Results 81 to 90 of about 129,759 (292)

The structural, functional, and therapeutic potential of metacaspases in fungi and protozoa

The FEBS Journal, EarlyView.
Metacaspases are Ca2+‐dependent cysteine proteases whose structural characteristics, particularly calcium binding and autocatalytic processing, govern their activation and biological functions. These enzymes differ among microorganisms and regulate their cell cycles, making them excellent targets for drug development.
Ane C. M. Duarte, Mariana N. R. Trujilho, Karolaine S. S. M. Valdivia, Aline F. Araujo, Laura M. C. de Lorena, Vinicius H. de Oliveira, Beatriz V. Pereira, Emilly R. Leme, Wagner A. S. Júdice, Maurício F. M. Machado   +9 more
wiley   +1 more source

Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin

Nature Communications, 2017
Leishmania is a single-celled eukaryotic parasite afflicting millions of humans worldwide, with current therapies limited to a poor selection of drugs that mostly target elements in the parasite’s cell envelope.
M. Shalev-Benami, Yan Zhang, H. Rozenberg, Yuko Nobe, M. Taoka, D. Matzov, E. Zimmerman, A. Bashan, T. Isobe, C. Jaffe, A. Yonath, G. Skiniotis   +11 more
semanticscholar   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Altered miRNA expression in the lesions of cutaneous leishmaniasis caused by L. major and L. tropica with insights into apoptosis regulation

Scientific Reports
Leishmaniasis is a vector-borne infectious disease that affects many subtropical countries. Leishmania (L.) major and L. tropica are among the old-world causative agents and cause cutaneous leishmaniasis (CL).
Taha Masoudsinaki, Shima Hadifar, Hamzeh Sarvnaz, Mohammad Farahmand, Nasrin Masoudzadeh, Vahid Mashayekhi Goyonlo, Mohammadali Kerachian, Reza Erfanian Salim, Mourad Barhoumi, Seyed Latif Mousavi Gargari, Hossein Heydari, Sima Rafati   +11 more
doaj   +1 more source

The circadian clock in immune cells controls the magnitude of Leishmania parasite infection

Scientific Reports, 2017
The intracellular parasite Leishmania uses neutrophils and macrophages as host cells upon infection. These immune cells harbour their own intrinsic circadian clocks, known to influence many aspects of their functions.
Silke Kiessling, Geneviève Dubeau-Laramée, Hyejee Ohm, N. Labrecque, M. Olivier, N. Cermakian   +5 more
semanticscholar   +1 more source

Artificial intelligence‐powered microscopy: Transforming the landscape of parasitology

Journal of Microscopy, EarlyView.
Abstract Microscopy and image analysis play a vital role in parasitology research; they are critical for identifying parasitic organisms and elucidating their complex life cycles. Despite major advancements in imaging and analysis, several challenges remain. These include the integration of interdisciplinary data; information derived from various model
Mariana De Niz, Sara Silva Pereira, David Kirchenbuechler, Leandro Lemgruber, Constadina Arvanitis   +4 more
wiley   +1 more source

Ultrastructural expansion microscopy reveals unexpected levels of glycosome heterogeneity in African trypanosomes

Journal of Microscopy, EarlyView.
Abstract Kinetoplastid parasites include several species. Trypanosoma brucei causes African sleeping sickness in humans and a wasting disease nagana in livestock. Trypanosoma cruzi is the causative agent of Chagas disease and Leishmania species cause leishmaniasis, which can present with visceral, cutaneous, or mucocutaneous symptoms.
Heidi Anderson, Rhonda Reigers Powell, Meredith Teilhet Morris   +2 more
wiley   +1 more source

Electrophoretic patterns of proteinuria in dogs with Cushing’s syndrome

Journal of Small Animal Practice, EarlyView.
Objectives To describe the electrophoretic pattern of proteinuria in dogs with naturally occurring Cushing’s syndrome. We hypothesised that urine protein electrophoresis in dogs with spontaneous Cushing’s syndrome will reveal glomerular proteinuria. We also hypothesised that the severity of proteinuria would decrease during treatment with trilostane ...
J. Milenkovic, T. Francey, A. Schweighauser, J. Howard, S. Kittl, M. Campos   +5 more
wiley   +1 more source

Innate Immunity Plays a Key Role in Leishmania Infection: Implications for Vaccine Design

Journal of Medical Microbiology and Infectious Diseases, 2016
Neutrophils are part of the first line of immune response and are essential for resistance against a variety of pathogens. They professionally mediate direct killing of pathogens, recruit other phagocytes by specific chemokines, produce cytokines and ...
Negar Seyed, Sima Rafati
doaj  

Intralesional gene expression profile of JAK-STAT signaling pathway and associated cytokines in Leishmania tropica-infected patients

Frontiers in Immunology
BackgroundThe JAK-STAT signaling pathway is a central cascade of signal transduction for the myriad of cytokines in which dysregulation has been implicated in progression of inflammatory and infectious diseases.
Shima Hadifar, Nasrin Masoudzadeh, Hossein Heydari, Vahid Mashayekhi Goyonlo, Mohammadali Kerachian, Maryam Daneshpazhooh, Ali Sadeghnia, Nasim Tootoonchi, Reza Erfanian Salim, Sima Rafati, Ali M. Harandi   +10 more
doaj   +1 more source