Results 41 to 50 of about 1,571,252 (311)

Modelling collective learning in design

, 2004
In this paper, a model of collective learning in design is developed in the context of team design. It explains that a team design activity uses input knowledge, environmental information, and design goals to produce output knowledge.
Duffy, A.H.B., Wu, Zhichao
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Low-data interpretable deep learning prediction of antibody viscosity using a biophysically meaningful representation

Scientific Reports, 2023
Deep learning, aided by the availability of big data sets, has led to substantial advances across many disciplines. However, many scientific problems of practical interest lack sufficiently large datasets amenable to deep learning. Prediction of antibody
Brajesh K. Rai, James R. Apgar, Eric M. Bennett   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Building a school data portal using open data: A description of the user research & development process

Heliyon, 2022
The lack of relevant and disaggregated data about schools is a challenge for organizations implementing and funders looking to invest in kindergarten through 12th-grade education programs in New York City (NYC), often forcing organizations to make ...
Steven Azeka, Aankit Patel, Kenjiro Kanamaru   +2 more
doaj   +1 more source

Learning to Design RNA

CoRR, 2018
Published as a conference paper at the International Conference on Learning Representations 2019 (ICLR19)
Frederic Runge, Danny Stoll, Stefan Falkner, Frank Hutter   +3 more
openaire   +3 more sources

Learning objects, learning objectives and learning design [PDF]

Innovations in Education and Teaching International, 2008
Educational research and development into e-learning mainly focuses on the inclusion of new technological features without taking into account psycho-pedagogical concerns that are likely to improve a learner's cognitive process in this new educational category.
Fernando Alonso, Genoveva López, Daniel Manrique, José María Viñes   +3 more
openaire   +2 more sources

Report of the Results of an IMS LEarning Design Expert Workshop [PDF]

, 2009
Neumann, S., Klebl, M., Griffiths, D., Hernández-Leo, D., de la Fuente Valentín, L., Hummel, H., Brouns, F., Derntl, M., & Oberhuemer, P. (2010). Report of the Results of an IMS Learning Design Expert Workshop.
Klebl, M., De la Fuente-Valentin, Luis, Brouns, Francis, Oberhuemer, P., Neumann, S., Brouns, Francis; id_orcid, Hernández-Leo, Davinia, Griffiths Jenkins, David, Neumann, Susanne, Griffiths, David, Neumann, Stella, Hummel, Hans, de la Fuente, Valentin L., Griffiths, Dai, Derntl, Michael, Oberhuemer, Petra, Brouns, F., Hummel, H., Klebl, Michael, De la Fuente Valentín, Luis, Hernández Leo, Davinia   +20 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Esther: person centred integrated system change

International Journal of Integrated Care, 2019
Title: The Design and Learning Centre for Clinical and Social Innovation ( DLC)  is “Making out-of-hospital care safer and more integrated for both citizens( ESTHERs)  and the professionals” and transforming the health and social care system through a ...
Anne Tidmarsh, Robert Stewart
doaj   +1 more source