Results 11 to 20 of about 129,759 (292)

A second generation leishmanization vaccine with a markerless attenuated Leishmania major strain using CRISPR gene editing

Nature Communications, 2020
Leishmaniasis is a neglected tropical disease caused by Leishmania protozoa transmitted by infected sand flies. Vaccination through leishmanization with live Leishmania major has been used successfully but is no longer practiced because it resulted in ...
Wen Wei Zhang, S. Karmakar, Sreenivas Gannavaram, R. Dey, Patrick Lypaczewski, Nevien Ismail, A. Siddiqui, V. Simonyan, Fabiano Oliveira, Iliano V. Coutinho-Abreu, Thiago DeSouza-Vieira, C. Meneses, James Oristian, T. D. Serafim, Abu Musa, R. Nakamura, N. Saljoughian, Greta Volpedo, Monika Satoskar, Monika Satoskar, S. Satoskar, S. Satoskar, Pradeep K. Dagur, J. McCoy, S. Kamhawi, J. Valenzuela, S. Hamano, A. Satoskar, G. Matlashewski, H. Nakhasi   +29 more
semanticscholar   +1 more source

Cultivation of Protozoa Parasites In Vitro: Growth Potential in Conventional Culture Media versus RPMI-PY Medium

Veterinary Sciences, 2023
The in vitro cultivation of Leishmania and Trypanosoma parasites plays an important role in the diagnosis and treatment of parasitic diseases. Although Evans’s modified Tobie and Novy–MacNeal–Nicolle media, for Leishmania spp.
Germano Castelli, Eugenia Oliveri, Viviana Valenza, Susanna Giardina, Flavia Facciponte, Francesco La Russa, Fabrizio Vitale, Federica Bruno   +7 more
doaj   +1 more source

An interactive database of Leishmania species distribution in the Americas

Scientific Data, 2020
The Americas have an elevated number of leishmaniasis cases (accounting for two-thirds of the worldwide disease burden) and circulating Leishmania species, and are therefore of interest in terms of epidemiological surveillance.
Giovanny Herrera, Natalia Barragán, Nicolás Luna, David Martínez, Frasella De Martino, J. Medina, Sergio Niño, Luisa Páez, Angie L Ramírez, Laura Vega, Valeria Velandia, Michelle Vera, María Fernanda Zúñiga, Marius Bottin, J. Ramírez   +14 more
semanticscholar   +1 more source

Molecular Diagnosis of Leishmaniasis: Quantification of Parasite Load by a Real-Time PCR Assay with High Sensitivity

Pathogens, 2021
Real-time PCR was developed to quantify Leishmania infantum kinetoplast DNA and optimized to achieve a sensitivity of 1 parasite/mL. For this purpose, we cloned the conserved kDNA fragment of 120 bp into competent cells and correlated them with serial ...
Germano Castelli, Federica Bruno, Stefano Reale, Simone Catanzaro, Viviana Valenza, Fabrizio Vitale   +5 more
doaj   +1 more source

Comparison of Protective Potency of DNA and Live Vaccines Expressing A2-CPA-CPB-CTE Antigens against Visceral Leish-maniasis in Syrian Hamster as Preliminary Study

Iranian Journal of Parasitology, 2020
Background: Visceral leishmaniasis is the most severe form of leishmaniasis caused by Leishmania (L.) donovani complex. Drug-resistant strains have been developed as a consequence of the current chemotherapeutic interventions, which has increased the ...
Yasaman TASLIMI, Farnaz ZAHEDIFARD, Tahereh TAHERI, Delaram DOROUD, Sakineh LATIF DIZAJI, Noushin SALJOUGHIAN, Sima RAFATI   +6 more
doaj   +1 more source

Isolation, characterization, and functional study of extracellular vesicles derived from Leishmania tarentolae

Frontiers in Cellular and Infection Microbiology, 2022
Leishmania (L.) species are protozoan parasites with a complex life cycle consisting of a number of developmental forms that alternate between the sand fly vector and their host. The non-pathogenic species L.
Mehrdad Shokouhy, Mehrdad Shokouhy, Hamzeh Sarvnaz, Yasaman Taslimi, Mahya Sadat Lajevardi, Sima Habibzadeh, Amir Mizbani, Faezeh Shekari, Mandana Behbahani, Ana Claudia Torrecilhas, Sima Rafati   +10 more
doaj   +1 more source

A Historical Overview of the Classification, Evolution, and Dispersion of Leishmania Parasites and Sandflies

PLoS Neglected Tropical Diseases, 2016
Background The aim of this study is to describe the major evolutionary historical events among Leishmania, sandflies, and the associated animal reservoirs in detail, in accordance with the geographical evolution of the Earth, which has not been ...
M. Akhoundi, K. Kuhls, A. Cannet, J. Votýpka, P. Marty, P. Delaunay, D. Sereno   +6 more
semanticscholar   +1 more source

Anti-proliferative and pro-apoptotic activity of glycosidic derivatives of lawsone in melanoma cancer cell

BMC Cancer, 2021
Background Melanoma is a malignant cancer that affects melanocytes and is considered the most aggressive skin-type cancer. The prevalence for melanoma cancer for the last five year is about one million cases.
Mariana Nobre Farias de Franca, Raquel Geralda Isidório, João Henrique Oliveira Bonifacio, Edmilson Willian Propheta dos Santos, Jileno Ferreira Santos, Flaviano Melo Ottoni, Waldecy de Lucca Junior, Ricardo Scher, Ricardo José Alves, Cristiane Bani Corrêa   +9 more
doaj   +1 more source

Inhibitory effect of O-propargyllawsone in A549 lung adenocarcinoma cells

BMC Complementary Medicine and Therapies, 2023
Background Lung cancer is the deadliest type of cancer in the world and the search for compounds that can treat this disease is highly important. Lawsone (2-hydroxy-1,4-naphtoquinone) is a naphthoquinone found in plants from the Lawsone genus that show a
Edmilson Willian Propheta dos Santos, Rauan Cruz de Sousa, Mariana Nobre Farias de Franca, Jileno Ferreira Santos, Flaviano Melo Ottoni, Raquel Geralda Isidório, Waldecy de Lucca Junior, Ricardo José Alves, Ricardo Scher, Cristiane Bani Corrêa   +9 more
doaj   +1 more source

Experimental treatment with sodium stibogluconate of hamsters infected with Leishmania (Leishmania) chagasi and Leishmania (Leishmania) amazonensis [PDF]

Revista da Sociedade Brasileira de Medicina Tropical, 1999
The present paper reports the experimental treatment of hamsters infected with Leishmania chagasi and Leishmania amazonensis with sodium stibogluconate (20mg/kg/day x 20 days). Only with L. chagasi did the treatment result in the complete elimination of parasites from the spleen. However, no parasitological cure was achieved in hamsters infected with L.
Figueiredo, Elizabeth M. de, Silva, Jaime Costa e, Brazil, Reginaldo P.   +2 more
openaire   +4 more sources