Results 31 to 40 of about 71,766 (218)

Evaluating the capability of large language models in characterising relational feedback: A comparative analysis of prompting strategies

Computers and Education: Artificial Intelligence
Relational feedback is increasingly recognised for its crucial role in enhancing student-instructor relationships and promoting the assimilation of feedback.
Wei Dai, Yixin Cheng, Ahmad Ari Aldino, Yi-Shan Tsai, Dragan Gašević, Guanliang Chen   +5 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Knowledge Tracing Models in Educational Data Mining: Historical Evolution, Categorization, and Empirical Evaluation

IEEE Access
This article analyses computational models of Knowledge Tracing (KT), which address the complex sequence-modelling task of predicting dynamic, unobservable latent user states from historical interaction logs.
Prince Das Adhikary, Jari Metsamuuronen, Mikko-Jussi Laakso, Jukka Heikkonen   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Generative AI in higher education: A global perspective of institutional adoption policies and guidelines

Computers and Education: Artificial Intelligence
Integrating generative AI (GAI) into higher education is crucial for preparing a future generation of GAI-literate students. However, a comprehensive understanding of global institutional adoption policies remains absent, with most prior studies focusing
Yueqiao Jin, Lixiang Yan, Vanessa Echeverria, Dragan Gašević, Roberto Martinez-Maldonado   +4 more
doaj   +1 more source

Hidden Markov Model based stride segmentation on unsupervised free-living gait data in Parkinson’s disease patients

Journal of NeuroEngineering and Rehabilitation, 2021
Background To objectively assess a patient’s gait, a robust identification of stride borders is one of the first steps in inertial sensor-based mobile gait analysis pipelines.
Nils Roth, Arne Küderle, Martin Ullrich, Till Gladow, Franz Marxreiter, Jochen Klucken, Bjoern M. Eskofier, Felix Kluge   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source