Results 91 to 100 of about 3,640,039 (291)

Towards lean and green thinking in construction projects at Gaza Strip

Organization, Technology and Management in Construction: An International Journal, 2018
Background and problem: Integrating lean and green principles while implementing construction project has become an important aspect of modern construction. Lean construction and green building are used to maxi­mize the economic benefits, address quality,
El-sawalhi Nabil I., Jaber Bilal Majid, Shukri Abed Al   +2 more
doaj   +1 more source

Lean construction

, 2008
A indústria da construção mobiliza meios consideráveis, tanto a montante como a jusante do processo de execução construtiva em si, pelo que representa uma importante parcela do Produto Interno Bruto Nacional. Sendo, em alguma medida, uma imagem do estado económico do País, a construção deve entender-se como algo essencial ao seu desenvolvimento e, como
Paula Fonseca Arantes, Jorge Moreira da Costa   +1 more
openaire   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Lean Construction – 2007 to 2016 [PDF]

, 2016
Aiming at identify main keywords of Recent Works published the annals of the International Group for Lean Construction Conference ( IGLC ) so Get a retrospective of the main ITS applications, actions and tools used lean .It was analyzed all articles ...
Monte, Carlos Eduardo, Neumann, Clóvis, Aquere, André Luiz   +2 more
core   +1 more source

Hard, soft or lean? Planning on medium size construction projects [PDF]

, 1999
In a paper presented to the 11th Annual ARCOM Conference, Johansen examined the way that managers and planners in medium sized construction projects plan in a flexible manner.
Greenwood, David, Johansen, Eric
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Review of Lean Design Management: Processes, methods and technologies

, 2017
Lean Design Management (LDM) has been used by lean practitioners to manage the design process in construction. Several methods, processes and tools have been successfully implemented, such as the Last Planner System (LPS), Target Value Design (TVD), Set ...
Antti Peltokorpi, Seppänen, Olli, Peltokorpi, Antti, Uusitalo, Petteri, Pikas, Ergo, Hylton Olivieri, Petteri Uusitalo, Olli Seppänen, Olivieri, Hylton, Ergo Pikas   +9 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source