Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
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Phytochemical Profiles and Antimicrobial Activity of <i>Alnus glutinosa</i> (L.) Gaertn. Leaves Growing in Kazakhstan. [PDF]
Bazargaliyeva A +9 more
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This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
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Spectrophotometric Estimation of Polyphenolic Compounds in Willowherbs (<i>Epilobium angustifolium</i> L. and <i>E. hirsutum</i> L.) and Implications for Genetic Resource Conservation. [PDF]
Labokas J, Vilutytė A.
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MiR‐513a promotes human erythroid differentiation by modulating c‐Jun
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim +11 more
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The <i>Ralstonia solanacearum</i> Effector RipP1 Interacts with <i>Nicotiana benthamiana</i> FRL4a to Suppress Ethylene Signaling and Modulate Bacterial Wilt Susceptibility. [PDF]
Xie X +9 more
europepmc +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
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Unveiling the antifungal potential of extracts in leaves and branches from Nicotiana glauca for wood biofungicides. [PDF]
Salem MZM +6 more
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5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
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