The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis
Advanced Science, EarlyView.This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen +6 more
wiley +1 more source
Activation of the Lectin Complement Pathway by H-Ficolin (Hakata Antigen) [PDF]
, 2002 Misao Matsushita +5 more
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Advanced Science, EarlyView.This study demonstrates that Akkermansia muciniphila alleviates colitis by enhancing intestinal α1,2‐fucosylation through its metabolite N‐acetylspermidine. Mechanistically, N‐acetylspermidine‐induced PIM1 inhibition promotes HDAC2‐mediated reduction of chromatin accessibility at TP73, thereby upregulating C1GALT1C1 to boost α1,2‐fucosylation.
Ye Yao +10 more
wiley +1 more source
Glomerular C4d Staining Does Not Exclude a C3 Glomerulopathy
Kidney International Reports, 2019 Introduction: C4d, an early product in the classical/lectin complement pathway has shown potential in the evaluation of C3 glomerulopathy where its absence would support an alternative pathway abnormality.
Geetika Singh +11 more
doaj
Binding of Human Immunodeficiency Virus Type 1 to Immature Dendritic Cells Can Occur Independently of DC-SIGN and Mannose Binding C-Type Lectin Receptors via a Cholesterol-Dependent Pathway [PDF]
, 2003 Suryaram Gummuluru +3 more
openalex +1 more source
Advanced Science, EarlyView.Naturally derived biomembrane nanostructures by mimicking evolutionarily optimized biological architectures could effectively suppress tumor growth and have emerged as a compelling strategy in translational biomedicine. This review provides a systematic overview of rational design and underlying antitumor therapeutic mechanisms of mammalian cells ...
Xiaodan Wei +10 more
wiley +1 more source
L-Ficolin Specifically Binds to Lipoteichoic Acid, a Cell Wall Constituent of Gram-Positive Bacteria, and Activates the Lectin Pathway of Complement [PDF]
, 2004 Nicholas J. Lynch +8 more
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Mannose-binding lectin binds IgM to activate the lectin complement pathway in vitro and in vivo
Immunobiology, 2006 Recent evidence has implicated a role for the MBL-dependent lectin pathway in gastrointestinal and myocardial ischemia/reperfusion (I/R)-induced injury. However, previous studies have implicated IgM and the classical pathway as initiators of complement activation following I/R. Thus, we investigated the potential interaction between MBL and IgM leading
Kazue Takahashi +5 more
openaire +4 more sources
Novel Swelling‐Lytic Cell Death Triggered by Cargo‐Free Ionizable Lipid Nanoparticles
Advanced Science, EarlyView.A cargo‐free ionizable lipid nanoparticles (ipLNP) is found to induce broad swelling‐lytic cell death across multiple cell types. Cell death may be associated with lysosome membrane destabilization, involving ROS increase, lipid peroxidation, and GSDME cleavage.
Junjun Wu +13 more
wiley +1 more source
Human Mannose-binding Lectin and l-Ficolin Function as Specific Pattern Recognition Proteins in the Lectin Activation Pathway of Complement [PDF]
, 2004 Young Gerl +6 more
openalex +1 more source