Results 51 to 60 of about 3,085,529 (310)

Finely integrated media for language learning [PDF]

, 1993
FLUENT, an immersive foreign‐language learning environment, was developed without recourse to hypermedia techniques. Nevertheless, if one accepts the premisses, proposed in this paper, on which the idea of hypermedia has been constructed, FLUENT shows a ...
Hamburger, Henry
core   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Teachers Co-Designing and Enacting Elementary Data Science Curriculum through Connected Learning

Journal of Statistics and Data Science Education
We detail a research-practice partnership between an elementary school and educational researchers with a common goal of increasing data science literacy among rural elementary students. Drawing on connected learning theory and using the CT-STEM taxonomy
Danielle Herro, Ibrahim Oluwajoba Adisa, Oluwadara Abimbade   +2 more
doaj   +1 more source

Reflections on migratory and mobility patterns and labour market security of Ghanaian youth amidst the Covid-19 crisis

Social Sciences and Humanities Open, 2023
This article examines the changing migratory and mobility patterns of Ghanaian youth during the covid-19 pandemic using mixed methods research design. The study reveals that the patterns of migration, mobility and labor market security of the Ghanaian ...
Abdul Latif Anas, Mashudu Salifu, Muhammed Abdulai   +2 more
doaj   +1 more source

INTERACTIVE MULTIMEDIA BASED LEARNING MEDIA FOR JAVANESE LETTERS USING MACROMEDIA FLASH 8 [PDF]

, 2011
Nowadays the progress of computer technology is rapidly increasing, and with these technologies will allow us to obtain information about cultural heritage, one of which is Javanese letters. Many people find it difficult in learning the Javanese letters.
Marfuatun Nafi' , Khusnul Lutfi
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Influence of narrative settings on learning success in virtual reality games – a case study with “Bridge of Knowledge VR”

Frontiers in Virtual Reality
Gamification has received increasing attention in research and practice. Although narrations as gamification design elements are frequently implemented into gamified systems, specific content- and context-related design elements of narrations are only ...
Katharina Jahn, Markus Suren, Christina Sanchez-Stockhammer, Günter Daniel Rey   +3 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source