Results 101 to 110 of about 16,640 (230)

The leishmanicidal flavonols quercetin and quercitrin target Leishmania (Leishmania) amazonensis arginase

Experimental Parasitology, 2012
Polyamine biosynthesis enzymes are promising drug targets for the treatment of leishmaniasis, Chagas' disease and African sleeping sickness. Arginase, which is a metallohydrolase, is the first enzyme involved in polyamine biosynthesis and converts arginine into ornithine and urea.
da Silva, Edson Roberto, Maquiaveli, Claudia do Carmo, Magalhães, Prislaine Pupolin   +2 more
openaire   +2 more sources

Experimental treatment with sodium stibogluconate of hamsters infected with Leishmania (Leishmania) chagasi and Leishmania (Leishmania) amazonensis

Revista da Sociedade Brasileira de Medicina Tropical, 1999
The present paper reports the experimental treatment of hamsters infected with Leishmania chagasi and Leishmania amazonensis with sodium stibogluconate (20mg/kg/day x 20 days). Only with L.
Elizabeth M. de Figueiredo, Jaime Costa e Silva, Reginaldo P. Brazil   +2 more
doaj  

Leishmania amazonensis promastigotes present two distinct modes of nucleus and kinetoplast segregation during cell cycle. [PDF]

, 2015
: Here, we show the morphological events associated with organelle segregation and their timing in the cell cycle of a reference strain of Leishmania (L.) amazonensis promastigotes, the main causative agent of Tegumentary leishmaniasis in the Americas ...
Cano, Maria Isabel Nogueira, da Silva, Marcelo Santos, Elias, Maria Carolina, Freitas-Júnior, Lúcio de Holanda, Monteiro, Jomar Patrício, Nunes, Vinícius Santana, Perez, Arina Marina, Vasconcelos, Elton José   +7 more
core   +2 more sources

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva   +4 more
wiley   +1 more source

Modulation of fibroblast behavior by Leishmania: a pathway to understanding disease progression in cutaneous leishmaniasis

BMC Microbiology
Leishmaniasis is a parasitic infection caused by obligatory intracellular protozoa of the Leishmania genus. Macrophages are the main cell for Leishmania parasites that play a key role in immune response against it.
Tarcisio Navegante de Queiroz Filho, Brenda Furtado Costa, Ana Paula Drummond Rodrigues   +2 more
doaj   +1 more source

Autophagic Induction Greatly Enhances Leishmania major Intracellular Survival Compared to Leishmania amazonensis in CBA/j-Infected Macrophages

Frontiers in Microbiology, 2018
CBA mouse macrophages control Leishmania major infection yet are permissive to Leishmania amazonensis. Few studies have been conducted to assess the role played by autophagy in Leishmania infection.
Beatriz R. S. Dias, Carina S. de Souza, Niara de Jesus Almeida, José G. B. Lima, Kiyoshi F. Fukutani, Thiale B. S. dos Santos, Jaqueline França-Cost, Jaqueline França-Cost, Claudia I. Brodskyn, Juliana P. B. de Menezes, Maria I. Colombo, Patricia S. T. Veras   +11 more
doaj   +1 more source

The Genome Sequence of Leishmania (Leishmania) amazonensis: Functional Annotation and Extended Analysis of Gene Models [PDF]

, 2013
We present the sequencing and annotation of the Leishmania (Leishmania) amazonensis genome, an etiological agent of human cutaneous leishmaniasis in the Amazon region of Brazil. L.
Alpuche-Aranda, Arruda, Asato, Azizi, Bastien, Bateman, Bates, Britto, C. L. Barbieri, Camara Coelho, Castillo-Ramirez, Chen, Chen, Clayton, Comeron, D. Bahia, de Souza Carmo, De Souza Leao, Dedet, Edgar, Emanuelsson, F. Real, Fraga, G. A. G. Pereira, G. G. L. Costa, Gentil, Haas, Haile, Hkima Abou Fakher, Holmgren, Hutson, Ivens, J. F. da Silveira, J. M. C. Mondego, Kanehisa, Koski, Krauth-Siegel, L. M. de Carvalho, Lezama-Davila, Linares, Lomsadze, Lye, M. F. Carazzolle, M. R. d. S. Briones, M. Wurtele, Mannaert, Marchler-Bauer, Martinez-Calvillo, Mart  nez-Calvillo, Messing, Murray, Naderer, Ndjamen, Neubert, Ning, P. Mieczkowski, Paape, Paletta-Silva, Peacock, Pop, Quinn, R. A. Mortara, R. C. e Ferreira, R. H. Herai, R. O. Vidal, Rafati, Real, Real, Real, Rochette, Rochette, Ronquist, Rovai, Salotra, Scott, Sharp, Sharp, Silveira, Silverman, Slater, Smith, Sommer, Sterkers, Stober, Tuon, Whelan   +85 more
core   +2 more sources

Cell migration induced by Leishmania (Leishmania) amazonensis, Leishmania (Leishmania) major and Leishmania (Viannia) braziliensis into the peritoneal cavity of BALB/c mice

Journal of Venomous Animals and Toxins including Tropical Diseases, 2010
In American cutaneous leishmaniasis, the initial infection phase is characterized by recruitment of neutrophils and monocytes. The migration of these cells in response to the presence of Leishmania in the peritoneum of affected animals remains unclear ...
DT Wakimoto, KV Gaspareto, TGV Silveira, MVC Lonardoni, SMA Aristides   +4 more
doaj   +1 more source

Comparative two-dimensional gel electrophoresis maps for promastigotes of Leishmania amazonensis and Leishmania major

Brazilian Journal of Infectious Diseases
The outcome of Leishmania infections is determined by both the parasite species and the host genetic makeup. While much has been learned regarding immune responses to this parasite, our knowledge on parasite-derived factors is limited.
Reynolds K. B. Brobey, Fang C. Mei, Xiaodong Cheng, Lynn Soong   +3 more
doaj   +1 more source

Topical Simvastatin as Host-Directed Therapy against Severity of Cutaneous Leishmaniasis in Mice. [PDF]

, 2016
We recently demonstrated that statins mediate protection against intracellular pathogens, Mycobacterium tuberculosis and Listeria monocytogenes in mice.
Brombacher, F., Guler, R., Hartley, M.A., Hurdayal, R., Parihar, S.P.   +4 more
core   +1 more source