Results 271 to 280 of about 3,190,451 (315)

Inhibition of the Lectin Pathway of the Complement System as a Novel Approach in the Management of IgA Vasculitis-Associated Nephritis

Nephron, 2020
IgA vasculitis can present as a glomerulonephritis histologically indistinguishable from IgA nephropathy (IgAN). In IgAN, the alternative and lectin pathways mediate glomerular injury and contribute to kidney function decline. Narsoplimab is a monoclonal
H. Selvaskandan, Chee Kay Cheung, J. Dormer, David H. Wimbury, Maria Martinez, Gang Xu, Jonathan Barratt   +6 more
semanticscholar   +1 more source

Assays for the Mannan‐Binding Lectin Pathway

Current Protocols in Immunology, 2003
AbstractThis unit contains protocols that can be used to measure mannan‐binding lectin (MBL) levels and MBL pathway activity in human plasma or serum. Using a modification of the conventional ELISA, the detection reagent used in the methods described (e.g., an antibody or streptavidin) is labeled with Eu3+ instead of an enzyme.
Gadjeva, Mihaela, Thiel, Steffen; id_orcid 0000-0002-4817-155X, Jensenius, Jens Christian   +2 more
openaire   +2 more sources

The Lectin Pathway of Complement and Biocompatibility

2015
In modern health technologies the use of biomaterials in the form of stents, haemodialysis tubes, artificial implants, bypass circuits etc. is rapidly expanding. The exposure of synthetic, foreign surfaces to the blood and tissue of the host, calls for strict biocompatibility in respect to contact activation, the coagulation system and the complement ...
Hein, Estrid, Garred, Peter
openaire   +3 more sources

The Lectin Pathway of the Complement System

Microbiology and Immunology, 1996
One of the activities of animal lectins is the elimination of pathogens from a host. Serum mannose (or mannan)-binding protein (MBP) (25), in this capacity, recognizes mannose or N-acetylglucosamine on the surfaces of microorganisms. MBP is a member of the 'collectin' family (6), a group of C-type Ca2+-denendent animal lectins (3) which includes two ...
openaire   +2 more sources

Derivatives of the lectin complement pathway in Lophotrochozoa

Developmental & Comparative Immunology, 2019
A plethora of non-overlapping immune molecular mechanisms in metazoans is the most puzzling issue in comparative immunobiology. No valid evolutionary retrospective on these mechanisms has been developed. In this study, we aimed to reveal the origin and evolution of the immune complement-like system in Lophotrochozoa.
openaire   +2 more sources

Asparaginase inhibits the lectin pathway of complement activation

Molecular Immunology, 2018
Oncological treatment has been associated with an increased risk of infection, most often related to therapy-induced pancytopenia. However, limited research has been conducted on the effect of oncological therapy on the complement system, being part of the non-cellular innate immune system. This became the rationale for an observational clinical study (
Keizer, M. P., Aarts, C., Kamp, A. M., Caron, H. N., van de Wetering, M. D., Wouters, D., Kuijpers, T. W.   +6 more
openaire   +3 more sources

The role of ficolins in the lectin pathway of innate immunity

The International Journal of Biochemistry & Cell Biology, 2011
Ficolins are a family of oligomeric proteins consisting of an N-terminal collagen-like domain and a C-terminal globular fibrinogen-like domain. They are novel lectins that employ the fibrinogen-like domain as a functional domain. Ficolins specifically recognize N-acetyl compounds such as N-acetylglucosamine, components of bacterial and fungal cell ...
Yuichi, Endo, Misao, Matsushita, Teizo, Fujita   +2 more
openaire   +2 more sources

Activation of the lectin pathway in murine lupus nephritis

Molecular Immunology, 2005
In systemic lupus erythematosus (SLE), hypocomplementaemia and complement deposition have been described both in man and in experimental models. A major involvement of the classical pathway of complement activation has been demonstrated in this disease, however relatively little is known about the involvement of the lectin pathway.
Leendert A, Trouw, Marc A, Seelen, Jacques M G J, Duijs, Sven, Wagner, Michael, Loos, Ingeborg M, Bajema, Cees, van Kooten, Anja, Roos, Mohamed R, Daha   +8 more
openaire   +2 more sources

Relevance of the lectin pathway of complement in rheumatic diseases

2012
Due to its importance both in the clearance of pathogens that contribute as rheumatic etiological agents and in the disposal of apoptotic bodies and potential autoimmune initiators, deficiencies of the components of the lectin pathway of complement have been found to increase susceptibility and modulate the severity of most rheumatic disorders.
Angelica B W, Boldt, Isabela, Goeldner, Iara J T, de Messias-Reason   +2 more
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The lectin pathway in renal disease

Nephrology, Dialysis, Transplantation, 2018
The complement system is composed of a network of at least 40 proteins, which significantly contributes to health and disease. The lectin pathway (LP) is one of three pathways that can activate the complement system. Next to protection of the host against pathogens, the LP has been shown to play a crucial role in multiple renal diseases as well as ...
da Costa, Mariana Gaya, Poppelaars, Felix, Berger, Stefan P., Daha, Mohamed R., Seelen, Marc A.   +4 more
openaire   +1 more source