Results 31 to 40 of about 204,538 (326)

Leishmania kinetoplast DNA contributes to parasite burden in infected macrophages: Critical role of the cGAS-STING-TBK1 signaling pathway in macrophage parasitemia

Frontiers in Immunology, 2022
Leishmania parasites harbor a unique network of circular DNA known as kinetoplast DNA (kDNA). The role of kDNA in leishmania infections is poorly understood. Herein, we show that kDNA delivery to the cytosol of Leishmania major infected THP-1 macrophages
Ismail Cem Yilmaz, Ismail Cem Yilmaz, Emre Dunuroglu, Ihsan Cihan Ayanoglu, Emre Mert Ipekoglu, Muzaffer Yildirim, Nogay Girginkardesler, Yusuf Ozbel, Seray Toz, Ahmet Ozbilgin, Gamze Aykut, Ihsan Gursel, Ihsan Gursel, Mayda Gursel, Mayda Gursel   +14 more
doaj   +1 more source

Functional compartmentalization of Rad9 and Hus1 reveals diverse assembly of the 9-1-1 complex components during the DNA damage response in Leishmania [PDF]

, 2016
The Rad9-Rad1-Hus1 (9-1-1) complex is a key component in the coordination of DNA damage sensing, cell cycle progression and DNA repair pathways in eukaryotic cells. This PCNA-related trimer is loaded onto RPA-coated single stranded DNA and interacts with
Damasceno, Jeziel D., McCulloch, Richard, Obonaga, Ricardo, Santos, Elaine V., Scott, Alan, Tosi, Luiz R.O.   +5 more
core   +1 more source

Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition

Nature Communications, 2019
Leishmania RNA virus (LRV) is an important virulence factor associated with the development of mucocutaneous Leishmaniasis, a severe form of the disease.
R. V. D. de Carvalho, Djalma S. Lima-Junior, Marcus Vinícius G. da Silva, Marisa Dilucca, T. Rodrigues, Catarina V. Horta, Alexandre L. N. Silva, Patrick F. da Silva, F. Frantz, L. Lorenzon, Marcos Michel Souza, Fausto Almeida, L. M. Cantanhêde, R. G. M. Ferreira, A. Cruz, D. Zamboni   +15 more
semanticscholar   +1 more source

Sphingolipid Degradation in Leishmania (Leishmania) amazonensis

PLoS Neglected Tropical Diseases, 2012
Human leishmaniasis is caused by more than 20 Leishmania species and has a wide range of symptoms. Our recent studies have demonstrated the essential role of sphingolipid degradation in the virulence of Leishmania (Leishmania) major, a species responsible for localized cutaneous leishmaniasis in the Old World.
Wei Xu, Kai Zhang, Ou Zhang, Agiesh Balakrishna Pillai   +3 more
openaire   +5 more sources

Insights on adaptive and innate immunity in canine leishmaniosis [PDF]

, 2016
Canine leishmaniosis (CanL) is caused by the parasite Leishmania infantum and is a systemic disease, which can present with variable clinical signs, and clinicopathological abnormalities.
Abi Abdallah, Alexander, Catchpole, DAMER P. BLAKE, de Souza Carmo, Green, Kensil, LAIA SOLANO-GALLEGO, Lopez, Margarito, Ordeix, Pinelli, Pitta, Quinnell, Sadick, Sanchez, SHAZIA HOSEIN, Silva, Vouldoukis, Wakelin   +19 more
core   +3 more sources

Detection of Leishmania DNA in wild foxes and associated ticks in Patagonia, Argentina, 2000 km south of its known distribution area [PDF]

, 2016
Indexación: Web of Science; PubMedBackground: Zoonotic Visceral Leishmaniasis (ZVL) is a vector-borne disease affecting humans and other mammals and caused by the protozoan parasite Leishmania (Leishmania) infantum (syn. L.
Ferroglio, Ezio, López-Bao, José Vicente, Millán, Javier, Rodríguez, Alejandro, Travaini, Alejandro, Trisciuoglio, Anna, Zanet, Stefania   +6 more
core   +4 more sources

Genetic dissection of a Leishmania flagellar proteome demonstrates requirement for directional motility in sand fly infections

bioRxiv, 2018
The protozoan parasite Leishmania possesses a single flagellum, which is remodelled during the parasite’s life cycle from a long motile flagellum in promastigote forms in the sand fly to a short immotile flagellum in amastigotes residing in mammalian ...
T. Beneke, F. Demay, E. Hookway, Nicole Ashman, Heather Jeffery, James Smith, Jessica Valli, Tomáš Bečvář, J. Myšková, T. Lestinova, Shahaan Shafiq, J. Sádlová, P. Volf, R. Wheeler, E. Gluenz   +14 more
semanticscholar   +1 more source

Detection of Leishmania RNA Virus in Leishmania Parasites

PLoS Neglected Tropical Diseases, 2013
Patients suffering from cutaneous leishmaniasis (CL) caused by New World Leishmania (Viannia) species are at high risk of developing mucosal (ML) or disseminated cutaneous leishmaniasis (DCL). After the formation of a primary skin lesion at the site of the bite by a Leishmania-infected sand fly, the infection can disseminate to form secondary lesions ...
Zangger, Haroun, Ronet, Catherine, Desponds, Chantal, Kuhlmann, F. Matthew, Robinson, John, Hartley, Mary-Anne, Prevel, Florence, Castiglioni, Patrik, Pratlong, Francine, Bastien, Patrick, Müller, Norbert, Parmentier, Laurent, Saravia, Nancy Gore, Beverley, Stephen, Fasel, Nicolas   +14 more
openaire   +11 more sources

Phlebotomine sand flies (Diptera: Psychodidae) associated with changing patterns in the transmission of the human cutaneous leishmaniasis in French Guiana

Memorias do Instituto Oswaldo Cruz, 2007
Between March 2000 and December 2001 a survey of the sand flies (Diptera: Phlebotominae) of French Guiana was carried out during 14 nights of captures with CDC light-traps and Malaise traps, and resulted in the collection of 2245 individuals of 38 ...
Florence Fouque, Pascal Gaborit, Jean Issaly, Romuald Carinci, Jean-Charles Gantier, Christophe Ravel, Jean-Pierre Dedet   +6 more
doaj   +1 more source

Changes to cholesterol trafficking in macrophages by Leishmania parasites infection [PDF]

, 2017
Leishmania spp. are protozoan parasites that are transmitted by sandfly vectors during blood sucking to vertebrate hosts and cause a spectrum of diseases called leishmaniases.
Anderson, Andrade-Neto, Antoine, Bansal, Berman, Blanchette-Mackie, Burack, Carstea, Carvalho, Chakraborty, Chattopadhyay, Collins, Coombs, Coppens, De Cicco, Desvergne, Duclos, Edwards, Ehrenman, Fernandes, Ghosh, Ghosh, Ghosh, Ginger, Ginger, Goldstein, Groener, Hamid, Hart, Ikonen, Infante, Johndrow, Kima, Kima, Kok, Kwon, Lal, Lecoeur, Lippuner, Livak, Majumder, Maxfield, McIntosh, Misslitz, Naureckiene, Neufeld, Osorio y Fortea, Ovalle-Bracho, Paape, Paape, Pereira, Portugal, Pucadyil, Rabhi, Redgrave, Roberts, Rosenzweig, Rub, Russell, Saunders, Sen, Shamshiev, Soares, Sorensen, Tetley, Tewary, Tontonoz, Weinheber   +67 more
core   +2 more sources