Results 111 to 120 of about 30,035 (192)
FGB1 and WSC3 are in planta-induced beta-glucan-binding fungal lectins with different functions
, 2019 In the root endophyte Serendipita indica, several lectin-like members of the expanded multigene family of WSC proteins are transcriptionally induced in planta and are potentially involved in beta-glucan remodeling at the fungal cell wall.
Becker, S. +8 more
core +1 more source
Clinical Pharmacology &Therapeutics, Volume 118, Issue 1, Page 242-251, July 2025.Although attractive for relevance to real‐world scenarios, real‐world data (RWD) is typically used for drug repurposing and not therapeutic target discovery. Repurposing studies have identified few effective options in neurological diseases such as the rare disease, amyotrophic lateral sclerosis (ALS), which has no disease‐modifying treatments ...
Mohammadali Alidoost +9 more
wiley +1 more source
Genetically enhanced recombinant lectins for glyco-selective analysis and purification [PDF]
, 2011 - Generation of a library of recombinant prokaryotic lectins (RPL’s) through random mutagenesis of the carbohydrate binding sites of bacterial lectins. - Characterisation of mutant lectins with respect to structure and specificity - Provision of mutant
Clarke, Paul A. +5 more
core
Clinical Pharmacology &Therapeutics, EarlyView.Riliprubart is a second‐generation, humanized immunoglobulin G4 that inhibits only the activated form of the C1s component of the proximal classical complement pathway. The clinical studies of riliprubart conducted thus far for the treatment of cold agglutinin disease (CAD), a rare autoimmune disease, include a Phase 1 first‐in‐human study in healthy ...
Timothy Chow +3 more
wiley +1 more source
Glycomimetic Ligands for C-type Lectin Recognition.
, 2023 Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
Luna León, Rubén +1 more
openaire +1 more source
Developmental Dynamics, EarlyView.Abstract Background While heart function is broadly conserved across vertebrates, the cellular phenotype of muscle cells (cardiomyocytes) varies across taxa and throughout ontogeny. Emerging evidence suggests that some attributes may correlate with the capacity for spontaneous cardiomyocyte replacement following injury.
Kathy Jacyniak +4 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1398-1415, April 2025.Abstract Background Cardiac remodelling, a crucial aspect of heart failure, is commonly investigated in preclinical models by quantifying cardiomyocyte cross‐sectional area (CSA) and microvascular density (MVD) via histological methods, such as immunohistochemistry.
Tamás G. Gergely +14 more
wiley +1 more source
The effects of early exercise on cardiovascular biomarkers in patients with congestive heart failure
ESC Heart Failure, EarlyView.Abstract Background Exercise training improves functional outcomes in chronic heart failure (HF), but the effects of early in‐hospital physical activity on cardiovascular biomarkers and prognosis in acute congestive heart failure (AHF) patients remain unclear.
Yanxiang Sun +6 more
wiley +1 more source
ESC Heart Failure, EarlyView.Abstract Aims Most proteomic analyses in patients with heart failure (HF) focus on the stable ambulatory setting; pathways that drive acute decompensated heart failure (ADHF) are largely uncharacterized. We aimed to examine the associations of cardiometabolic proteins with HF rehospitalization, mortality and diuretic response in patients with ADHF ...
Kenneth T. Hubbell +8 more
wiley +1 more source
European Journal of Heart Failure, EarlyView.Markers of progression to heart failure (HF). Gal‐4, galectin‐4; GDF‐15, growth differentiation factor 15; NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide; ST2, suppression of tumorigenicity‐2. ABSTRACT Aims Biomarkers associated with asymptomatic ventricular dysfunction might improve risk stratification and identify pathways leading to heart ...
Anna Dieden +23 more
wiley +1 more source