Results 71 to 80 of about 2,043,579 (311)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

The big picture: mining the student data resource to inform learning development provision

Journal of Learning Development in Higher Education, 2017
Accurately assessing student needs is a key concern for learning developers in order for provision to have a strong evidence base. Studies investigating student study needs in higher education tend to provide a snapshot in time and are limited to a ...
Elizabeth Tanguay, Peter Hanratty
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Exploring Ghanaian medical students’ learning experiences during the COVID-19 lockdown: a case study of the University for Development Studies Medical School [version 2; peer review: 2 approved, 1 approved with reservations]

F1000Research
Background The COVID-19 pandemic has had a profound impact on health professions education, particularly in developing and middle-income countries. Despite the implementation of alternative educational strategies to facilitate remote learning while ...
Victor Mogre, Sophia Ewuenye Adwoa Kpebu, Bruce Ayabilla Abugri, Anthony Amalba, Bright Yammaha Amoore   +4 more
doaj   +1 more source

Maximising the benefits associated with internship learning for undergraduates

Journal of Learning Development in Higher Education, 2017
This paper focuses on student responses to an internship programme at an American university in London, with the purpose of highlighting potential areas for curricular improvement.
Christine Fanthome
doaj   +1 more source

Developing Learning Together - Learning Development Networks and LearnHigher

Journal of Learning Development in Higher Education, 1969
This article reflects on the potential of communities and networks, and on the relationship between the Learning Development in Higher Education Network (LDHEN), the Association for Learning Development in Higher Education (ALDinHE) and the LearnHigher CETL.
openaire   +3 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Triangulating Multi-Method Assessments of Parental Support for Early Math Skills

Frontiers in Education, 2020
Past research has examined parental support for math during early childhood using parent-report surveys and observational measures of math talk. However, since most studies only present findings from one of these methods, the construct (parental support ...
Heather J. Bachman, Leanne Elliott, Shirley Duong, Laura Betancur, Monica G. Navarro, Elizabeth Votruba-Drzal, Melissa Libertus   +6 more
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

A Loss Cycle of Burnout Symptoms and Reduced Coping Self-Efficacy: A Latent Change Score Modelling Approach

Chronic Stress
Police officers are frequently faced with chronic and acute stressors, such as excessive workload, organizational stressors and emotionally charged reports.
Liselotte M.J. Koning-Eikenhout, Roos Delahaij, Wim Kamphuis, Inge L. Hulshof, Joris Van Ruysseveldt   +4 more
doaj   +1 more source