Results 111 to 120 of about 3,640,039 (291)

The precast construction industry and lean construction tools: flow-based management strategy [PDF]

, 2022
: The Toyota Production System (TPS) formulated the referential base for the elaboration of lean construction principles, called Lean Construction and organized by Lauri Koskela, in 1992.
Riffel, Elias
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Intelligent Products: Shifting the Production Control Logic in Construction (With Lean and BIM) [PDF]

, 2015
Production management and control in construction has not been addressed/updated ever since the introduction of Critical Path Method and the Last Planner® system.
Holmström, Jan, Kubler, Silvain, Pikas, Ergo, Koskela, Lauri, Peltokorp, Antti, Dave, Bhargav, Främling, Kary, Singh, Vishal   +7 more
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Systematic review of Lean Construction: an approach to sustainability and efficiency in construction management

Journal of Infrastructure Preservation and Resilience
The construction sector is a fundamental pillar of the economy and should consequently lead in implementing effective management systems. Lean Construction (LC) philosophy sees production as a transformation, flow, and value process.
Gonzalo Garcés, Eric Forcael, Cristian Osorio, Karen Castañeda, Omar Sánchez   +4 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

A Framework for Utilising Lean Construction Strategies to Promote Safety on Construction Sites [PDF]

, 2013
A thesis submitted to the School of Technology University of Wolverhampton in partial fulfilment of the requirements for the Degree of Doctor of PhilosophyThe poor safety situation in the United Kingdom (UK) construction industry and its adverse socio ...
Bashir, Abubakar Muhammad
core   +2 more sources

A hybrid approach using entropy and TOPSIS to select key drivers for a successful and sustainable lean construction implementation. [PDF]

PLoS One, 2020
Dehdasht G, Ferwati MS, Zin RM, Abidin NZ.   +3 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

The lean journey of the finnish real estate.

Revista Ingeniería de Construcción
Nothing teaches us more than our experiences. That was the main reason why the Finnish construction industry has not only studied Lean and IPD but also launched several pilot projects by public owners to learn, adapt Lean principles in practice, and ...
Lauri Merikallio
doaj   +1 more source