Results 61 to 70 of about 169,942 (293)

Functional compartmentalization of Rad9 and Hus1 reveals diverse assembly of the 9-1-1 complex components during the DNA damage response in Leishmania [PDF]

, 2016
The Rad9-Rad1-Hus1 (9-1-1) complex is a key component in the coordination of DNA damage sensing, cell cycle progression and DNA repair pathways in eukaryotic cells. This PCNA-related trimer is loaded onto RPA-coated single stranded DNA and interacts with
Damasceno, Jeziel D., McCulloch, Richard, Obonaga, Ricardo, Santos, Elaine V., Scott, Alan, Tosi, Luiz R.O.   +5 more
core   +1 more source

Detection of Leishmania RNA Virus in Leishmania Parasites

PLoS Neglected Tropical Diseases, 2013
Patients suffering from cutaneous leishmaniasis (CL) caused by New World Leishmania (Viannia) species are at high risk of developing mucosal (ML) or disseminated cutaneous leishmaniasis (DCL). After the formation of a primary skin lesion at the site of the bite by a Leishmania-infected sand fly, the infection can disseminate to form secondary lesions ...
Zangger, Haroun, Ronet, Catherine, Desponds, Chantal, Kuhlmann, F. Matthew, Robinson, John, Hartley, Mary-Anne, Prevel, Florence, Castiglioni, Patrik, Pratlong, Francine, Bastien, Patrick, Müller, Norbert, Parmentier, Laurent, Saravia, Nancy Gore, Beverley, Stephen, Fasel, Nicolas   +14 more
openaire   +10 more sources

Artificial intelligence strategies for predicting kinase inhibitor resistance: A comprehensive review of methods, challenges, and future perspectives

Journal of Intelligent Medicine, EarlyView.
Abstract Kinase inhibitors are essential in targeted cancer therapy, yet resistance often emerges through secondary mutations, activation of compensatory signaling pathways, or drug‐efflux mechanisms. Artificial intelligence (AI) provides a workflow‐based strategy rather than a list of unrelated tools for predicting and addressing kinase‐inhibitor ...
Faris Hassan, Mohanad Ali Deifallah, Alaa Zaghloul, Rania Elgohary   +3 more
wiley   +1 more source

PUF Proteins as Critical RNA-Binding Proteins in TriTryp Parasites: A Review Article

Iranian Journal of Parasitology
In eukaryotes, translation is a fundamental step in the long pathway of protein synthesis within the cell. In this process, several proteins and factors have involved directly or indirectly, individually or in association with other elements to contact ...
Tahereh Taheri, Elaheh Davarpanah, Katayon Samimi-Rad, Negar Seyed   +3 more
doaj   +1 more source

Systems analysis of host-parasite interactions. [PDF]

, 2015
Parasitic diseases caused by protozoan pathogens lead to hundreds of thousands of deaths per year in addition to substantial suffering and socioeconomic decline for millions of people worldwide.
Jamshidi, Neema, Lewis, Nathan E, Swann, Justine, Winzeler, Elizabeth A   +3 more
core   +1 more source

Relationships Between European Wildcats and Domestic Cats in an Area of Sympatry: Exploring Key Conservation Questions on Hybridization and Disease Transmission

Animal Conservation, EarlyView.
We have found evidence of behavioural barriers for both hybridization and disease transmission between European wildcats and domestic cats. This includes hierarchical interspecies exclusion enforced by wildcats, as well as sexual selection exerted by wildcat females.
Jose María Gil‐Sánchez, Elena Bertos, Mariola Sánchez‐Cerdá, Emilio Virgós, Marcos Moleón   +4 more
wiley   +1 more source

Detection and identification of Leishmania species within naturally infected sand flies in the Andean areas of Ecuador by a polymerase chain reaction [PDF]

, 2005
The surveillance of prevalent Leishmania and sand fly species in endemic areas is important for prediction of the risk and expansion of leishmaniasis. In this study, we developed a polymerase chain reaction (PCR)-based method for detection of Leishmania ...
Barroso, Paola Andrea, Calvopina, Manuel, Gomez, Eduardo, Hashiguchi, Yoshihisa, Iwata, Hiroyuki, Katakura, Ken, Kato, Hirotomo, Korenaga, Masataka, Marco, Jorge Diego, Mimori, Tatsuyuki, Nonaka, Shigeo, Uezato, Hiroshi   +11 more
core   +1 more source

The Astonishing Large Family of HSP40/DnaJ Proteins Existing in Leishmania [PDF]

, 2022
José Carlos Solana, Lorena Bernardo, Javier Moreno, Begoña Aguado, José M. Requena   +4 more
openalex   +1 more source

Harnessing controlled human infection models to accelerate vaccine development for neglected tropical diseases: Lessons from leishmaniasis

European Journal of Clinical Investigation, EarlyView.
Controlled Human Infection Models (CHIMs) offer a powerful approach to accelerate vaccine development for neglected tropical diseases (NTDs). This review highlights scientific and translational advances enabled by CHIMs, with a focus on a novel Leishmania major model.
Vivak Parkash
wiley   +1 more source

Production of Recombinant Leishmania Tropica Parasites Expressing Two Proteins of Egfp and Luciferase Reporter

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2017
BACKGROUND AND OBJECTIVE: L. tropica is the major cause of cutaneous and visceral leishmaniasis in Iran. Due to lack of an accurate, sensitive and noninvasive detection test in animal model is a major problem. Here, we designed L.
T Taheri, M Eskandar, S Rafati
doaj