Results 191 to 200 of about 2,527,752 (315)

Inhibition of a novel Dickkopf-1-LDL receptor-related proteins 5 and 6 axis prevents diabetic cardiomyopathy in mice. [PDF]

open access: yesEur Heart J
Ma E   +17 more
europepmc   +1 more source

LDL receptor-related protein 1 (LRP1), a novel target for opening the blood-labyrinth barrier (BLB). [PDF]

open access: yesSignal Transduct Target Ther, 2022
Shi X   +25 more
europepmc   +1 more source

Barriers and Strategies for Inclusion of Value‐Based Healthcare in Contract Negotiations in the Netherlands: Study Among Hospital and Insurer Executives

open access: yesThe International Journal of Health Planning and Management, EarlyView.
ABSTRACT Background This paper analyses why, despite its recognized importance, value‐based healthcare (VBHC) has not gained more prominence in negotiations between health insurers and hospitals in the Netherlands. Methods Data collected by interviews used a standardized questionnaire with closed‐ and open‐ended questions. Respondents included hospital
Diogo L. L. Leao   +4 more
wiley   +1 more source

Hypocholesterolemic Effects of the LDL Receptor Gene Transcriptional Upregulator CP-230821 [PDF]

open access: bronze, 1998
T. Shimokawa   +5 more
openalex   +1 more source

Extrachromosomal Circular DNA: Emerging Insights Into Cardiovascular Disease Mechanisms and Biomarker Potential

open access: yesiLABMED, EarlyView.
Extrachromosomal circular DNA (eccDNA) has quite recently turned out to be a cardinal component in cardiovascular diseases (CVD), governing the gene expression and mechanisms of disease causation. Studies indicated an upregulation of eccDNA in pulmonary arterial hypertension (PAH), which makes it strikingly potential as a sensitive and specific ...
Saim Mahmood Khan   +6 more
wiley   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

open access: yesiMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu   +8 more
wiley   +1 more source

LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation

open access: bronze, 1995
Maria Z. Kounnas   +7 more
openalex   +1 more source

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