Results 61 to 70 of about 129,759 (292)

Resolution and pro-resolving lipid mediators in Leishmania infection

Journal of Medical Microbiology and Infectious Diseases, 2019
The acute inflammatory response is the body’s natural reaction to inciting stimuli including trauma and pathogens. Well-known pro-inflammatory metabolites take control of this reaction to recruit the leukocytes into the inflamed tissue.
Negar Seyed, Sima Rafati
doaj  

Regulation of immunity during visceral Leishmania infection

Parasites & Vectors, 2016
Unicellular eukaryotes of the genus Leishmania are collectively responsible for a heterogeneous group of diseases known as leishmaniasis. The visceral form of leishmaniasis, caused by L. donovani or L.
V. Rodrigues, A. Cordeiro-da-Silva, Mireille Laforge, Ricardo Silvestre, J. Estaquier   +4 more
semanticscholar   +1 more source

A two‐sample Mendelian randomization study and mediation analysis exploring the link between cathepsins and epilepsy

Epilepsia Open, EarlyView.
Abstract Objective This study aims to investigate the causal relationship between cathepsins and epilepsy, using Mendelian randomization (MR) and mediation analysis. Methods Publicly accessible summary statistics on epilepsy were obtained from FinnGen and the International League Against Epilepsy Consortium.
Huaiyu Sun, Di Ma, Wuqiong Zhang, Shuai Hou, Zhiqing Chen, Xuewei Li, Hongmei Meng, Daguang Zhang   +7 more
wiley   +1 more source

Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Amplification

mBio, 2018
Protozoan parasites of the genus Leishmania cause severe human and veterinary diseases worldwide, termed leishmaniases. A hallmark of Leishmania biology is its capacity to adapt to a variety of unpredictable fluctuations inside its human host, notably ...
G. Bussotti, Evi Gouzelou, Mariana Côrtes Boité, Ihcen Kherachi, Z. Harrat, Naouel Eddaikra, J. Mottram, M. Antoniou, Vasiliki Christodoulou, Aymen Bali, F. Guerfali, D. Laouini, M. Mukhtar, F. Dumetz, J. Dujardin, D. Smirlis, P. Lechat, P. Pescher, Adil El Hamouchi, M. Lemrani, C. Chicharro, I. P. Llanes-Acevedo, L. Botana, I. Cruz, J. Moreno, F. Jeddi, K. Aoun, A. Bouratbine, E. Cupolillo, G. Späth   +29 more
semanticscholar   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

PUF Proteins as Critical RNA-Binding Proteins in TriTryp Parasites: A Review Article

Iranian Journal of Parasitology
In eukaryotes, translation is a fundamental step in the long pathway of protein synthesis within the cell. In this process, several proteins and factors have involved directly or indirectly, individually or in association with other elements to contact ...
Tahereh Taheri, Elaheh Davarpanah, Katayon Samimi-Rad, Negar Seyed   +3 more
doaj   +1 more source

Leishmania, microbiota and sand fly immunity

Parasitology, 2018
In this review, we explore the state-of-the-art of sand fly relationships with microbiota, viruses and Leishmania, with particular emphasis on the vector immune responses. Insect-borne diseases are a major public health problem in the world. Phlebotomine
E. Telleria, Andrea Martins-da-Silva, A. Tempone, Y. Traub-Csekö   +3 more
semanticscholar   +1 more source

Artificial intelligence strategies for predicting kinase inhibitor resistance: A comprehensive review of methods, challenges, and future perspectives

Journal of Intelligent Medicine, EarlyView.
Abstract Kinase inhibitors are essential in targeted cancer therapy, yet resistance often emerges through secondary mutations, activation of compensatory signaling pathways, or drug‐efflux mechanisms. Artificial intelligence (AI) provides a workflow‐based strategy rather than a list of unrelated tools for predicting and addressing kinase‐inhibitor ...
Faris Hassan, Mohanad Ali Deifallah, Alaa Zaghloul, Rania Elgohary   +3 more
wiley   +1 more source

Leishmania Hijacks Myeloid Cells for Immune Escape

Frontiers in Microbiology, 2018
Protozoan parasites of the Leishmania genus are the causative agents of leishmaniasis, a group of neglected tropical diseases whose clinical manifestations vary depending on the infectious Leishmania species but also on host factors.
María Martínez-López, M. Soto, S. Iborra, D. Sancho   +3 more
semanticscholar   +1 more source

Relationships Between European Wildcats and Domestic Cats in an Area of Sympatry: Exploring Key Conservation Questions on Hybridization and Disease Transmission

Animal Conservation, EarlyView.
We have found evidence of behavioural barriers for both hybridization and disease transmission between European wildcats and domestic cats. This includes hierarchical interspecies exclusion enforced by wildcats, as well as sexual selection exerted by wildcat females.
Jose María Gil‐Sánchez, Elena Bertos, Mariola Sánchez‐Cerdá, Emilio Virgós, Marcos Moleón   +4 more
wiley   +1 more source