Results 101 to 110 of about 319,318 (302)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Aplicação da Filosofia Lean Construction no Processo Produtivo de uma Empresa do Setor de Construção Civil

Exacta, 2017
Este artigo teve por objetivo propor melhorias para o processo produtivo de uma empresa especializada na construção de barracões e fabricação de peças em armação de concreto, através da utilização de técnicas e ferramentas da Lean Construction.
Vítor Felipe e Silva de Oliveira Nery, Izabel Cristina Zattar, Vitor Ongarato de Oliveira   +2 more
doaj   +1 more source

The 8th flow - common understanding [PDF]

, 2012
Projects are a form of engineered-to-order (ETO) production which require that the definition of Value becomes part of the production process. Project production requires the inclusion of the product design, the design process, and the production process
Pasquire, CL
core  

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Application of Lean Principles to Design Processes in Construction Consultancy Firms [PDF]

International Journal of Construction Supply Chain Management, 2011
Simulation modelling and Lean principles have both been applied in the construction industry to improve work processes. The outcomes from their implementation are outstanding and have motivated construction researchers to seek means by which other ...
Marzouk, Mohamed, Bakry, Ibrahim, El-Said, Moheeb   +2 more
doaj  

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Implementation of the 5S lean tool at a laboratory station in the road industry

Budownictwo o Zoptymalizowanym Potencjale Energetycznym
The concept of lean management is increasingly being adopted in all economic sectors around the world. The benefits of its use allow you to eliminate waste, save time, money and natural resources, while increasing the quality of the final product ...
Natalia Jagieła, José Carlos de Sá
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A Lean-Against-the-Wind Rule for Controlling Low-Skill and Illegal Immigration [PDF]

This paper develops a lean-against-the-wind rule for setting low-skill immigration quota. The construction of this rule takes into account the factors governing the supply of and demand for low-skill immigrants, illegal immigration, border enforcement ...
Faria, Joao Ricardo, Levy, Amnon
core  

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source