Results 201 to 210 of about 2,591,141 (428)

Chondroitin sulfate-modified LDL induces increased cholesteryl ester synthesis and down-regulation of LDL receptors in smooth muscle cells and macrophages

Open Life Sciences, 2006
Tircol Magdalena, Tirziu Daniela, Simionescu Maya   +2 more
doaj   +1 more source

The plasma concentration of HDL-associated apoM is influenced by LDL receptor-mediated clearance of apoB-containing particles

Journal of Lipid Research, 2012
ApoM is mainly associated with HDL. Nevertheless, we have consistently observed positive correlations of apoM with plasma LDL cholesterol in humans. Moreover, LDL receptor deficiency is associated with increased plasma apoM in mice.
Christina Christoffersen, Marianne Benn, Pernille M. Christensen, Philip L.S.M. Gordts, Anton J.M. Roebroek, Ruth Frikke-Schmidt, Anne Tybjaerg-Hansen, Björn Dahlbäck, Lars B. Nielsen   +8 more
doaj  

A novel mechanism by which probucol lowers low density lipoprotein levels demonstrated in the LDL receptor-deficient rabbit.

, 1984
Marek Naruszewicz, TE Carew, R C Pittman, JL Witztum, Daniel Steinberg   +4 more
openalex   +1 more source

EFEKTIVITAS KOMBINASI DL-αTOKOFEROL DAN ASAM ASKORBAT TERHADAP KADAR LDL-OX, sCD36, sVCAM-1 DAN NO PADA ANAK SINDROM NEFROTIK [PDF]

, 2015
Latar Belakang: Stres oksidatif, disfungsi endotel dan inflamasi mendasari proses aterosklerosis pada anak sindrom nefrotik (SN). Kombinasi dl-α-tokoferol dan asam askorbat berpotensi menurunkan proses stress oksidatif dan disfungsi endotel banyak ...
MELLYANA, Omega
core  

2D-NMR reveals different populations of exposed lysine residues in the apoB-100 protein of electronegative and electropositive fractions of LDL particles[S]

Journal of Lipid Research, 2010
Several potentially atherogenic LDL subfractions present low affinity for the LDL receptor, which result in impaired plasma clearance. Electronegative LDL [LDL(−)] is one of these minor subfractions and the molecular basis for its reduced receptor ...
Francisco J. Blanco, Sandra Villegas, Sònia Benítez, Cristina Bancells, Tammo Diercks, Jordi Ordóñez-Llanos, José L. Sánchez-Quesada   +6 more
doaj  

Effect of type 2 diabetes on the inducible degrader of LDL receptor. [PDF]

J Lipid Res, 2023
Lam S, Lui DTW, Shiu SWM, Wong Y, Tan KCB.   +4 more
europepmc   +1 more source

Detection and quantitation of low density lipoprotein (LDL) receptors in human liver by ligand blotting, immunoblotting, and radioimmunoassay. LDL receptor protein content is correlated with plasma LDL cholesterol concentration.

, 1986
Anne K. Soutar, K. Harders-Spengel, David P. Wade, Brian L. Knight   +3 more
openalex   +1 more source

Target‐Mediated Modeling of Alirocumab in Adolescents and Children ≥8 to <12 Years of Age Using Phase II and III Data

Clinical Pharmacology in Drug Development, EarlyView.
Abstract A population pharmacokinetic (PK) covariate analysis was conducted utilizing data from adolescents and children ≥8 to <12 years of age with heterozygous familial hypercholesterolemia. One phase II and 1 phase III study were analyzed (121 patients on active treatment).
Pavel Kovalenko, Lutz Harnisch, Jeanne Mendell, Yuhuan Wang, John D. Davis, Albert Thomas DiCioccio   +5 more
wiley   +1 more source

The beta-VLDL receptor pathway of murine P388D1 macrophages.

Journal of Lipid Research, 1988
Very low density lipoproteins Sf 100-400 (VLDL1) from hypertriglyceridemic (HTG) subjects and chylomicrons cause receptor-mediated lipid engorgement in unstimulated macrophages in vitro via the beta-VLDL receptor pathway.
S H Gianturco, S A Brown, D P Via, W A Bradley   +3 more
doaj  

Minimally oxidized LDL inhibits macrophage selective cholesteryl ester uptake and native LDL-induced foam cell formation[S]

Journal of Lipid Research, 2014
Scavenger receptor-mediated uptake of oxidized LDL (oxLDL) is thought to be the major mechanism of foam cell generation in atherosclerotic lesions. Recent data has indicated that native LDL is also capable of contributing to foam cell formation via low ...
Jason M. Meyer, Ailing Ji, Lei Cai, Deneys R. van der Westhuyzen   +3 more
doaj