Results 281 to 290 of about 159,204 (339)

Editorial: Community series in the role of complement in health and disease, volume II

Frontiers in Immunology
Maciej Cedzyński, Thomas Vorup-Jensen, Thomas Vorup-Jensen, Marcin Okrój, Anna S. Świerzko   +4 more
doaj   +1 more source

The Evolutionary Dynamics of Genetic Mutational Load Throughout Tomato Domestication History

Molecular Ecology, EarlyView.
ABSTRACT Understanding the impact of domestication on deleterious mutations has fascinated evolutionary biologists and breeders alike. A ‘cost of domestication’ has been reported for some organisms through accumulation of gene disruptions or radical amino acid changes.
Hamid Razifard, Sofia Visa, Naama Menda, Lukas Mueller, Denise Tieman, Esther van der Knaap, Ana L. Caicedo   +6 more
wiley   +1 more source

Zymoseptoria tritici stealth infection is facilitated by stage‐specific downregulation of a β‐glucanase

New Phytologist, EarlyView.
Summary Plant cell walls constitute a major defence barrier against pathogens, although it is unclear how specific cell wall components impact pathogen colonisation. Pathogens secrete cell wall‐degrading enzymes (CWDEs) to facilitate plant colonisation, but damaged or infected cells are often a source of cell wall‐derived oligosaccharides that trigger ...
Diego Rebaque, Cristian Carrasco‐López, Parvathy Krishnan, Gemma López, Sergio López‐Cobos, Felipe de Salas, Lukas Meile, Cécile Lorrain, Asier Largo‐Gosens, Bruce A. McDonald, Francisco Vilaplana, María Jesús Martínez, Hugo Mélida, Antonio Molina, Andrea Sánchez‐Vallet   +14 more
wiley   +1 more source

Porphyromonas gingivalis GroEL exacerbates orthotopic allograft transplantation vasculopathy via impairment of endothelial cell function

Molecular Oral Microbiology, EarlyView.
Abstract Orthotopic allograft transplantation (OAT) is a significant approach to addressing organ failure. However, persistent immune responses to the allograft affect chronic rejection, which induces OAT vasculopathy (OATV) and organ failure. Porphyromonas gingivalis can infiltrate remote organs via the bloodstream, thereby intensifying the severity ...
Chien‐Sung Tsai, Chun‐Yao Huang, Yi‐Ting Tsai, Chun‐Ming Shih, Ze‐Hao Lai, Chen‐Wei Liu, Yi‐Wen Lin, Feng‐Yen Lin   +7 more
wiley   +1 more source

Molecular changes in agroinfiltrated leaves of Nicotiana benthamiana expressing suppressor of silencing P19 and coronavirus‐like particles

Plant Biotechnology Journal, EarlyView.
Summary The production of coronavirus disease 2019 vaccines can be achieved by transient expression of the spike (S) protein of severe acute respiratory syndrome coronavirus 2 in agroinfiltrated leaves of Nicotiana benthamiana. Relying on bacterial vector Agrobacterium tumefaciens, this process is favoured by co‐expression of viral silencing suppressor
Louis‐Philippe Hamel, Francis Poirier‐Gravel, Marie‐Ève Paré, Rachel Tardif, Marc‐André Comeau, Pierre‐Olivier Lavoie, Andréane Langlois, Marie‐Claire Goulet, Dominique Michaud, Marc‐André D'Aoust   +9 more
wiley   +1 more source

Identification of β‐galactosidases along the secretory pathway of Nicotiana benthamiana that collectively hamper engineering of galactose‐extended glycans on recombinant glycoproteins

Plant Biotechnology Journal, EarlyView.
Summary Glycosylation is an important aspect for many biopharmaceuticals, including vaccines against parasitic helminths. Plants, especially Nicotiana benthamiana, have proven to be excellent production hosts for biopharmaceuticals with tailor‐made glycosylation.
Alex van der Kaaij, Myrna J. M. Bunte, Lisa Nijhof, Sanaz Mokhtari, Hein Overmars, Arjen Schots, Ruud H. P. Wilbers, Pieter Nibbering   +7 more
wiley   +1 more source

Posttranslational modifications of heterologous proteins expressed in Nicotiana benthamiana

Plant Biotechnology Journal, EarlyView.
Summary The success of Nicotiana benthamiana as a workhorse for heterologous protein production is closely linked to its accessibility and tolerance to genetic manipulation, allowing efficient engineering of posttranslational protein modifications (PTMs) that are critical for the function and stability of heterologous proteins.
Kathrin Göritzer, Somanath Kallolimath, Richard Strasser   +2 more
wiley   +1 more source

Analysis of Non‐Coding RNAs and N6‐Methyladenosine‐Modified Genes in Response to flg22 in Grape Immunity

Plant Biotechnology Journal, EarlyView.
ABSTRACT Grape (Vitis vinifera) is susceptible to fungal pathogens and, consequently, severe yield losses. Investigating the immune mechanisms of the disease‐resistant Chinese wild grapes is crucial for developing sustainable disease resistance technologies.
Ruiwei Duan, Yang Feng, Runxin Zhang, Wenjing Lu, Qingqing Xie, Dong Duan   +5 more
wiley   +1 more source

Rice RING E3 Ligase OsRMT1 Negatively Regulates Salt Tolerance by Degrading the Canonical Salt‐Responsive Protein OsMBL1

Plant Biotechnology Journal, EarlyView.
ABSTRACT Excessive salinity is a major non‐biological stressor that hinders plant development and reduces agricultural productivity. In rice, a jacalin‐related mannose‐binding lectin (OsMBL1) is known to be a canonical salt‐responsive factor, but its biological function and regulatory mechanism in response to salt stress remain unclear.
Wenjuan Zhang, Kun Jing, Jun Zhu, Jingyu Shen, Jinjin Jiang, Cailin Ge, Haidong Ding, Youping Wang   +7 more
wiley   +1 more source

CRISPR/Cas9‐Mediated Knockouts of the ALG3 and GNTI in N. benthamiana and Their Application to Pharmaceutical Production

Plant Biotechnology Journal, EarlyView.
ABSTRACT N‐Glycosylation critically influences the efficacy, safety and pharmacokinetic properties of biopharmaceuticals. Plant expression platforms offer multiple advantages for the production of N‐glycosylated proteins, but their use is impeded by the presence of plant‐specific N‐glycan epitopes, which raise concerns of possible immunogenicity to ...
Dolgormaa Bataa, Hiroyuki Kajiura, Reimi Lai Sang Sawada‐Choi, Yukino Yamashita, Takeshi Ishimizu, Ryo Misaki, Atsushi Takeda, Kazuhito Fujiyama   +7 more
wiley   +1 more source