Results 191 to 200 of about 3,835,626 (331)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Augmenting pH Confers to <i>Citrus grandis</i> the Ability to Combat Oxidative Stress Triggered by Manganese Excess. [PDF]

Plants (Basel)
Rao RY, Lu F, Lan BB, Zhu X, Huang WL, Chen XF, Lai NW, Yang LT, Guo J, Chen LS.   +9 more
europepmc   +1 more source

Studies on the resistance of melon cultivars to cucumber mosaic virus. (I). Virus multiplication in leaves or mesophyll protoplasts from a susceptible and a resistant cultivars.

, 1989
Satomi HIRAI, Yoshimiki Amemiya
openalex   +2 more sources

Methane potential from household garden leaves

, 2021
Vilis Dubrovskis, Imants Plūme
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Combined polyphenols in Psidium guajava-citrus limon leaf extract attenuate fructose-induced cardiac injury by modulating metabolic and oxidative stress pathways in rats. [PDF]

PLoS One
Essa HA, ElMosbah DE, Fahmy HA.
europepmc   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Response of characteristic hormones in tea roots and leaves under magnesium regulation and their balancing regulation on growth and quality. [PDF]

Front Plant Sci
Jia X, Wang Y, Wang T, Zhu B, Weng Q, Liao Y, Gu J, Luo Y, Zhang Q, Ye J, Wang H.   +10 more
europepmc   +1 more source

EVALUATION OF ANTI-HYPERLIPIDEMIC ACTIVITY OF LEAVES OF IXORA CHINENSIS IN ALBINO RATS

, 2022
Madhurima Yadav Rokalman Sireesha
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source