Results 1 to 10 of about 155,594 (285)

Profiling Serine Hydrolases in the Leishmania Host-Pathogen Interactome Using Cell-Permeable Activity-Based Fluorophosphonate Probes. [PDF]

Chembiochem
Leishmaniasis poses a global health challenge with limited treatment options and rising drug resistance. Activity‐based protein profiling using fluorophosphonate probes is employed to profile serine hydrolases, key virulence factors in Leishmania mexicana.
Isern JA, Porta EOJ, Kalesh K, Koutsogiannis Z, Cazzola D, Pohl E, Denny PW, Steel PG.   +7 more
europepmc   +2 more sources

Co-endemicity of schistosomiasis and tegumentary leishmaniasis: Spatial co-clustering in endemic areas. [PDF]

Trop Med Int Health
Abstract Objectives Schistosomiasis and tegumentary leishmaniasis simultaneously affect areas in tropical and subtropical regions. Co‐infected individuals show a less‐than‐optimal response to treatment and increased regulatory immune responses. However, no study has determined where Schistosoma–Leishmania co‐infections are more likely to occur ...
Camelo GMA, Silva JKAO, Gomes DS, Maggi L, Geiger SM, Barbosa DS, Negrão-Corrêa DA.   +6 more
europepmc   +2 more sources

Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background [PDF]

, 2012
The evolution of drug-resistance in pathogens is a major global health threat. Elucidating the molecular basis of pathogen drug-resistance has been the focus of many studies but rarely is it known whether a drug-resistance mechanism identified is ...
A Debrabant, A Dube, A Mehta, A Mukherjee, AB Sidhu, AC Coelho, AH Fairlamb, Ashutosh, B Gourbal, B Vergnes, Basudha Khanal, BJ Mookerjee, C Brochu, C Dumas, CS Ferreira, D Legare, DM Weinreich, F Chappuis, F Frezard, G Mandal, Graham H. Coombs, H Denton, H Shim, Hideo Imamura, HW Murray, J Alvar, J Hellemans, J Mikus, J Tovar, JC Mottram, JC Munday, Jean-Claude Dujardin, JM Kelly, K Ait-Oudhia, K Grondin, KC Carter, Kirstyn Brunker, KW Tintaya, L Flohe, M Maharjan, M Samant, M Vanaerschot, Manu Vanaerschot, MK Mittal, ML Cunningham, MR Ariyanayagam, MR Perry, N Beerenwinkel, N Singh, N Van Meirvenne, P Baiocco, PJ Alcolea, PR Romao, R Hadighi, R Lira, R Mukhopadhyay, R Rojas, R Singh, RA Williams, RI da Luz, RL Krauth-Siegel, RL Krauth-Siegel, S Borrell, S Decuypere, S Dey, S Gagneux, S Mandal, S Muller, S Rais, S Rijal, S Sundar, S Wyllie, S Wyllie, S Yan, S Yan, Saskia Decuypere, Suman Rijal, Sylke Müller, T Downing, T Downing, T Laurent, T Nozaki, Timothy G. Geary, V Adaui, V Yardley, Y Zhou   +85 more
core   +28 more sources

Leishmania tarentolae as Potential Live Vaccine Co-Expressing Distinct Salivary Gland Proteins Against Experimental Cutaneous Leishmaniasis in BALB/c Mice Model

Frontiers in Immunology, 2022
Leishmaniasis is a neglected vector-borne disease caused by Leishmania parasites transmitted through the infected sand flies bite. Current treatments are limited, partly due to their high cost and significant adverse effects, and no human vaccine is yet ...
Mahya Sadat Lajevardi, Mahya Sadat Lajevardi, Elham Gholami, Tahereh Taheri, Hamzeh Sarvnaz, Sima Habibzadeh, Negar Seyed, Yousef Mortazavi, Sima Rafati   +8 more
doaj   +1 more source

Antibiotic-Free Nanoplasmids as Promising Alternatives for Conventional DNA Vectors

Vaccines, 2022
DNA vaccines with their extraordinary properties are the best choice as vectors for subunit vaccines but are not in compliance with safety regulations, mainly because of the antibiotic resistance genes on their backbone.
Negar Seyed, Farnaz Zahedifard, Sima Habibzadeh, Roya Yousefi, Mahya Sadat Lajevardi, Elham Gholami, Sima Rafati   +6 more
doaj   +1 more source

Structural analysis of PpSP15 and PsSP9 sand fly salivary proteins designed with a self-cleavable linker as a live vaccine candidate against cutaneous leishmaniasis

Parasites & Vectors, 2022
Background Leishmania parasites are deposited in the host through sand fly bites along with sand fly saliva. Therefore, salivary proteins are promising vaccine candidates for controlling leishmaniasis.
Mahya Sadat Lajevardi, Tahereh Taheri, Elham Gholami, Negar Seyed, Sima Rafati   +4 more
doaj   +1 more source

Promastigote-to-Amastigote Conversion in Leishmania spp.—A Molecular View

Pathogens, 2022
A key factor in the successful infection of a mammalian host by Leishmania parasites is their conversion from extracellular motile promastigotes into intracellular amastigotes. We discuss the physical and chemical triggers that induce this conversion and
Joachim Clos, Janne Grünebast, Myrine Holm   +2 more
doaj   +1 more source

The first detection of Leishmania major in naturally infected Sergentomyia minuta in Portugal [PDF]

, 2013
Phlebotomine sandflies of the genus Sergentomyia are widely distributed throughout the Old World. It has been suggested that Sergentomyia spp are involved in the transmission of Leishmania in India and Africa, whereas Phlebotomus spp are thought to be ...
Afonso, Maria Odete, Campino, Lenea, Cortes, Sofia, Dionisio, Lidia, Maia, Carla, Neto, Luis   +5 more
core   +7 more sources

Suicidal Leishmania [PDF]

Pathogens, 2020
Leishmania are obligate intracellular parasites known to have developed successful ways of efficient immunity evasion. Because of this, leishmaniasis, a disease caused by these flagellated protists, is ranked as one of the most serious tropical infections worldwide.
Lucie Podešvová, Tereza Leštinová, Eva Horáková, Julius Lukeš, Petr Volf, Vyacheslav Yurchenko   +5 more
openaire   +3 more sources

Cultivation of Protozoa Parasites In Vitro: Growth Potential in Conventional Culture Media versus RPMI-PY Medium

Veterinary Sciences, 2023
The in vitro cultivation of Leishmania and Trypanosoma parasites plays an important role in the diagnosis and treatment of parasitic diseases. Although Evans’s modified Tobie and Novy–MacNeal–Nicolle media, for Leishmania spp.
Germano Castelli, Eugenia Oliveri, Viviana Valenza, Susanna Giardina, Flavia Facciponte, Francesco La Russa, Fabrizio Vitale, Federica Bruno   +7 more
doaj   +1 more source