Results 61 to 70 of about 133,992 (290)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

“Pretending to Be Cikgu”: Role Reversal Pedagogy in Peer-Led Arabic Vocabulary Learning in Malaysia

open access: yesJournal of Arabic Language Learning and Teaching
Conventional Arabic vocabulary instruction in many Islamic secondary schools remains predominantly teacher-centered, relying heavily on memorization and teacher-led repetition, which often results in limited learner engagement, weak active retrieval, and
Masnun Masnun   +2 more
doaj   +1 more source

Understanding the bottlenecks in methodological adoption of constructivism in secondary schools in Kenya

open access: yesJPBI (Jurnal Pendidikan Biologi Indonesia), 2019
Constructivist teaching and learning approach is one of teaching approach gaining popularity based on its principles of learner centered education. This study investigated the effectiveness of constructivist method of instruction on learning biology and ...
Gideon Mwanda, Ronnie Midigo
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Instructional Theory and Technology for the New Paradigm of Education

open access: yesRED. Revista de Educación a Distancia, 2012
This article describes instructional theory that supports post-industrial education and training systems - ones that are customized and learner-centered, in which student progress is based on learning rather than time.
Charles M. Reigeluth
doaj  

The influence of humanistic education on tertiary English teachers' writing assessment practices: a systematic review

open access: yesFrontiers in Education
Past decades have witnessed a growing emphasis on aligning assessment practices with humanistic education to foster student-centered learning in EFL writing instruction.
Yumei Song   +2 more
doaj   +1 more source

Learning Progressions: An Empirically Grounded, Learner-Centered Framework to Guide Biology Instruction [PDF]

open access: yesCBE—Life Sciences Education, 2019
Vision and Change challenged biology instructors to develop evidence-based instructional approaches that were grounded in the core concepts and competencies of biology. This call for reform provides an opportunity for new educational tools to be incorporated into biology education.
Scott, Emily E.   +2 more
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Instructional Theory and Technology for the New Paradigm of Education

open access: yesRED. Revista de Educación a Distancia, 2016
This article describes instructional theory that supports post-industrial education and training systems – ones that are customized and learner-centered, in which student progress is based on learning rather than time.
Charles M. Reigeluth
doaj  

Impacts on Teacher Evaluations: The Importance of Building Capacity through Excellence in the Application of the Teacher Evaluation Process [PDF]

open access: yes, 2018
Significant student learning and school improvement are dependent upon the teacher being the centerpiece (Tucker, Stronge, Gareis, & Beers, 2003; National Council of Teacher Quality, 2011).
Bigham, Gary, Nix, Susan J.
core   +1 more source

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