Results 181 to 190 of about 10,337 (219)
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Leishmania amazonensis: Acidic organelles in amastigotes
Experimental Parasitology, 1988Leishmania amastigotes are intracellular protozoan parasites which exclusively invade cells of the macrophage series and multiply within phagolysosomes. Recent studies showed that intracellular and isolated amastigotes of L. amazonesis are killed by amino acid esters which appear to be trapped within as yet unidentified, possibly acidified, "lysosome ...
J C, Antoine +3 more
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Veterinary Parasitology, 2010
Although bats are one of the most abundant mammals in the new world and are present in virtually all ecosystems, including urban and peri-urban environments, few studies have investigated the role of these animals in the epidemiological chain of leishmaniosis.
Elisa San Martin Mouriz, Savani +6 more
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Although bats are one of the most abundant mammals in the new world and are present in virtually all ecosystems, including urban and peri-urban environments, few studies have investigated the role of these animals in the epidemiological chain of leishmaniosis.
Elisa San Martin Mouriz, Savani +6 more
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Leishmania (Viannia) panamensis/Leishmania (Leishmania) amazonensis—A Warning
Parasitology Today, 1999The parasite Leishmania (Viannia) panamensis causes local cutaneous lesions. The Laboratory of Infectious Disease Pathology of the University of Sao Paulo Medical School has been working with a strain of Leishmania (Viannia) panamensis, HSJD-1, characterized by isoenzyme at the Liverpool School of Tropical Medicine, by W.
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Genomic organization of telomeric and subtelomeric sequences of Leishmania (Leishmania) amazonensis
International Journal for Parasitology, 2005Telomeres are DNA-protein complexes that protect linear chromosomes from degradation and fusions. Telomeric DNA is repetitive and G-rich, and protrudes towards the end of the chromosomes as 3'G-overhangs. In Leishmania spp., sequences adjacent to telomeres comprise the Leishmania conserved telomere associated sequences (LCTAS) that are around 100 bp ...
F F, Conte, M I N, Cano
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Veterinary Parasitology, 2008
The murine models of Leishmania infection are well-studied and suitable models for studying this disease, which, despite its incidence of nearly 2 million new cases worldwide per year and its prevalence of 12 million cases, has been a somewhat neglected disease.
Bernardo Acácio Santini, Pereira +1 more
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The murine models of Leishmania infection are well-studied and suitable models for studying this disease, which, despite its incidence of nearly 2 million new cases worldwide per year and its prevalence of 12 million cases, has been a somewhat neglected disease.
Bernardo Acácio Santini, Pereira +1 more
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Experimental Parasitology, 2004
Pathogenic protozoan proteases play crucial roles in the host-parasite interaction, and its characterization contributes to the understanding of protozoan disease mechanisms. A Leishmania amazonensis promastigote protease was purified 36-fold, using aprotinin-agarose affinity chromatography and gel filtration high performance liquid chromatography ...
Raquel Elisa, da Silva-Lopez +1 more
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Pathogenic protozoan proteases play crucial roles in the host-parasite interaction, and its characterization contributes to the understanding of protozoan disease mechanisms. A Leishmania amazonensis promastigote protease was purified 36-fold, using aprotinin-agarose affinity chromatography and gel filtration high performance liquid chromatography ...
Raquel Elisa, da Silva-Lopez +1 more
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Novel Selective Inhibitor of Leishmania (Leishmania) amazonensis Arginase
Chemical Biology & Drug Design, 2015Arginase is a glycosomal enzyme in Leishmania that is involved in polyamine and trypanothione biosynthesis. The central role of arginase in Leishmania (Leishmania) amazonensis was demonstrated by the generation of two mutants: one with an arginase lacking the glycosomal addressing signal and one in which the arginase‐coding gene was knocked out.
Edson R, da Silva +6 more
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Subcellular localization of an extracellular serine protease in Leishmania (Leishmania) amazonensis
Parasitology Research, 2004Extracellular proteolytic activity was detected in a Leishmania ( L.) amazonensis culture supernatant and a 56-kDa protein was purified using (NH4)2SO4 precipitation followed by affinity chromatography on aprotinin-agarose. A rabbit serum obtained against the 56-kDa extracellular serine protease was used in order to analyze its location in L.
R E, Silva-Lopez +4 more
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EFFECT OF HYPOXIA ON MACROPHAGE INFECTION BY LEISHMANIA AMAZONENSIS
Journal of Parasitology, 2004In the present study, we compared the effect of 5% oxygen tension (hypoxia) with a normal tension of 21% oxygen (normoxia) on macrophage infection by the protozoan parasite Leishmania amazonensis. Macrophages from different sources (human cell line U937, murine cell line J774, and murine peritoneal macrophages) exposed to hypoxia showed a reduction of ...
Marcelle Carolina, Colhone +3 more
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In vivo activity of perifosine against Leishmania amazonensis
Acta Tropica, 2008Miltefosine has been established as the first oral administration drug against cutaneous and visceral leishmaniasis. Other alkyl-phospholipids such as edelfosine have been tested against Leishmania showing an in vitro antiparasitic activity. Perifosine in vitro activity has been previously demonstrated against different Leishmania species including ...
M Gabriela, Cabrera-Serra +2 more
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