European Journal of Heart Failure, EarlyView.The analysis workflow, findings and potential clinical consequences of iron deficiency in heart failure (HF). From 881 patients with worsening HF, whole blood transcriptome was analysed using the Affymetrix Human Transcriptome Array (HTA) 2.0. Subjects were stratified according to their transferrin saturation (TSAT) levels as iron‐deficient (TSAT <20%)
Niels Grote Beverborg +17 more
wiley +1 more source
Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation. [PDF]
J Biol Chem, 2022 Nagy ZA +12 more
europepmc +1 more source
The lectin concanavalin‐A signals MT1‐MMP catalytic independent induction of COX‐2 through an IKKγ/NF‐κB‐dependent pathway [PDF]
, 2010 Asmaa Sina +5 more
openalex +1 more source
Natural inhibitors of the lectin pathway
Immunobiology, 2012 Péter Závodszky +3 more
openaire +2 more sources
Expanding the Chemical Space of Sugar Frameworks by Quaternization of the Anomeric Carbon Atom
European Journal of Organic Chemistry, EarlyView.Novel C,C and C,N bifunctional fucosides are stereoselectively obtained starting from a common anomeric bromide intermediate. The developed methodology expands the chemical space at the anomeric position of fucose and supports future applications in glycomimetics design.
Sarah Mazzotta +5 more
wiley +1 more source
Association Of Mannose Binding Lectin (MBL) Gene Mutations With Other Pathway Defects Spanning Innate And Adaptive Immune Responses [PDF]
, 2011 M.B. Pate +3 more
openalex +1 more source
Targeting the Tumor Microbiota in Cancer Therapy Basing on Nanomaterials
Exploration, EarlyView.Intra‐tumoral microbiota, which is a potential component of the tumor microenvironment, has been emerging as a key participant and driving factor in cancer. This article reviews the latest progress in this field, including the microbial community within tumors and its pro‐cancer mechanisms, as well as the anti‐tumor strategies targeting intra‐tumoral ...
Yanan Niu +4 more
wiley +1 more source
Directed Evolution-Driven Increase of Structural Plasticity Is a Prerequisite for Binding the Complement Lectin Pathway Blocking MASP-Inhibitor Peptides. [PDF]
ACS Chem Biol, 2022 Dürvanger Z +14 more
europepmc +1 more source
The role of the lectin VIP36 in the early secretory pathway
, 2010 Lectins are of emerging importance for quality control and intracellular transport of glycoproteins in mammalian cells. One of the most prominent lectins involved in intracellular transport is ERGIC-53, which belongs to the family of L-type lectins. ERGIC-53 mediates the ER export of several glycoproteins like cathepsin Z, α1-antitrypsin (α1-AT) or ...
openaire +3 more sources
Food Frontiers, EarlyView.Two water‐soluble polysaccharides were isolated and purified from Tricholoma flavovirens (TF‐P) and Trametes versicolor (TV‐P), respectively. The structures of the two polysaccharides were identified by combining GPC, FT‐IR, HPLC, GC–MS, and NMR, and the structure–activity relationship has also been studied using immune cells and tumor cells. TV‐P with
Zheng‐Ao Sun +5 more
wiley +1 more source