Results 231 to 240 of about 43,176 (288)

The Entomotoxic Fungal Lectin <i>Marasmius oreades</i> Agglutinin Disrupts the Midgut Epithelium of Colorado Potato Beetle Larvae. [PDF]

J Agric Food Chem
Žigon P, Bogataj U, Praček S, Peternel T, Mrak P, Smodiš Škerl MI, Ladányi M, Karničar K, Fonović M, Panevska A, Skočaj M, Turk D, Žnidaršič N, Razinger J, Sabotič J.   +14 more
europepmc   +1 more source

Slit2/Robo Signaling Restores Diabetic Erectile Function via Neurovascular Remodeling

Andrology, EarlyView.
ABSTRACT Background Diabetes mellitus‐induced erectile dysfunction (DMED) is a common and debilitating vascular‐neurogenic complication of diabetes. The poor responsiveness of DMED patients to phosphodiesterase type‐5 inhibitors underscores the need for therapies capable of restoring both endothelial integrity and cavernous nerve function.
Sen Fu, Peng Hu, Zizhong Yang, Zhenghui Jin, Xiaoyu Zhu, Tao Wang, Jihong Liu, Kai Cui   +7 more
wiley   +1 more source

Glycan atlassing enables functional tracing of cell state. [PDF]

Nat Nanotechnol
Moonnukandathil Joseph D, Yurekli N, Fritsche S, Hashem R, Thoma OM, Larafa I, Boric T, Bielawski C, Almahayni K, Franze K, Waldner MJ, Möckl L.   +11 more
europepmc   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Spatial localization of avian and human influenza A virus receptors in male and female bovine reproductive tissues. [PDF]

Sci Rep
Poliakiwski BD, Minela T, Smith DJ, Seekford ZK, Cain JW, Polanco O, Johnson GA, Luense LJ, Ross PJ, Dimitrov KM, Lamb GC, Pohler KG.   +11 more
europepmc   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Identification of aberrant α-2,3 sialylation of cartilage associated with osteonecrosis of the femoral head based on integrated multi-omics analyses. [PDF]

BBA Adv
Lu X, Wang X, Xiong M, Wang P, Zhu Y, Wang X, Liu X, Yu H, Liu R.   +8 more
europepmc   +1 more source

Targeting Yeast Pathogens with Lectins: A Narrative Review from Mechanistic Insights to the Need for Addressing Translational Challenges. [PDF]

Biomedicines
Ferreira GRS, Lira TLDS, Napoleão TH.
europepmc   +1 more source

Garadacimab for the long‐term prophylaxis of hereditary angioedema

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Hereditary angioedema (HAE), a rare and debilitating disease characterized by recurrent and spontaneous attacks of tissue swelling, has a high unmet therapeutic need, with many patients experiencing insufficient disease control with current prophylactic treatments.
Emel Aygören‐Pürsün, Regina Treudler, Petra Staubach, Inmaculada Martinez Saguer, Thomas Linhoff, Markus Magerl   +5 more
wiley   +1 more source

Editor's Choice Protein engineering strategies to develop lectins by design. [PDF]

Glycobiology
Hombu R, Beatty LE, Neelamegham S.
europepmc   +1 more source