International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Allergic rhinitis (AR) and asthma are involved in complex interactions between Th1 and Th2 inflammatory pathways. House dust mite (HDM) activates protease‐activated receptor 2 (PAR2) to trigger inflammatory responses, but current treatments often provide inadequate control.
Miran Kang +8 more
wiley +1 more source
Complement-Mediated Neutralization of Dengue Virus Requires Mannose-Binding Lectin
mBio, 2011 Mannose-binding lectin (MBL) is a key soluble pathogen recognition protein of the innate immune system that binds specific mannose-containing glycans on the surfaces of microbial agents and initiates complement activation via the lectin pathway.
Panisadee Avirutnan +5 more
doaj +1 more source
MASP-3 and Its Association with Distinct Complexes of the Mannan-Binding Lectin Complement Activation Pathway [PDF]
, 2001 Mads Ronald Dahl +7 more
openalex +1 more source
Advanced NanoBiomed Research, EarlyView.Overview of the use of silica nanoparticles in vaccines against pathogens. Different kinds of vaccines against infectious diseases are currently using solid or mesoporous silica nanoparticles in their formulation. Silica microparticles and nanoparticles (SiNPs) have been studied as vehicles for vaccines.
Noe Juvenal Mendoza‐Ramírez +3 more
wiley +1 more source
Activation of the Lectin Complement Pathway by H-Ficolin (Hakata Antigen) [PDF]
, 2002 Misao Matsushita +5 more
openalex +1 more source
Serine Proteases in the Lectin Pathway of the Complement System [PDF]
Proteases in Physiology and Pathology, 2017 The complement system plays a crucial role in host defense against pathogen infections and in the recognition and removal of damaged or altered self-components. Complement system activation can be initiated by three different pathways—classical, alternative, and lectin pathways—resulting in a proteolytic cascade, which culminates in multiple biological
Andrade F +3 more
europepmc +3 more sources
Binding of Human Immunodeficiency Virus Type 1 to Immature Dendritic Cells Can Occur Independently of DC-SIGN and Mannose Binding C-Type Lectin Receptors via a Cholesterol-Dependent Pathway [PDF]
, 2003 Suryaram Gummuluru +3 more
openalex +1 more source
Harnessing chimeric antigen receptor macrophages against solid tumors
Cancer Communications, EarlyView.Abstract Macrophages are prevalent in multiple tumors and exhibit diverse and potent functional activities. Therapeutic reprogramming of macrophage phenotypes represents a promising strategy for cancer immunotherapy. Engineering chimeric antigen receptors (CARs) to endow macrophages with anti‐tumor capacities demonstrated encouraging efficacy ...
Mengru Wang +3 more
wiley +1 more source
Frontiers in Immunology, 2019 Platelets play an essential role in maintaining homeostasis in the circulatory system after an injury by forming a platelet thrombus, but they also occupy a central node in the intravascular innate immune system.
Oskar Eriksson +4 more
doaj +1 more source
Human Mannose-binding Lectin and l-Ficolin Function as Specific Pattern Recognition Proteins in the Lectin Activation Pathway of Complement [PDF]
, 2004 Young Gerl +6 more
openalex +1 more source