Results 41 to 50 of about 3,299 (264)

In view of an express regulation: Considering the scope and soundness of a contrario reasoning

Informal Logic, 2008
A contrario reasoning (or ‘a contrario argument’ or ‘argument a contrario’) is traditionally understood as an appeal to the deliberate silence of the legislator: because a legal rule does not mention case X specifically, the rule is not applicable to it.
Henrike Jansen
doaj   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Machine learning and legal argument [PDF]

, 2021
Although the argumentation justifying decisions in particular cases has always been central to AI and Law, it has recently become a burning issue as black box machine learning approaches become prevalent. In this paper we review the understanding of legal argument that has been developed in AI and Law, and indicate the most appropriate ways in which ...
Jack Mumford, Katie Atkinson, Trevor J. M. Bench-Capon   +2 more
openaire   +1 more source

Legal Argumentation and the Nature of Law

SSRN Electronic Journal, 2023
This chapter focuses on whether any of four carefully selected contemporary theories of law—Michael Moore's theory, Joseph Raz's theory, Robert Alexy's theory, and Alf Ross's theory—have interesting implications for legal argumentation. I argue (1) that Moore's and Alexy's theories of law have interesting implications for the interpretation and ...
openaire   +2 more sources

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

Preface: Methodologies for Research on Legal Argumentation

Informal Logic, 2016
Preface
Michał Araszkiewicz, Thomasz Zurek
doaj   +3 more sources

INTERDISCIPLINARY SYSTEMIC JURIDICAL ARGUMENTATION: A NEW WAY TO JUSTIFY EMPHATICALLY AND EFFECTIVELLY

Revista Eletrônica de Direito Processual, 2018
The article discusses the interdisciplinary systemic juridical argumentation. We propose to elevate the legal argumentation to a complete and integral level.
Jorge Isaac Torres Manrique
doaj   +1 more source

Wavelength‐Dependent Photobiomodulation Regulates Macrophage Polarization via Mitochondrial Dynamics and Metabolic Reprogramming

Advanced Science, EarlyView.
Light wavelength encodes distinct macrophage fates through mitochondrial and metabolic remodeling. Red 625 nm irradiation induces glycolysis, mitochondrial fission, and M1 polarization, whereas near‐infrared 850 nm irradiation promotes fatty acid oxidation, mitochondrial fusion, and M2 polarization.
Qiusheng Shi, Hao Jia, Jianfei Dong, Linhao Li, Jingqi Cao, Xun Chen, Zhenzhen Jia, Jing Na, Zhijie Yang, Xinyuan Chen, Yubo Fan, Shuhua Yue, Lisha Zheng   +12 more
wiley   +1 more source

ZER1 Restrains Pressure Overload‐Induced Cardiac Remodeling by Targeting DVL2 for Gly/N‐Degron‐Dependent Degradation

Advanced Science, EarlyView.
Pressure overload suppresses cardiomyocyte ZER1, weakening CRL2Zer1‐mediated DVL2 degradation and allowing DVL2 accumulation. Elevated DVL2 activates CaMKII‐HDAC4‐MEF2C signaling, drives fetal gene reactivation, and promotes pathological remodeling.
Mingchao Jiang, Zhehao Lin, Lu Chen, Ying Ni, Jun Zhou, Wenjuan Zhang, Huilin Wang, Peifeng Ying, Xiu Lu, Kai Wang, Qingran Kong, Naxin Xu, Dingsheng Zhao, Jianwei Li, Guohui Zhong, Xingchen Meng, Sarkawt Hamad, Junmeng Zheng, Yuan Fu, Rongjiang Qin, Xuran Chu, Shangxuan Li, Youyou Li, Yili Wu, Yi Wang, Weihong Song, Yingxian Li, Shukuan Ling   +27 more
wiley   +1 more source

Proporcionalidade -- insuficiências morais e teóricas

Teoria Jurídica Contemporânea, 2017
RESUMO: O artigo pretende engajar-se de maneira crítica com a proporcionalidade enquanto meta-regra decisória. É dividido em três seções, além da introdução.
Daniel Peixoto Murata
doaj   +1 more source