Results 111 to 120 of about 1,772,176 (315)
Parasites & Vectors, 2014 Background The studies on sialomes have shown that hematophagous mosquito saliva consists of a lot of pharmacologically active proteins, in which C-type lectins have been identified and regarded as an important component of saliva.
Jinzhi Cheng +5 more
doaj +1 more source
ACS Chemical Biology, 2018 Here, we describe a strategy for the rapid preparation of pure positional isomers of complex N-glycans to complement an existing array comprising a larger number of N-glycans and smaller glycan structures.
Begoña Echeverria +8 more
semanticscholar +1 more source
Levels of complexity in pathogen recognition by C-type lectins
Current Opinion in Immunology, 2005 In pathogen recognition by C-type lectins, several levels of complexity can be distinguished; these might modulate the immune response in different ways. Firstly, the pathogen-associated molecular pattern repertoire expressed at the microbial surface determines the interactions with specific receptors.
Cambi, A., Figdor, C.G.
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Advanced Science, EarlyView.ST6GAL1 plays a critical role in tumor progression and immune regulation in colorectal cancer (CRC). Its depletion significantly suppresses the malignant phenotype of CRC cells and enhances the efficacy of anti‐PD‐L1 therapy. High ST6GAL1 expression promotes an immune‐activated tumor microenvironment (TME), characterized by increased infiltration of ...
Ximo Xu +15 more
wiley +1 more source
PLoS Pathogens, 2017 C-type lectins (CTLs) are characterized by the presence of a C-type carbohydrate recognition domain (CTLD) that by recognizing microbial glycans, is responsible for their roles as pattern recognition receptors in the immune response to bacterial ...
Jie-Jie Sun +4 more
semanticscholar +1 more source
Integrin α8‐Mediated Pericyte Morphogenesis Controls Blood‐Brain Barrier Integrity
Advanced Science, EarlyView.This study highlights that ITGA8 impacts pericyte morphology and function, both crucial for BBB integrity, via RhoA/ROCK signaling, thus influencing TGF‐β1 activation through cytoskeletal tension and ECM interactions. Notably, in post‐ischemic recovery models, ITGA8 deficiency exacerbates vascular dysfunction by impairing pericyte‐mediated BBB ...
Chang‐Xiong Gong +16 more
wiley +1 more source
Crotacetin, a novel snake venom C-type lectin, is homolog of convulxin
Journal of Venomous Animals and Toxins including Tropical Diseases, 2005 Snake venom (sv) C-type lectins encompass a group of hemorrhagic toxins, which are able to interfere with hemostasis. They share significant similarity in their primary structures with C-type lectins of other animals, and also present a conserved ...
G. Rádis-Baptista +8 more
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Glycan detecting tools developed from the Clostridium botulinum whole hemagglutinin complex
Scientific Reports, 2021 Lectins are proteins with the ability to recognize and bind to specific glycan structures. These molecules play important roles in many biological systems and are actively being studied because of their ability to detect glycan biomarkers for many ...
Ea Kristine Clarisse Tulin +9 more
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C-type lectins in immunity to Mycobacterium tuberculosis
Frontiers in Bioscience, 2011 Tuberculosis (TB) remains one of the leading causes of death due to a single infectious agent, Mycobacterium tuberculosis, with nearly 2 million deaths per year (1). Most individuals exposed to the bacillus develop a nonpathological form, latent TB, with only a small minority (5 to 10%) developing active disease.
Olivier Neyrolles, Antoine Tanne
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Advanced Science, EarlyView.Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li +13 more
wiley +1 more source