Results 51 to 60 of about 129,759 (292)

Arginine and Polyamines Fate in Leishmania Infection

Frontiers in Microbiology, 2018
Leishmania is a protozoan parasite that alternates its life cycle between the sand fly and the mammalian host macrophages, involving several environmental changes.
S. Muxel, J. I. Aoki, J. C. R. Fernandes, M. F. Laranjeira-Silva, R. Zampieri, S. M. Acuña, K. E. Müller, R. Vanderlinde, L. Floeter-Winter   +8 more
semanticscholar   +1 more source

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

RNA synthesis in Leishmania donovani is constitutive during stage conversion: a genome-wide PRO-seq analysis

Microbiology Spectrum
Transcription in Leishmania donovani has long been considered constitutive, as shown by nuclear run-on analyses and northern blots, with gene expression primarily regulated post-transcriptionally.
Janne Grünebast, Stephan Lorenzen, Christine Brinker, Annika Bea, Joachim Clos   +4 more
doaj   +1 more source

The Gut Microbiome of the Vector Lutzomyia longipalpis Is Essential for Survival of Leishmania infantum

mBio, 2017
The vector-borne disease leishmaniasis, caused by Leishmania species protozoa, is transmitted to humans by phlebotomine sand flies. Development of Leishmania to infective metacyclic promastigotes in the insect gut, a process termed metacyclogenesis, is ...
Patrick H. Kelly, S. Bahr, T. D. Serafim, N. Ajami, J. Petrosino, C. Meneses, J. Kirby, J. Valenzuela, S. Kamhawi, M. Wilson   +9 more
semanticscholar   +1 more source

Chemical and Biological Properties of Hymenaea courbaril L.: A Review

Chemistry &Biodiversity, EarlyView.
PRISMA‐style flowchart showing the screening process of studies identified and selected in the review has been added to the attachments. ABSTRACT Hymenaea courbaril L., commonly known as jatobá, is a plant traditionally used by native populations for medicinal purposes, in addition to providing edible fruits and durable wood for construction.
Cicera Alane Coelho Gonçalves, Geane Gabriele de Oliveira Souza, Ana Maria Fernandes Duarte, Joice Barbosa do Nascimento, Fázia Fernandes Galvão Rodrigues, José Galberto Martins da Costa, Fabíola Fernandes Galvão Rodrigues   +6 more
wiley   +1 more source

Sequential blood meals augment vector infectiousness by promoting Leishmania replication and triggering amplification of metacyclics via a novel retroleptomonad developmental stage

Nature Microbiology, 2018
Sand flies, similar to most vectors, take multiple blood meals during their lifetime1–4. The effect of subsequent blood meals on pathogens developing in the vector and their impact on disease transmission have never been examined.
T. D. Serafim, Iliano V. Coutinho-Abreu, Fabiano Oliveira, C. Meneses, S. Kamhawi, J. Valenzuela   +5 more
semanticscholar   +1 more source

Synthesis and Evaluation of the First Generation of Glycosylated Nucleoside Analogues as Potential Inhibitors of the Base J Metabolism in Kinetoplastid Parasites

Chemistry – A European Journal, EarlyView.
Novel analogues of the kinetoplastid‐specific DNA base J unlock a new way to target parasite epigenetic regulation. Some compounds selectively inhibit Leishmania and Trypanosoma species without harming human cells, revealing a promising route toward innovative antiparasitic therapies.
Océane Monfret, Dan Liu, Manon Louis, Sihem Rebei, Dominique Urban, Yann Bourdreux, Elisabeth Mouray, Philippe Grellier, Gilles Doisneau, Dominique Guianvarc'h   +9 more
wiley   +1 more source

Morphogenesis Dynamics in Leishmania Differentiation

Pathogens, 2022
Leishmania, the causative agent of leishmaniasis, is an obligatory intracellular parasite that cycles between phagolysosome of mammalian macrophages, where it resides as round intracellular amastigotes, and the midgut of female sandflies, where it ...
Ramu Dandugudumula, Renana Fischer-Weinberger, Dan Zilberstein   +2 more
doaj   +1 more source

Harnessing controlled human infection models to accelerate vaccine development for neglected tropical diseases: Lessons from leishmaniasis. [PDF]

Eur J Clin Invest
Controlled Human Infection Models (CHIMs) offer a powerful approach to accelerate vaccine development for neglected tropical diseases (NTDs). This review highlights scientific and translational advances enabled by CHIMs, with a focus on a novel Leishmania major model.
Parkash V.
europepmc   +2 more sources

Monodentate Phosphine Modulation in Cyclometallated Platinum(II) Complexes for Antileishmanial, Antiviral, and Antitumor Applications

ChemMedChem, EarlyView.
Schematic representation depicting the influence of phosphine ligand identity on the biological and physicochemical characteristics of Pt(II) complexes: PTA promotes antileishmanial activity, PPh2(Php–COOH) strengthens antiviral activity, and TCEP enhances fluorescence.
Antonio A. de Oliveira‐Neto, Gustavo Clauss, Jennyfer Castro, Marcus S. A. Garcia, Natasha M. Cassani, Bruna C. Sandim, Ana Laura C. Oliveira, Stephanie P. B. Reyes, Nádija N. P. da Silva, Fillipe V. Rocha, Ana C. G. Jardim, Danilo C. Miguel, Camilla Abbehausen   +12 more
wiley   +1 more source