 more source

Mechanisms of dysregulation of low-density lipoprotein receptor expression in vascular smooth muscle cells by inflammatory cytokines [PDF]

, 2006
Objective - Although inflammation is a recognized feature of atherosclerosis, the impact of inflammation on cellular cholesterol homeostasis is unclear.
Ma, KL, Moorhead, JF, Powis, SH, Ruan, XZ, Tao, JL, Varghese, Z, Wheeler, DC   +6 more
core   +1 more source

Alterations in Lipids and Adipocyte Hormones in Female-to-Male Transsexuals [PDF]

, 2010
Testosterone therapy in men and women results in decreased high-density lipoprotein cholesterol (HDL) and increased low-density lipoprotein cholesterol (LDL).
Basra, Sukhdeep S., Chandra, Prakash, Chen, Tai C., Tangpricha, Vin   +3 more
core   +5 more sources

A Comparison of Two LDL Cholesterol Targets after Ischemic Stroke.

New England Journal of Medicine, 2019
BACKGROUND The use of intensive lipid-lowering therapy by means of statin medications is recommended after transient ischemic attack (TIA) and ischemic stroke of atherosclerotic origin.
P. Amarenco, Jong－Suk Kim, J. Labreuche, Hugo Charles, J. Abtan, Y. Béjot, L. Cabrejo, J. Cha, G. Ducrocq, M. Giroud, C. Guidoux, Cristina Hobeanu, Yong-Jae Kim, B. Lapergue, Philippa C. Lavallée, Byung‐Chul Lee, K. Lee, D. Leys, M. Mahagne, E. Meseguer, N. Nighoghossian, F. Pico, Y. Samson, I. Sibon, P. Steg, S. Sung, P. Touboul, E. Touzé, O. Varenne, E. Vicaut, Nessima Yelles, E. Bruckert, Treat Stroke to Target Investigators   +32 more
semanticscholar   +1 more source

Cholesterol delivered to macrophages by oxidized low density lipoprotein is sequestered in lysosomes and fails to efflux normally

Journal of Lipid Research, 2000
Oxidized low density lipoprotein (LDL) has been found to exhibit numerous potentially atherogenic properties, including transformation of macrophages to foam cells.
Baljinder S. Dhaliwal, Urs P. Steinbrecher   +1 more
doaj   +1 more source

Lipid levels are inversely associated with infectious and all-cause mortality: international MONDO study results. [PDF]

, 2018
Cardiovascular (CV) events are increased 36-fold in patients with end-stage renal disease. However, randomized controlled trials to lower LDL cholesterol (LDL-C) and serum total cholesterol (TC) have not shown significant mortality improvements.
Canaud, Bernard, Kaysen, George A, Kooman, Jeroen P, Kotanko, Peter, Monitoring Dialysis Outcomes (MONDO) Initiative, Raimann, Jochen G, Stuard, Stefano, Topping, Alice, Usvyat, Len A, van der Sande, Frank M, Wang, Yuedong, Ye, Xiaoling   +11 more
core   +9 more sources

Association between low-density lipoprotein cholesterol and sudden cardiac arrest in people with diabetes mellitus

Cardiovascular Diabetology, 2023
Background Dyslipidemia measured as low-density lipoprotein (LDL)-cholesterol is an established risk factor of cardiovascular disease, which is more pronounced in diabetes population.
Yun Gi Kim, Joo Hee Jeong, Kyung-Do Han, Seung-Young Roh, Kyongjin Min, Hyoung Seok Lee, Yun Young Choi, Jaemin Shim, Jong-Il Choi, Young-Hoon Kim   +9 more
doaj   +1 more source

LDL particle size and LDL and HDL cholesterol changes with dietary fat and cholesterol in healthy subjects

Journal of Lipid Research, 1998
We have conducted a dietary trial in 54 men and 51 women with a wide range of fasting cholesterol values to examine the use of low density lipoprotein (LDL) particle size to predict the lipoprotein response to dietary fat and cholesterol.
Peter M. Clifton, Manny Noakes, Paul J. Nestel   +2 more
doaj   +1 more source

Decrease of LDL Cholesterol Through The Increase of HDL Cholesterol by Administering Garcinia mangostana L. Peel Extract in White Mice

Folia Medica Indonesiana, 2021
Highlight: • Ethanol extract of Garcinia mangostana L. peel reduce malondialdehyde. • Garcinia mangostana L. peel extract can increase non-radical products which impact in decreasing LDL cholesterol and increasing HDL cholesterol.
Hasyim As'ari
doaj   +1 more source