Results 1 to 10 of about 129,759 (292)

Sand flies: Basic information on the vectors of leishmaniasis and their interactions with Leishmania parasites

Communications Biology, 2022
Blood-sucking arthropods transmit a variety of human pathogens acting as disseminators of the so-called vector-borne diseases. Leishmaniasis is a spectrum of diseases caused by different Leishmania species, transmitted quasi worldwide by sand flies ...
P. Cecílio, A. Cordeiro-da-Silva, Fabiano Oliveira   +2 more
semanticscholar   +1 more source

Laboratory diagnostics for human Leishmania infections: a polymerase chain reaction-focussed review of detection and identification methods

Parasites & Vectors, 2022
Leishmania infections span a range of clinical syndromes and impact humans from many geographic foci, but primarily the world’s poorest regions. Transmitted by the bite of a female sand fly, Leishmania infections are increasing with human movement (due ...
I. Gow, N. Smith, D. Stark, J. Ellis
semanticscholar   +1 more source

Antibiotic-Free Nanoplasmids as Promising Alternatives for Conventional DNA Vectors

Vaccines, 2022
DNA vaccines with their extraordinary properties are the best choice as vectors for subunit vaccines but are not in compliance with safety regulations, mainly because of the antibiotic resistance genes on their backbone.
Negar Seyed, Farnaz Zahedifard, Sima Habibzadeh, Roya Yousefi, Mahya Sadat Lajevardi, Elham Gholami, Sima Rafati   +6 more
doaj   +1 more source

Identification of asymptomatic Leishmania infections: a scoping review

Parasites & Vectors, 2022
Asymptomatic Leishmania infection may play an important role in the transmission of the parasite in endemic areas. At present there is no consensus on the definition of asymptomatic Leishmania infection, nor is there a safe and accessible gold standard ...
A. Ibarra-Meneses, Audrey Corbeil, V. Wagner, C. Onwuchekwa, Christopher Fernández-Prada   +4 more
semanticscholar   +1 more source

Leishmania tarentolae as Potential Live Vaccine Co-Expressing Distinct Salivary Gland Proteins Against Experimental Cutaneous Leishmaniasis in BALB/c Mice Model

Frontiers in Immunology, 2022
Leishmaniasis is a neglected vector-borne disease caused by Leishmania parasites transmitted through the infected sand flies bite. Current treatments are limited, partly due to their high cost and significant adverse effects, and no human vaccine is yet ...
Mahya Sadat Lajevardi, Mahya Sadat Lajevardi, Elham Gholami, Tahereh Taheri, Hamzeh Sarvnaz, Sima Habibzadeh, Negar Seyed, Yousef Mortazavi, Sima Rafati   +8 more
doaj   +1 more source

Structural analysis of PpSP15 and PsSP9 sand fly salivary proteins designed with a self-cleavable linker as a live vaccine candidate against cutaneous leishmaniasis

Parasites & Vectors, 2022
Background Leishmania parasites are deposited in the host through sand fly bites along with sand fly saliva. Therefore, salivary proteins are promising vaccine candidates for controlling leishmaniasis.
Mahya Sadat Lajevardi, Tahereh Taheri, Elham Gholami, Negar Seyed, Sima Rafati   +4 more
doaj   +1 more source

Promastigote-to-Amastigote Conversion in Leishmania spp.—A Molecular View

Pathogens, 2022
A key factor in the successful infection of a mammalian host by Leishmania parasites is their conversion from extracellular motile promastigotes into intracellular amastigotes. We discuss the physical and chemical triggers that induce this conversion and
Joachim Clos, Janne Grünebast, Myrine Holm   +2 more
doaj   +1 more source

Leishmania Protein Kinases: Important Regulators of the Parasite Life Cycle and Molecular Targets for Treating Leishmaniasis

Microorganisms, 2021
Leishmania is a protozoan parasite of the trypanosomatid family, causing a wide range of diseases with different clinical manifestations including cutaneous, mucocutaneous and visceral leishmaniasis.
A. Efstathiou, D. Smirlis
semanticscholar   +1 more source

Suicidal Leishmania [PDF]

Pathogens, 2020
Leishmania are obligate intracellular parasites known to have developed successful ways of efficient immunity evasion. Because of this, leishmaniasis, a disease caused by these flagellated protists, is ranked as one of the most serious tropical infections worldwide.
Lucie Podešvová, Tereza Leštinová, Eva Horáková, Julius Lukeš, Petr Volf, Vyacheslav Yurchenko   +5 more
openaire   +3 more sources

Systematic functional analysis of Leishmania protein kinases identifies regulators of differentiation or survival

Nature Communications, 2020
Differentiation between distinct stages is fundamental for the life cycle of intracellular protozoan parasites and for transmission between hosts, requiring stringent spatial and temporal regulation.
Baker N., Catta-Preta C.M.C., Neish R., Sadlova J., Powell B., Alves-Ferreira E.V.C., Geoghegan V., Carnielli J.B.T., Newling K., Hughes C., Vojtkova B., A. J, Mihut A., Walrad P.B., Wilson L.G., Pitchford J.W., V. P., Mottram J.C.   +17 more
semanticscholar   +1 more source