Results 191 to 200 of about 1,489,525 (342)

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Assessment of the bioactive compounds in gamma irradiated stevia (Stevia rebaudiana Bertoni) leaves. [PDF]

BMC Biotechnol
Eliwa NE, Ahmed MF.
europepmc   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Stinging Trichome Density and Morphology of Three Nettle Species Reflect Mountain Gorillas' Feeding Behavior. [PDF]

Ecol Evol
Nyandwi A, Eckardt W, Bizuru E, Mujawamariya M, DeVore ML.   +4 more
europepmc   +1 more source

The formation of nitrites from nitrates in aqueous solution by the action of sunlight, and the assimilation of the nitrites by green leaves in sunlight

, 1918
Benjamin Moore
openalex   +1 more source

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

Molecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source

Phytochemical characterization of ethanolic and ethyl acetate extracts of avocado Persea americana leaves by FT-IR and GC-MS reveals potential bioactive compounds. [PDF]

Sci Rep
Agunloye MO, Owu DU, Onaadepo O, Ugwu FN, Ogunyemi OM.   +4 more
europepmc   +1 more source

Enzymic Activities of Sub-Cellular Particles from Leaves II. Centrifugal Fractionation and Characterization of Particles in Homogenates of Etiolated Pea Leaves [PDF]

, 1956
RM Smillie
openalex   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Physiological and Multi-Omics Analysis in Leaves of <i>Solanum americanum</i> in Response to Cd Toxicity. [PDF]

Plants (Basel)
Zhou J, Zhu JG, Xiao P, Wang KL, Xu Q, Wu MX, Pan YZ.   +6 more
europepmc   +1 more source