Results 291 to 300 of about 2,513,226 (377)

Organ Specificity and Commonality of Epigenetic Aging in Low‐ and High‐Running Capacity Rats

open access: yesAging Cell, EarlyView.
Cardiorespiratory fitness (CRF) is not associated with epigenetic clocks, including newly developed ones. On the other hand, CRF is associated with global methylation profiles and promoter methylation in organ‐specific and organ‐common manner. ABSTRACT Epigenetic drift, which is gradual age‐related changes in DNA methylation patterns, plays a ...
Takuji Kawamura   +15 more
wiley   +1 more source

Targeted deletions of complement lectin pathway genes improve outcome in traumatic brain injury, with MASP-2 playing a major role. [PDF]

open access: yesActa Neuropathol Commun, 2020
Mercurio D   +10 more
europepmc   +1 more source

ConBr lectin modulates MAPKs and Akt pathways and triggers autophagic glioma cell death by a mechanism dependent upon caspase-8 activation

open access: bronze, 2020
Ingrid A.V. Wolin   +13 more
openalex   +1 more source

Targeting CA2 Perineuronal Nets Restores Recognition Memory and Theta Oscillations in Aged Mice

open access: yesAging Cell, EarlyView.
Targeting CA2 perineuronal nets restores social/non‐social recognition memory and theta oscillations in aged mice: Aged mice displayed deficits in both social and object recognition memory, which were accompanied by enhanced perineuronal nets (PNNs) density and reduced theta power in the dCA2 region.
Sonam Fathima Mehak   +5 more
wiley   +1 more source

Vaccine‐Induced Anti‐IgE Antibodies Neutralize Free IgE but Fail to Bind and Activate Mast Cell‐Displayed IgE

open access: yesAllergy, EarlyView.
We investigated the mechanisms by which a previously established VLP‐based anti‐IgE vaccine protects against allergic anaphylaxis. We show that passively administered vaccine‐induced IgGs into allergic mice protects them from anaphylaxis without side effects.
Zahra Gharailoo   +3 more
wiley   +1 more source

Gastrointestinal Barrier Disruption in Post‐COVID Syndrome Fatigue Patients

open access: yesAllergy, EarlyView.
Gastrointestinal (GI) barrier disruption in the context of SARS‐CoV‐2 infection is associated with the development of Post‐COVID Syndrome (PCS) Fatigue. Pre‐existing GI complaints may predispose to fatigue development. Monitoring GI symptoms and markers before, during, and after SARS‐CoV‐2 infection is crucial for identifying predictive clinical ...
Johanna Rohrhofer   +8 more
wiley   +1 more source

Effects of Maackia amurensis seed lectin (MASL) on oral squamous cell carcinoma (OSCC) gene expression and transcriptional signaling pathways

open access: green, 2020
Kelly L. Hamilton   +7 more
openalex   +2 more sources

Role for Complement C5 in Eosinophilic Inflammation of Severe Asthma

open access: yesAllergy, EarlyView.
Complement activation module, particularly C5, is positively associated with eosinophilic inflammation in severe asthma cohorts. Elevated C5 expression correlates with poor lung function improvement and persistent eosinophilic inflammation. Mouse model studies confirm that C5 exacerbates eosinophilic inflammation, highlighting its potential as a ...
Cong Dong   +217 more
wiley   +1 more source

Deconstructing the Lectin Pathway in the Pathogenesis of Experimental Inflammatory Arthritis: Essential Role of the Lectin Ficolin B and Mannose-Binding Protein–Associated Serine Protease 2

open access: yesJournal of Immunology, 2017
N. Banda   +11 more
semanticscholar   +1 more source

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