Results 81 to 90 of about 43,176 (288)
Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair
Advanced Science, EarlyView.Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li +9 more
wiley +1 more source
Syk-coupled C-type lectins in immunity
Trends in Immunology, 2011 The Syk-coupled C-type lectin receptor Dectin-1 was the first non-Toll like receptor described that could mediate its own intracellular signalling. It was initially identified as important for the innate recognition of and response to fungal pathogens but later studies revealed that it is also involved in triggering adaptive immune responses.
Kerrigan, Ann M., Brown, Gordon D.
openaire +2 more sources
Signaling pathways for transduction of the initial message of the glycocode into cellular responses [PDF]
, 1998 The sugar units of glycan structures store information and establish an alphabet of life. The language of the oligosaccharide coding units is deciphered by receptors such as lectins and the decoded message can be transduced by multiple signaling pathways.
Gabius, Hans-Joachim +2 more
core +1 more source
Renal IGFBP6 Interacts With THBS1 to Drive Renal Cellular Senescence and Fibrosis
Advanced Science, EarlyView.ABSTRACT Epithelial dedifferentiation and myofibroblast activation are critical drivers of chronic kidney disease (CKD) progression. Elevated levels of IGFBP6 have been linked to decreased renal function in CKD patients, but its precise role and underlying mechanisms remain unclear.
Ju‐tao Yu +26 more
wiley +1 more source
Parasites & Vectors, 2014 Background The studies on sialomes have shown that hematophagous mosquito saliva consists of a lot of pharmacologically active proteins, in which C-type lectins have been identified and regarded as an important component of saliva.
Jinzhi Cheng +5 more
doaj +1 more source
From Snake Venom’s Disintegrins and C-Type Lectins to Anti-Platelet Drugs
Toxins, 2019 Snake venoms are attractive natural sources for drug discovery and development, with a number of substances either in clinical use or in research and development.
Philip Lazarovici +2 more
doaj +1 more source
Targeting C-Type Lectin Receptors for Cancer Immunity [PDF]
Frontiers in Immunology, 2015 C-type lectin receptors (CLRs) are a large family of soluble and trans-membrane pattern recognition receptors that are widely and primarily expressed on myeloid cells. CLRs are important for cell-cell communication and host defense against pathogens through the recognition of specific carbohydrate structures. Similar to a family of Toll-like receptors,
Huimin eYan +6 more
openaire +3 more sources
Domain and phylogenetic analysis of 105 C-type lectins identified in M.separata, using DoMosaics.
, 2022 Domain and phylogenetic analysis of 105 C-type lectins identified in M.separata, using DoMosaics. CTL_tree_domain.jpg is the CTL tree developed using DoMosaics. C_type_lectin_ID.txt shows the ID of C-type lectin genes in M.
Kakeru Yokoi (5627273)
core +1 more source
Advanced Science, EarlyView.Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao +19 more
wiley +1 more source
Identification of CLEC10A as a human lectin for pancreatic ductal adenocarcinoma
Scientific ReportsThe mechanism by which glycans in pancreatic ductal adenocarcinoma (PDAC) interact with human endogenous lectins in the tumor microenvironment remains largely unknown.
Shuntaro Tsukamoto +9 more
doaj +1 more source