Results 31 to 40 of about 158,467 (267)

The Leishmania major BBSome subunit BBS1 is essential for parasite virulence in the mammalian host [PDF]

, 2013
Bardet–Biedl syndrome (BBS) is a human genetic disorder with a spectrum of symptoms caused by primary cilium dysfunction. The disease is caused by mutations in one of at least 17 identified genes, of which seven encode subunits of the BBSome, a protein ...
Doehl, Johannes, Farrant, Katie, Hodgkinson, Michael R., Paape, Daniel, Price, Helen P., Smith, Deborah F., Stark, Meg   +6 more
core   +1 more source

Enhanced Glycolysis Is Required for Antileishmanial Functions of Neutrophils Upon Infection With Leishmania donovani

Frontiers in Immunology, 2021
Visceral leishmaniasis (VL) is a fatal parasitic disease if untreated. Treatment options of VL diminish due to emerging drug resistance. Although the principal host cells for the multiplication of Leishmania are macrophages, neutrophils are the first ...
Mareike Ohms, Carolina Ferreira, Carolina Ferreira, Hauke Busch, Inken Wohlers, Ana Cristina Guerra de Souza, Ricardo Silvestre, Ricardo Silvestre, Tamás Laskay   +8 more
doaj   +1 more source

Complex ecological interactions across a focus of cutaneous leishmaniasis in Eastern Colombia: novel description of Leishmania species, hosts and phlebotomine fauna [PDF]

Royal Society Open Science, 2020
This study aimed to analyse the patterns of diversity, blood sources and Leishmania species of phlebotomines in a focus of cutaneous leishmaniasis in Arboledas, Eastern Colombia.
Claudia M. Sandoval-Ramírez, Carolina Hernández, Aníbal A. Teherán, Reinaldo Gutierrez-Marin, Ruth A. Martínez-Vega, Duvan Morales, Richard Hoyos-Lopez, Astrid Araque-Mogollón, Juan David Ramírez   +8 more
doaj   +1 more source

Analysis by RNA-seq of transcriptomic changes elicited by heat shock in Leishmania major [PDF]

, 2019
Besides their medical relevance, Leishmania is an adequate model for studying post-transcriptional mechanisms of gene expression. In this microorganism, mRNA degradation/stabilization mechanisms together with translational control and post-translational ...
Aguado, Begoña, Corvo, Laura, Lombraña, Rodrigo, Rastrojo, Alberto, Requena, Jose M., Solana, Jose C.   +5 more
core   +2 more sources

Cell migration induced by Leishmania (Leishmania) amazonensis, Leishmania (Leishmania) major and Leishmania (Viannia) braziliensis into the peritoneal cavity of BALB/c mice [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2010
In American cutaneous leishmaniasis, the initial infection phase is characterized by recruitment of neutrophils and monocytes. The migration of these cells in response to the presence of Leishmania in the peritoneum of affected animals remains unclear. The objective of this study was to investigate cell migration to the peritoneum of BALB/c mice after ...
Wakimoto, DT, Gaspareto, KV, Silveira, TGV, Lonardoni, MVC, Aristides, SMA   +4 more
openaire   +5 more sources

Visualization of Leishmania tropica Infection in BALB/c Mice by Bioluminescence Imaging

Iranian Biomedical Journal, 2020
Background: Leishmania tropica is the cause of more than one form of leishmaniasis and lacks a known reservoir animal. This study compares the potential infectivity of recombinant and wild-type L. tropica in BALB/c mice.
Mahdieh Eskandar, Elham Gholami, Negar Seyed, Yasaman Taslimi, Sima Habibzadeh, Sima Rafati, Tahereh Taheri   +6 more
doaj  

Distinct roles in autophagy and importance in infectivity of the two ATG4 cysteine peptidases of leishmania major [PDF]

, 2012
Macroautophagy in Leishmania, which is important for the cellular remodeling required during differentiation, relies upon the hydrolytic activity of two ATG4 cysteine peptidases (ATG4.1 and ATG4.2).
Afonso, Azad, Besteiro, Betin, Betin, Bhattacharya, Boya, Cabrera, Dalle-Donne, Deretic, Dolai, Dolai, Garami, Geng, Goldman, Graef, Graham H. Coombs, Hosokawa, Jeremy C. Mottram, Kim, Kimura, Kimura, Kirisako, Kirisako, Krebiehl, Köchl, Lee, Lemasters, Li, Manjithaya, Mariño, Mariño, Mariño, Medina-Acosta, Misslitz, Mortensen, Mottram, Mörck, Mörck, Nair, Okamoto, Read, Roderick A.M. Williams, Sacks, Schapira, Scherz-Shouval, Scherz-Shouval, Scherz-Shouval, Scherz-Shouval, Tanida, Tanida, Williams, Williams, Williams, Williams, Wong, Xie, Yoshimoto, Youle   +58 more
core   +1 more source

Optimized Mouse BMDC Isolation and Culture under Endotoxin-Free Conditions

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2021
Introduction: Dendritic cells are very important in basic studies and vaccine research, but isolation and culture of these cells face challenges due to their small number in tissues.
Atefeh Sadeghi Shermeh, Sima HAbibzadeh, Adeleh Taghikhani, Sima Rafati, Negar Seyed   +4 more
doaj  

Leishmania (Leishmania) amazonenisInfection, Suriname

Emerging Infectious Diseases, 2008
To the Editor: A 17-year-old man was seen at the Dermatology Service in Paramaribo (Suriname) with a skin condition that he had had since he was 5 years of age. The condition consisted of multiple cutaneous ulcerations, nodules, and fibrotic plaques disseminated on his face, limbs, and trunk, and subcutaneous nodules on lymph-draining tracts on his ...
van der Meide, W., de Vries, H.J.C., Pratlong, F., van der Wal, A.C., Sabajo, L.   +4 more
openaire   +4 more sources

Gene expression in Leishmania is regulated predominantly by gene dosage [PDF]

, 2017
Leishmania tropica, a unicellular eukaryotic parasite present in North and East Africa, the Middle East, and the Indian subcontinent, has been linked to large outbreaks of cutaneous leishmaniasis in displaced populations in Iraq, Jordan, and Syria. Here,
Berriman, Matthew, Beverley, Stephen M., Cotton, James A., Durrant, Caroline, Grigg, Michael E., Iantorno, Stefano A., Khan, Asis, Myler, Peter, Ouellette, Marc, Sacks, David L., Sanders, Mandy J., Warren, Wesley C., Weiss, Louis M.   +12 more
core   +3 more sources