Results 51 to 60 of about 385,595 (263)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Influence of narrative settings on learning success in virtual reality games – a case study with “Bridge of Knowledge VR”

Frontiers in Virtual Reality
Gamification has received increasing attention in research and practice. Although narrations as gamification design elements are frequently implemented into gamified systems, specific content- and context-related design elements of narrations are only ...
Katharina Jahn, Markus Suren, Christina Sanchez-Stockhammer, Günter Daniel Rey   +3 more
doaj   +1 more source

Contextualised Media for Learning.

J. Educ. Technol. Soc., 2008
This paper motivates contextualized media for learning and starts with a reference model for describing and analysing contextualized media applications for learning. Based on a more detailed analysis of the context dimension and contextual parameters taken into account when supporting mobile and ubiquitous learning a technical framework and its ...
De Jong, Tim, Specht, Marcus, Koper, Rob
openaire   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Teachers Co-Designing and Enacting Elementary Data Science Curriculum through Connected Learning

Journal of Statistics and Data Science Education
We detail a research-practice partnership between an elementary school and educational researchers with a common goal of increasing data science literacy among rural elementary students. Drawing on connected learning theory and using the CT-STEM taxonomy
Danielle Herro, Ibrahim Oluwajoba Adisa, Oluwadara Abimbade   +2 more
doaj   +1 more source

Reflections on migratory and mobility patterns and labour market security of Ghanaian youth amidst the Covid-19 crisis

Social Sciences and Humanities Open, 2023
This article examines the changing migratory and mobility patterns of Ghanaian youth during the covid-19 pandemic using mixed methods research design. The study reveals that the patterns of migration, mobility and labor market security of the Ghanaian ...
Abdul Latif Anas, Mashudu Salifu, Muhammed Abdulai   +2 more
doaj   +1 more source

Evaluating E-Learning as a Learning Media: A Case of Entrepreneurship E-Learning Using Schoology as Media

International Journal of Emerging Technologies in Learning (iJET), 2018
This study aimed to describe and identify the effectiveness of e-learning strategy on entrepreneurship class at economic education program of STKIP PGRI Jombang. It is an evaluation study using discrepancy evaluation method. The data was from questionnaires and observation, and it would be analyzed descriptively.
Ninik Sudarwati, Rukminigsih
openaire   +2 more sources

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Peer learning in social media enhanced learning environment

Proceedings of the 2012 IEEE Global Engineering Education Conference (EDUCON), 2012
TUT Circle, a dedicated social media service for students at Tampere University of Technology (TUT), was used as a learning environment for the purpose of enhancing studentsâ?? collaboration, communication and networking skills required in business and working life and for promoting peer learning in small groups.
Anne-Maritta Tervakari, Kirsi Silius, Teemo Tebest, Jarno Marttila, Meri Kailanto, Jukka Huhtamäki   +5 more
openaire   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source