Results 221 to 230 of about 103,608 (291)

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source

S1685 Oligosaccharide Alterations in IgG in Inflammatory Bowel Disease Is Not Associated with MBL Lectin Complement Pathway But with Enhancement of Antibody-Dependent Phagocytosis

, 2009
Hideki Iijima, Sachiko Nakajima, Shinichiro Shinzaki, Satoshi Egawa, Takahiro Inoue, Yoshito Hayashi, Jumpei Kondo, Shuji Ishii, Toshiyuki Yoshio, Tsutomu Nishida, Tatsuya Kanto, Eiji Miyoshi, Masahiko Tsujii, Norio Hayashi   +13 more
openalex   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

Thiol isomerase ERp57 targets and modulates the lectin pathway of complement activation. [PDF]

J Biol Chem, 2019
Eriksson O, Chiu J, Hogg PJ, Atkinson JP, Liszewski MK, Flaumenhaft R, Furie B.   +6 more
europepmc   +1 more source

Comparative Transcriptomic Analysis of Human Macrophages During Mycobacterium avium Versus Mycobacterium tuberculosis Infection

Molecular Microbiology, EarlyView.
Human macrophage transcriptomic responses to Mycobacterium avium (Mav), a major cause of nontuberculous lung disease, were compared to Mycobacterium tuberculosis (Mtb). Both infections activated overlapping immune pathways, including cytokine signaling and GPCRs involved in lipid metabolism, while phospholipases were more strongly regulated by Mav and ...
Gül Kilinç, Robin H. G. A. van den Biggelaar, Tom H. M. Ottenhoff, Leon H. Mei, Anno Saris   +4 more
wiley   +1 more source

The maize mitogen‐activated protein kinase kinase kinase gene ZmMAPKKK45 is associated with multiple disease resistance

New Phytologist, EarlyView.
Summary Southern leaf blight (SLB), caused by the necrotrophic fungus Cochliobolus heterostrophus, is a major foliar disease of maize (Zea mays) world‐wide. A genome‐wide association study was performed to dissect the genetic basis of SLB resistance in maize. Functional validation was performed using mutant and transgenic analyses.
Tao Zhong, Bode Olukolu, Yang Bian, Shang Xue, Randall J. Wisser, Peter S. Ojiambo, James B. Holland, Qin Yang, Peter Balint‐Kurti   +8 more
wiley   +1 more source

From bacterial predators to partners: phages in agriculture

New Phytologist, EarlyView.
Summary Bacteriophages, viruses that infect bacteria, are critical players for shaping the taxonomic and functional composition of plant‐associated microbiomes. Yet, their roles in plant health remain overlooked, along with their implications for sustainable agriculture.
Zahra Salehimoghaddam, Alexander P. Hynes, Rebecca T. Doyle   +2 more
wiley   +1 more source