Results 61 to 70 of about 4,901,852 (302)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
The Wabash Center Journal on Teaching, 2020 In this learning design, the book of Ruth is read closely and critically in order to foster dialogue about political issues in the classroom. Using bell hooks’ model of engaged pedagogy, political issues such as feminism, immigration, gender, sex, and consent are carefully addressed through the pedagogical strategies described.
openaire +3 more sources
Computers in Human Behavior ReportsAdaptive learning environments (ALE) provide great potential for personalizing and supporting learning processes in continuing education (CE). However, valid frameworks for designing ALE for CE have been missing so far.
Yvonne M. Fromm, Dirk Ifenthaler
doaj +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Learning Technologies in Support of Self-Directed Learning
Journal of Interactive Media in Education, 1998 Self-directed learning is a continuous engagement in acquiring, applying and creating knowledge and skills in the context of an individual learner's unique problems.
Gerhard Fischer, Eric Scharff
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Nature Communications, 2023 Intraseasonal variation of rainfall extremes within boreal summer in the Indo-Pacific region is driven by the Boreal Summer Intraseasonal Oscillation (BSISO), a quasi-periodic north-eastward movement of convective precipitation from the Indian Ocean to ...
Felix M. Strnad +4 more
doaj +1 more source
Learning Design – creative design to visualise learning activities [PDF]
Open Learning: The Journal of Open, Distance and e-Learning, 2016 AbstractThe focus on quality improvements by institutions for better online and blended teaching can be delivered in different ways. This article reports on the implementation of this process and the approaches taken first, in terms of the design of new learning materials, and second, when reviewing the existing curriculum.
Lisette Toetenel, Bart Rienties
openaire +1 more source
TypeForming: the Evolution of Typefaces [PDF]
, 2015 An international panel of type and design experts gathered at Sheridan on September 21, 2015 to talk about the form of typography and how its history contributes to its future.
Sheridan Faculty of Animation, Arts & Design +1 more
core +1 more source
Prototype system for supporting the incremental modelling of vague geometric configurations [PDF]
, 1997 In this paper the need for Intelligent Computer Aided Design (Int.CAD) to jointly support design and learning assistance is introduced. The paper focuses on presenting and exploring the possibility of realizing learning assistance in Int.CAD by ...
Duffy, A.H.B., Guan, X., MacCallum, K.J.
core +1 more source