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Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects
Advanced Science, EarlyView.Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu +6 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals a metabolic signaling axis in the OSCC microenvironment where palmitic acid (PA) drives the activation of CAFs. PA uptake triggers CEBPG‐dependent epigenetic remodeling to upregulate ERN1 and TMBIM6, thereby mitigating ER stress. This adaptive program sustains CAF survival and the pro‐metastatic phenotype, establishing this pathway ...
Yiling Duan +6 more
wiley +1 more source
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Anion exchange polyelectrolytes for membranes and ionomers
Progress in Polymer Science, 2021Nanjun Chen, Young Moo Lee
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Advances and challenges in alkaline anion exchange membrane fuel cells
Progress in Energy and Combustion Science, 2018Zhefei Pan, T S Zhao
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Quantum Mechanical Exchange Coupling in Polyhydride and Dihydrogen Complexes
Chemical Reviews, 1998Sylviane Sabo-Etienne, Bruno Chaudret
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Social Exchange Theory: A Critical Review with Theoretical Remedies
Academy of Management Annals, 2017Russell Cropanzano +2 more
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Electrical Control of the Exchange Spring in Antiferromagnetic Metals
Advanced Materials, 2015Yuyan Wang, Cheng Song, Yinuo Yan
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Social Exchange Theory: An Interdisciplinary Review
Journal of Management, 2005Russell Cropanzano, Marie S Mitchell
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Two interface effects: Exchange bias and magnetic proximity
Physics Reports, 2014P K Manna, S M Yusuf, P K Manna
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