Results 41 to 50 of about 279,125 (307)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Journal of Education and TeachingThis study examines the implementation of student-centered learning at Soran University in the Kurdistan Region and identifies factors that limit its adoption.
Saied Qadir Faqe Ibrahim +1 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Educar, 2008 En los últimos años, se ha debatido mucho sobre el nuevo modelo pedagógico que promueve el nuevo espacio de educación superior. Este artículo recoge la experiencia del Programa UNIGIS de formación a distancia en SIG, que se imparte desde la Universidad ...
Gemma Boix, Suani Armisen
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Measuring sustainability: Learning by doing
, 2020 © Simon Bell and Stephen Morse, 2003. All rights reserved.'Measuring the sustainability of development is crucial to achieving it, and is one of the most actively studied issues in the area.
Bell, S, Morse, S
core +1 more source
Developing a constructively aligned learning-by-doing (LBD) model for 21st century education at HCT, UAE [PDF]
, 2019 In the context of modern pedagogy, educators and academics have been placing greater emphasis on the value of Learning-By-Doing (LBD) and 21st Century Skills.
Frache, Ghassan
core +1 more source
Medienkompetenz durch ‹Learning by Doing›?
MedienPädagogik: Zeitschrift für Theorie und Praxis der MedienbildungLehrkräfte an berufsbildenden Schulen sollen über grundlegende Medienkompetenzen verfügen, um ihren Schüler:innen den Umgang mit digitalen Endgeräten medienpädagogisch zu vermitteln und deren Fähigkeiten und Fertigkeiten in diesem Bereich zu stärken ...
Johannes Schäfers
doaj +1 more source