Results 131 to 140 of about 2,513,226 (377)
Advanced Materials, EarlyView.A novel hydrogen bond re‐orientation (HyBRO) strategy enables three‐dimensional (3D) printing of vascular microchannel networks with high accuracy. By switching sacrificial material interactions with nonsolvents, HyBRO prevents swelling and deformation, enabling accurate hierarchical channels spanning a tenfold size range.
Zhencheng Liao +5 more
wiley +1 more source
Protein‐Like Polymers Targeting Keap1/Nrf2 as Therapeutics for Myocardial Infarction
Advanced Materials, EarlyView.We describe a Keap1 targeting protein‐like polymer (PLP) which activates Nrf2, an important cytoprotective transcription factor for relieving myocardial infarction‐induced oxidative stress. This PLP increases cell survival in vitro in multiple relevant cardiac cell types and elicits pro‐reparative responses, improving cardiac function in a preclinical ...
Joshua M. Mesfin +17 more
wiley +1 more source
Lectin Pathway Components And Its Transfer From Blood To Cerebrospinal Fluid
Revista Cubana de Investigaciones Biomédicas, 2019 Introduction: Defining mechanisms governing the diffusion from blood to cerebrospinal fluid is central to understanding immune function in the central nervous system. OBJECTIVE.
Alejandro Ramos-Robledo +5 more
doaj
Absence of the Lectin Activation Pathway of Complement Ameliorates Proteinuria-Induced Renal Injury
Frontiers in Immunology, 2019 Proteinuria is an adverse prognostic feature in renal diseases. In proteinuric nephropathies, filtered proteins exert an injurious effect on the renal tubulointerstitium, resulting in inflammation and fibrosis.
Samy Alghadban +8 more
doaj +1 more source
Confirmation that T cell receptor activation is digital, not analog. Hence individual T cell cytolytic capacity is independent of initial stimulation strength [PDF]
arXiv, 2018 Whether a sub-optimum lymphocyte stimulus is achieved by lowering ligand concentration, or decreasing its affinity, initial TCR activation responses are likely to be digital. We now know for cultured peripheral blood mononuclear cells (PBMCs), when activated by plant lectins such as concanavalin-A (Con-A), that the responding cells are T cells, and ...
arxiv
Seizure pathways and seizure durations can vary independently within individual patients with focal epilepsy [PDF]
arXiv, 2021 A seizure's electrographic dynamics are characterised by its spatiotemporal evolution, also termed dynamical "pathway" and the time it takes to complete that pathway, which results in the seizure's duration. Both seizure pathways and durations can vary within the same patient, producing seizures with different dynamics, severity, and clinical ...
arxiv
Regulation of eosinophilia and allergic airway inflammation by the glycan-binding protein galectin-1 [PDF]
, 2016 Galectin-1 (Gal-1), a glycan-binding protein with broad antiinflammatory activities, functions as a proresolving mediator in autoimmune and chronic inflammatory disorders. However, its role in allergic airway inflammation has not yet been elucidated.
Abramoff +15 more
core +1 more source
Journal of Clinical Investigation, 2020 Primary membranous nephropathy (pMN) is a leading cause of the nephrotic syndrome in adults. In most cases, this autoimmune kidney disease is associated with autoantibodies against the M-type phospholipase A2 receptor (PLA2R1) expressed on kidney ...
G. Haddad +17 more
semanticscholar +1 more source
Microbiome Single Cell Atlases Generated with a Commercial Instrument
Advanced Science, EarlyView.Single cell sequencing is valuable for dissecting complex systems and uncovering unique features in individual cell types. However, tools for single cell microbial analysis are limited. Easily Accessible Single microbe sequencing (EASi‐seq), which adapts a commercially available single cell platform for efficient sequencing of single microbial genomes ...
Xiangpeng Li +8 more
wiley +1 more source
Toward a structure-based comprehension of the lectin pathway of complement [PDF]
Molecular Immunology, 2013 To initiate the lectin pathway of complement pattern recognition molecules bind to surface-linked carbohydrates or acetyl groups on pathogens or damaged self-tissue. This leads to activation of the serine proteases MASP-1 and MASP-2 resulting in deposition of C4 on the activator and assembly of the C3 convertase.
Kjaer, Troels Rønn +2 more
openaire +5 more sources