Results 11 to 20 of about 56,189 (179)

Inhibitory effect of O-propargyllawsone in A549 lung adenocarcinoma cells

BMC Complementary Medicine and Therapies, 2023
Background Lung cancer is the deadliest type of cancer in the world and the search for compounds that can treat this disease is highly important. Lawsone (2-hydroxy-1,4-naphtoquinone) is a naphthoquinone found in plants from the Lawsone genus that show a
Edmilson Willian Propheta dos Santos, Rauan Cruz de Sousa, Mariana Nobre Farias de Franca, Jileno Ferreira Santos, Flaviano Melo Ottoni, Raquel Geralda Isidório, Waldecy de Lucca Junior, Ricardo José Alves, Ricardo Scher, Cristiane Bani Corrêa   +9 more
doaj   +1 more source

Experimental treatment with sodium stibogluconate of hamsters infected with Leishmania (Leishmania) chagasi and Leishmania (Leishmania) amazonensis [PDF]

Revista da Sociedade Brasileira de Medicina Tropical, 1999
The present paper reports the experimental treatment of hamsters infected with Leishmania chagasi and Leishmania amazonensis with sodium stibogluconate (20mg/kg/day x 20 days). Only with L. chagasi did the treatment result in the complete elimination of parasites from the spleen. However, no parasitological cure was achieved in hamsters infected with L.
Figueiredo, Elizabeth M. de, Silva, Jaime Costa e, Brazil, Reginaldo P.   +2 more
openaire   +4 more sources

Real-time PCR to differentiate among Leishmania (Viannia) subgenus, Leishmania (Leishmania) infantum and Leishmania (Leishmania) amazonensis: Application on Brazilian clinical samples

Acta Tropica, 2020
Leishmaniasis is a complex disease caused by Leishmania species belonging to subgenera Leishmania and Viannia. In South America, L. (L.) infantum is considered the most important causative agent of visceral leishmaniasis, while L. (L.) amazonensis and Viannia subgenus species are responsible for the different cutaneous or mucocutaneous forms.
Diotallevi, Aurora, Buffi, Gloria, Ceccarelli, Marcello, Neitzke-Abreu, Herintha Coeto, Gnutzmann, Laisa Vieira, da Costa Lima, Manoel Sebastião, Di Domenico, Alice, De Santi, Mauro, Magnani, Mauro, Galluzzi, Luca   +9 more
openaire   +3 more sources

Complex ecological interactions across a focus of cutaneous leishmaniasis in Eastern Colombia: novel description of Leishmania species, hosts and phlebotomine fauna [PDF]

Royal Society Open Science, 2020
This study aimed to analyse the patterns of diversity, blood sources and Leishmania species of phlebotomines in a focus of cutaneous leishmaniasis in Arboledas, Eastern Colombia.
Claudia M. Sandoval-Ramírez, Carolina Hernández, Aníbal A. Teherán, Reinaldo Gutierrez-Marin, Ruth A. Martínez-Vega, Duvan Morales, Richard Hoyos-Lopez, Astrid Araque-Mogollón, Juan David Ramírez   +8 more
doaj   +1 more source

Leishmania (Leishmania) amazonenisInfection, Suriname

Emerging Infectious Diseases, 2008
To the Editor: A 17-year-old man was seen at the Dermatology Service in Paramaribo (Suriname) with a skin condition that he had had since he was 5 years of age. The condition consisted of multiple cutaneous ulcerations, nodules, and fibrotic plaques disseminated on his face, limbs, and trunk, and subcutaneous nodules on lymph-draining tracts on his ...
van der Meide, W., de Vries, H.J.C., Pratlong, F., van der Wal, A.C., Sabajo, L.   +4 more
openaire   +4 more sources

Trends in malaria indicators after scale-up of community-based malaria management in Afghanistan

Malaria Journal, 2022
Background The Community-Based Malaria Management (CBMM) strategy, introduced in 2013 and expanded to all health facilities and health posts in Afghanistan by 2016, aimed to deliver rapid diagnostic testing and more timely treatment to all communities ...
Sayed Daoud Mahmoodi, Abdul Alim Atarud, Ahmad Walid Sediqi, Sarah Gallalee, Willi McFarland, Temesgen Birara Aynie, Mohmmad Sami Nahzat, Hamida Hamid, Ghulam Qader Qader, Mohammad Shoaib Tamim, Ali Mirzazadeh   +10 more
doaj   +1 more source

Phlebotomine sand flies (Diptera: Psychodidae) associated with changing patterns in the transmission of the human cutaneous leishmaniasis in French Guiana

Memorias do Instituto Oswaldo Cruz, 2007
Between March 2000 and December 2001 a survey of the sand flies (Diptera: Phlebotominae) of French Guiana was carried out during 14 nights of captures with CDC light-traps and Malaise traps, and resulted in the collection of 2245 individuals of 38 ...
Florence Fouque, Pascal Gaborit, Jean Issaly, Romuald Carinci, Jean-Charles Gantier, Christophe Ravel, Jean-Pierre Dedet   +6 more
doaj   +1 more source

Sphingolipid Degradation in Leishmania (Leishmania) amazonensis

PLoS Neglected Tropical Diseases, 2012
Human leishmaniasis is caused by more than 20 Leishmania species and has a wide range of symptoms. Our recent studies have demonstrated the essential role of sphingolipid degradation in the virulence of Leishmania (Leishmania) major, a species responsible for localized cutaneous leishmaniasis in the Old World.
Agiesh Balakrishna Pillai, Wei Xu, Ou Zhang, Kai Zhang   +3 more
openaire   +4 more sources

Visualization of Leishmania tropica Infection in BALB/c Mice by Bioluminescence Imaging

Iranian Biomedical Journal, 2020
Background: Leishmania tropica is the cause of more than one form of leishmaniasis and lacks a known reservoir animal. This study compares the potential infectivity of recombinant and wild-type L. tropica in BALB/c mice.
Mahdieh Eskandar, Elham Gholami, Negar Seyed, Yasaman Taslimi, Sima Habibzadeh, Sima Rafati, Tahereh Taheri   +6 more
doaj  

Leishmania kinetoplast DNA contributes to parasite burden in infected macrophages: Critical role of the cGAS-STING-TBK1 signaling pathway in macrophage parasitemia

Frontiers in Immunology, 2022
Leishmania parasites harbor a unique network of circular DNA known as kinetoplast DNA (kDNA). The role of kDNA in leishmania infections is poorly understood. Herein, we show that kDNA delivery to the cytosol of Leishmania major infected THP-1 macrophages
Ismail Cem Yilmaz, Ismail Cem Yilmaz, Emre Dunuroglu, Ihsan Cihan Ayanoglu, Emre Mert Ipekoglu, Muzaffer Yildirim, Nogay Girginkardesler, Yusuf Ozbel, Seray Toz, Ahmet Ozbilgin, Gamze Aykut, Ihsan Gursel, Ihsan Gursel, Mayda Gursel, Mayda Gursel   +14 more
doaj   +1 more source