Results 51 to 60 of about 158,924 (268)

RNA synthesis in Leishmania donovani is constitutive during stage conversion: a genome-wide PRO-seq analysis

Microbiology Spectrum
Transcription in Leishmania donovani has long been considered constitutive, as shown by nuclear run-on analyses and northern blots, with gene expression primarily regulated post-transcriptionally.
Janne Grünebast, Stephan Lorenzen, Christine Brinker, Annika Bea, Joachim Clos   +4 more
doaj   +1 more source

Influence of Testosterone in Neglected Tropical Diseases: Clinical Aspects in Leprosy and In Vitro Experiments in Leishmaniasis

Tropical Medicine and Infectious Disease, 2023
Neglected tropical diseases encompass a group of chronic and debilitating infectious diseases that primarily affect marginalized populations. Among these diseases, leprosy and leishmaniasis are endemic in numerous countries and can result in severe and ...
Laís Lima de Oliveira Rekowsky, Daniela Teles de Oliveira, Rodrigo Anselmo Cazzaniga, Lucas Sousa Magalhães, Lenise Franco Albuquerque, Jonnia Maria Sherlock Araujo, Martha Débora Lira Tenório, Tiziane Cotta Machado, Michael W. Lipscomb, Priscila Lima dos Santos, Amelia Ribeiro de Jesus, Márcio Bezerra-Santos, Ricardo Luís Louzada da Silva   +12 more
doaj   +1 more source

In Vitro Screening Test Using Leishmania Promastigotes Stably Expressing mCherry Protein [PDF]

, 2014
Transgenic Leishmania major and Leishmania donovani axenic promastigotes constitutively expressing mCherry were used for in vitro antileishmanial drug screening. This method requires minimal sample manipulation and can be easily adapted to automatic drug
Miguel A. Morales, Vacchina, Paola
core   +2 more sources

Housekeeping by Leishmania

Trends in Parasitology, 2006
The observation that differentiation of parasite life cycle stages involves structural and functional reorganisation is very familiar. A recent paper by Besteiro and colleagues provides an intriguing insight into cellular remodelling during differentiation.
openaire   +3 more sources

Exploring Bioactive Metabolites From Fusarium falciforme and Aspergillus terreus Isolated From Protease‐Rich Fruits: Antifungal, Antitrypanosomal, and Enzymatic Inhibitory Activities

Chemistry &Biodiversity, EarlyView.
Metabolites from fungi isolated from protease rich‐fruits displayed antifungal, antitrypanosomal and enzymatic inhibitory activities. ABSTRACT Fungal secondary metabolites display remarkable chemical diversity and biological potential, with applications in agriculture and pharmaceuticals. This study isolated and characterized bioactive metabolites from
Gabriela de Oliveira Almeida, Vitor de Souza Mazucato, Ludmilla Tonani, Marcia Regina von Zeska Kress, Gisele Barbosa, Renata Krogh, Adriano Defini Andricopulo, Leonardo Luiz Gomes Ferreira, Paulo Cezar Vieira   +8 more
wiley   +1 more source

Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection. [PDF]

, 1994
Leishmania major are intramacrophage parasites whose eradication requires the induction of T helper 1 (Th1) effector cells capable of activating macrophages to a microbicidal state.
Locksley, RM, Reiner, SL, Stowring, L, Wang, ZE, Zheng, S   +4 more
core   +1 more source

Genome Mining Reveals a Novel Nephthenol‐Producing Diterpene Synthase from the Sandfly Lutzomyia Longipalpis

ChemBioChem, EarlyView.
The discovery of a terpene synthase of insect origin that makes the apparently cryptic product nephthenol from geranylgeranyl diphosphate sheds light on hidden biosynthetic potential. Populations of the sandfly, Lutzomyia longipalpis, use the diterpene sobralene as a sex/aggregation pheromone, which is likely produced in the insect through the activity
Charles Ducker, Catherine McKeown, Igor F. P. Da Silva, Isis Torres Souza, John A. Pickett, Antônio E. G. Santana, Neil J. Oldham   +6 more
wiley   +1 more source

Manifestaciones tóxicas cardiovasculares con el uso de antimoniales en una paciente con leishmaniasis cutánea

Medicina U.P.B., 2019
La toxicidad por antimoniales tiene múltiples manifestaciones sistémicas, entre ellas, las alteraciones cardiovasculares son de las de mayor gravedad, que pueden, incluso, llevar a la muerte.
Adrián Valverde Legarda
doaj   +1 more source

Eugenol-Rich Essential Oil from Pimenta dioica: In Vitro and In Vivo Potentialities against Leishmania amazonensis

Pharmaceuticals, 2023
Pimenta dioica L. is one the most recognized species with diverse biological activities. In this study, in vitro activity and in vivo efficacy of essential oil from P. dioica (EO-Pd) was evaluated.
Lianet Monzote, Laura Machín, Adiel González, Ramón Scull, Yamilet I. Gutiérrez, Prabodh Satyal, Lars Gille, William N. Setzer   +7 more
doaj   +1 more source

Infectiousness in a Cohort of Brazilian Dogs: Why Culling Fails to Control Visceral Leishmaniasis in Areas of High Transmission [PDF]

, 2002
The elimination of seropositive dogs in Brazil has been used to control zoonotic visceral leishmaniasis but with little success. To elucidate the reasons for this, the infectiousness of 50 sentinel dogs exposed to natural Leishmania chagasi infection was
Courtenay, O., Dye, C., Garcez, L.M., Quinnell, R.J., Shaw, J.J.   +4 more
core